Dynamic simulation of pharmacokinetic systems using the electrical circuit analysis program SPICE2

Computer-Aided Analysis of Electronic Circuits: Algorithms and Computational Techniques

1975 • 853 citations

A program package for simulation and parameter estimation in pharmacokinetic systems

1979 • 483 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Network thermodynamics: dynamic modelling of biophysical systems

1973 • 344 citations

Fundamentals of Clinical Pharmacokinetics

1976 • 257 citations

Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

1977 • 221 citations

Pharmacokinetics of Acetylsalicylic Acid and Salicylic Acid After Intravenous Administration in Man

1968 • 178 citations

Salicylate Accumulation Kinetics in Man

1972 • 174 citations

Conversational SAAM—an interactive program for kinetic analysis of biological systems

1981 • 171 citations

Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics.

1979 • 78 citations

Thermodynamic Network Analysis of Biological Systems

1977 • 70 citations

Physiologically Based Pharmacokinetic Model for Digoxin Distribution and Elimination in the Rat

1977 • 66 citations

Relationship between Dose and Plateau Levels of Drugs Eliminated by Parallel First-Order and Capacity-Limited Kinetics

1972 • 63 citations

AUTOMOD: A polyalgorithm for an integrated analysis of linear pharmacokinetic models

1979 • 51 citations

A network thermodynamic model of glomerular dynamics: Application in the rat

1981 • 39 citations

Network modelling of reaction-diffusion systems and their numerical solution using spice

1980 • 38 citations

A simple network thermodynamic method for modeling series-parallel coupled flows I. The linear case

1977 • 38 citations

A Network Thermodynamic Approach to Compartmental Analysis

1979 • 33 citations

A network thermodynamic two-port element to represent the coupled flow of salt and current. Improved alternative for the equivalent circuit

1979 • 30 citations

Mathematical Model of Sustained-Release Preparations and Its Analysis

1966 • 29 citations

Network representation of reaction-diffusion systems far from equilibrium

1978 • 28 citations

Analog Computer in Drug Dosage and Formulation Design

1966 • 22 citations

Some network thermodynamic models of coupled, dynamic physiological systems

1979 • 21 citations

MacDope: A simulation of drug disposition in the human body. Mathematical considerations

1980 • 20 citations

'MacDope': a simulation of drug disposition in the human body: applications in clinical pharmacokinetics.

1980 • 15 citations

Compartmental analysis—I: LINDE, a program using an analytical method of integration with constituent matrices

1979 • 13 citations

Formulation and Computation of Compartment Models

1970 • 11 citations

Physiological flow model for drug elimination interactions in the rat

1980 • 11 citations

Periodicity during the distributive phase for drugs administered intravenously to humans.

1979 • 10 citations

Compartmental analysis—II: ACT, a program for compartmental models of the generalized Michaelis-Menten type

1979 • 8 citations

Analogcomputer in Chemie und Biologie

1969 • 8 citations

Use of simulation to develop multiple-dose regimens for drugs exhibiting nonlinear elimination kinetics

1980 • 3 citations