Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1982 • 3,566 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones

1998 • 448 citations

Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

1987 • 399 citations

Mutational specificity of depurination.

1984 • 361 citations

Insertion of nucleotides opposite apurinic apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides

1983 • 320 citations

The ‘A rule’ of mutagen specificity: A consequence of DNA polymerase bypass of non‐instructional lesions?

1991 • 260 citations

Cloning and Expression of Human G/T Mismatch-specific Thymine-DNA Glycosylase

1996 • 255 citations

Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases

1999 • 252 citations

ras and human tumors.

1992 • 224 citations

Suppression of spontaneous mutagenesis in human cells by DNA base excision–repair

2000 • 215 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7, 12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin

1993 • 199 citations

Ras Oncogene Mutations in Basal Cell Carcinomas and Squamous Cell Carcinomas of Human Skin

1990 • 178 citations

Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

1995 • 176 citations

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein

1999 • 166 citations

Translesional Synthesis on DNA Templates Containing a Single Abasic Site

1997 • 164 citations

Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule”

1997 • 163 citations

Substrate Binding by Human Apurinic/Apyrimidinic Endonuclease Indicates a Briggs-Haldane Mechanism

1997 • 154 citations

Base Pair Conformation-Dependent Excision of Benzo[a]Pyrene Diol Epoxide-Guanine Adducts by Human Nucleotide Excision Repair Enzymes

1997 • 149 citations

Mechanisms of ultraviolet-induced mutation

1987 • 130 citations

Repair of DNA lesions induced by polycyclic aromatic hydrocarbons in human cell-free extracts: involvement of two excision repair mechanisms in vitro

1998 • 118 citations

Recognition of DNA alterations by the mismatch repair system

1999 • 99 citations

Fidelity of Translesional Synthesis past Benzo[a]pyrene Diol Epoxide−2‘-Deoxyguanosine DNA Adducts: Marked Effects of Host Cell, Sequence Context, and Chirality

1996 • 90 citations

In vivo and in Vitro Replication Consequences of Stereoisomeric Benzo[a]pyrene-7,8-dihydrodiol 9,10-Epoxide Adducts on Adenine N6 at the Second Position of N-ras Codon 61

1995 • 89 citations

Translesional synthesis on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE (7, 8-dihydroxy-anti-9, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

1993 • 84 citations

7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo

1995 • 82 citations

Counteracting the mutagenic effect of hydrolytic deamination of DNA 5-methylcytosine residues at high temperature: DNA mismatch N-glycosylase Mig.Mth of the thermophilic archaeon Methanobacterium thermoautotrophicum THF.

1996 • 81 citations

System Issues: Mutagenic response of the endogenoushprt gene andlacl transgene in benzo[a]pyrene-treated Big Blue™ B6C3F1 mice

1996 • 77 citations

Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors

1997 • 77 citations

Relationship between excision repair and the cytotoxic and mutagenic effect of the ‘anti’ 7,8-diol-9,10-epoxide of benzo[a]pyrene in human cells

1982 • 72 citations

Characterization of the DNA polymerase requirement of human base excision repair

1996 • 69 citations

Cell cycle checkpoints and DNA repair preserve the stability of the human genome

1995 • 68 citations

Site-specific rates of excision repair of benzo[a]pyrene diol epoxide adducts in the hypoxanthine phosphoribosyltransferase gene of human fibroblasts: correlation with mutation spectra.

1995 • 66 citations

Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin

1987 • 65 citations

The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspective, prospects and problems

1996 • 65 citations

Mutagenesis by apurinic sites in normal and ataxia telangiectasia human lymphoblastoid cells

1992 • 64 citations

Benzoαaαpyrene-induced skin damage and tumor promotion in the mouse

1991 • 63 citations

CYCLIC CHANGES IN THE SKIN OF THE MOUSE¹

1953 • 62 citations

Synthesis and tumor-initiating activity in mouse skin of dibenzo[a,l]pyrene syn- and anti-fjord-region diolepoxides

1994 • 57 citations

DNA polymerase action on benzo[a]pyrene—DNA adducts

1992 • 57 citations

Metabolism and mutagenicity of dibenzo[a,e]pyrene and the very potent environmental carcinogen dibenzo[a,l]pyrene

1990 • 56 citations

Bypass and termination at apurinic sites during replication of single-stranded DNA in vitro: a model for apurinic site mutagenesis.

1988 • 55 citations

Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR–RFLP method

1998 • 51 citations

Mutational spectra in the lacl gene in skin from 7, 12‐dimethylbenz[a]anthracene‐treated and untreated transgenic mice

1995 • 51 citations

Macromolecular synthesis following a single application of polycyclic hydrocarbons used as initiators of mouse skin tumorigenesis.

1974 • 50 citations

Excision repair of UV- or benzo[a]pyrene diol epoxide-induced lesions in xeroderma pigmentosum variant cells is ‘error free’

1985 • 50 citations

Repair of abasic sites by mammalian cell extracts

1994 • 48 citations

In vitroreplication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo [a]pyrene-7, 8-dihydrodiol-9, 10-epoxide adducts

1995 • 42 citations

Birth and death/differentiation rates of papillomas in mouse skin

1992 • 42 citations

Abasic sites from cytosine as termination signals for DNA synthesis

1985 • 40 citations

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels

1993 • 40 citations

Recognition of DNA alterations by the mismatch repair system

1999 • 37 citations

Fidelity and Mutational Specificity of Uracil-initiated Base Excision DNA Repair Synthesis in Human Glioblastoma Cell Extracts

1998 • 34 citations

Structure, Conformations, and Repair of DNA Adducts from Dibenzo[a,l]pyrene: ³²P-Postlabeling and Fluorescence Studies

1998 • 34 citations

The binding of 7,12-dimethylbenz(a)anthracene to replicating and non-replicating DNA in mouse skin

1974 • 30 citations

Benzo[alpha]pyrene diol epoxide I binds to DNA at replication forks.

1988 • 30 citations

Replication Error Rates for G·dGTP, T·dGTP, and A·dGTP Mispairs and Evidence for Differential Proofreading by Leading and Lagging Strand DNA Replication Complexes in Human Cells

1995 • 28 citations

Escherichia coli exonuclease III enhances long PCR amplification of damaged DNA templates

2000 • 27 citations

Evidence that initiated keratinocytes clonally expand into multiple existing hair follicles during papilloma histogenesis in SENCAR mouse skin

1997 • 26 citations

On the mechanism of preferential incorporation of dAMP at abasic sites in translesional DNA synthesis. Role of proof reading activity of DNA polymerase and thermodynamic characterization of model template-primers containing an abasic site

1995 • 23 citations

Inflammatory Response of Mouse Skin Exposed to the Very Potent Carcinogen Dibenzo[a,l]pyrene: A Model for Tumor Promotion☆

1997 • 21 citations

Measurement of unscheduled DNA synthesis hi primary cultures of adult mouse epidermal keratinocytes

1988 • 20 citations

Transgenic Approaches to the Analysis of ras and p53 Function in Multistage Carcinogenesis

1994 • 19 citations

Relationship between DNA adduct formation and unscheduled DNA synthesis (UDS) in cultured mouse epidermal keratinocytes

1991 • 15 citations

Workshop on processing of DNA damage

1996 • 13 citations

Relationship between adduct formation, rates of excision repair and the cytotoxic and mutagenic effects of structurally-related polycyclic aromatic carcinogens

1997 • 13 citations

Linear Amplification Mapping of Polycyclic Aromatic Hydrocarbon-Reactive Sequences in H-rasGene

1998 • 12 citations

DNA Strand Breaks Induced by Configurationally Isomeric Hydrocarbon Diol Epoxides

1994 • 8 citations

Benzo[a]pyrene site of contact mutagenicity in skin of Muta^TMMouse

1998 • 8 citations