A ‘specificity’ pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

A Fast Flexible Docking Method using an Incremental Construction Algorithm

1996 • 2,706 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications

1992 • 431 citations

xdlMAPMANandxdlDATAMAN– Programs for Reformatting, Analysis and Manipulation of Biomacromolecular Electron-Density Maps and Reflection Data Sets

1996 • 276 citations

Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor

1973 • 262 citations

A molecular mechanics force field for NAD+ NADH, and the pyrophosphate groups of nucleotides

1997 • 196 citations

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

1992 • 193 citations

Diabetic Cataracts and Flavonoids

1977 • 189 citations

Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.

1993 • 159 citations

Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat

1985 • 148 citations

Purification and Characterization of Human‐Brain Aldose Reductase

1982 • 140 citations

An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for the Binding of Citrate, Cacodylate, and Glucose 6-Phosphate

1994 • 135 citations

N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor

1984 • 118 citations

Mechanism of Human Aldehyde Reductase: Characterization of the Active Site Pocket

1995 • 117 citations

Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding.

1992 • 105 citations

The crystal structure of the aldose reductase.NADPH binary complex.

1992 • 101 citations

Human Brain Aldehyde Reductases: Relationship to Succinic Semialdehyde Reductase and Aldose Reductase

1980 • 93 citations

The crystal structure of the aldose reductase.NADPH binary complex.

1992 • 88 citations

Molecular cloning of testicular 20.alpha.-hydroxysteroid dehydrogenase: Identity with aldose reductase

1993 • 87 citations

Mechanism of Aldose Reductase Inhibition: Binding of NADP+/NADPH and Alrestatin-like Inhibitors

1994 • 77 citations

Mechanistic basis for nonlinear kinetics of aldehyde reduction catalyzed by aldose reductase

1990 • 68 citations

Aldose reductase inhibitors: Recent developments

1993 • 62 citations

Synthesis, absolute configuration and conformation of the aldose reductase inhibitor sorbinil

1985 • 60 citations

Properties of an Aldose Reductase from Pig Lens

1982 • 55 citations

Aldose Reductase as a Target for Drug Design: Molecular Modeling Calculations on the Binding of Acyclic Sugar Substrates to the Enzyme

1995 • 41 citations

Medicinal chemistry of aldose reductase inhibitors

1988 • 38 citations

Kinetic and Spectroscopic Evidence for Active Site Inhibition of Human Aldose Reductase^,

1996 • 35 citations

A procedure compatible withX-PLORfor the calculation of electron-density maps weighted using anR-free-likelihood approach

1996 • 34 citations

Current progress in clinical trials of aldose reductase inhibitors in Japan

1990 • 28 citations

(2,6-dimethylphenylsulphonyl)nitromethane: A new structural type of aldose reductase inhibitor which follows biphasic kinetics and uses an allosteric binding site

1991 • 17 citations

Kinetic characteristics of zeneca ZD5522, a potent inhibitor of human and bovine lens aldose reductase

1995 • 14 citations

Aldose Reductase from Pig Lens

1995 • 11 citations

Purification and electrospray mass spectrometry of aldose reductase from pig lens

1992 • 6 citations

Deleted Work

1955 • 0 citations