Disorders of Phagocyte Chemotaxis

Functions of Lysosomes

1966 • 2,942 citations

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

A Human Syndrome Caused by Immotile Cilia

1976 • 1,235 citations

Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis

1977 • 1,014 citations

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors.

1977 • 905 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

1977 • 696 citations

The Immotile-Cilia Syndrome

1977 • 635 citations

EXTREME HYPERIMMUNOGLOBULINEMIA E AND UNDUE SUSCEPTIBILITY TO INFECTION

1972 • 589 citations

STUDIES ON CILIA

1968 • 562 citations

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes.

1977 • 541 citations

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.

1978 • 512 citations

ORIGIN OF GRANULES IN POLYMORPHONUCLEAR LEUKOCYTES

1966 • 476 citations

BIOCHEMICAL AND MORPHOLOGICAL CHARACTERIZATION OF AZUROPHIL AND SPECIFIC GRANULES OF HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES

1974 • 427 citations

THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO

1965 • 404 citations

The Chediak-Higashi syndrome: studies in four patients and a review of the literature.

1972 • 398 citations

Defective polymorphonuclear leukocyte function in a human periodontal disease

1977 • 381 citations

Effect of Cyclic AMP on Release of Lysosomal Enzymes from Phagocytes

1971 • 380 citations

DIFFERENCES IN ENZYME CONTENT OF AZUROPHIL AND SPECIFIC GRANULES OF POLYMORPHONUCLEAR LEUKOCYTES

1968 • 374 citations

Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.

1977 • 356 citations

Demonstration of a receptor on rabbit neutrophils for chemotactic peptides

1977 • 345 citations

Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

1974 • 340 citations

DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS

1960 • 337 citations

THE REGULATORY ROLE OF DIVALENT CATIONS IN HUMAN GRANULOCYTE CHEMOTAXIS

1974 • 334 citations

RAISED SERUM-IgE LEVELS AND DEFECTIVE NEUTROPHIL CHEMOTAXIS IN THREE CHILDREN WITH ECZEMA AND RECURRENT BACTERIAL INFECTIONS

1974 • 329 citations

Granulocyte Chemotaxis: An Improved in Vitro Assay Employing 51Cr-Labeled Granulocytes

1973 • 328 citations

Profound Neutropenia During the Early Phase of Hemodialysis

1968 • 324 citations

Defective granulocyte chemotaxis in the Chediak-Higashi syndrome

1971 • 319 citations

Increased Susceptibility to Infection Associated with Abnormalities of Complement-Mediated Functions and of the Third Component of Complement (C3)

1970 • 316 citations

RESOLUTION OF GRANULES FROM RABBIT HETEROPHIL LEUKOCYTES INTO DISTINCT POPULATIONS BY ZONAL SEDIMENTATION

1969 • 311 citations

Transport of sodium, potassium, and calcium across rabbit polymorphonuclear leukocyte membranes. Effect of chemotactic factor.

1977 • 310 citations

Cilia with Defective Radial Spokes

1979 • 303 citations

Lack of dynein arms in immotile human spermatozoa.

1975 • 301 citations

Bacterial factors chemotactic for polymorphonuclear leukocytes.

1968 • 296 citations

Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis.

1976 • 289 citations

Secretory Responses of Human Neutrophils: Exocytosis of Specific (Secondary) Granules by Human Neutrophils during Adherence in vitro and during Exudation in vivo

1979 • 286 citations

Correction of Leukocyte Function in Chediak-Higashi Syndrome by Ascorbate

1976 • 286 citations

Structural analysis of human neutrophil migration: Centriole, microtubule, and microfilament orientation and function during chemotaxis

1977 • 280 citations

SEQUENTIAL DEGRANULATION OF THE TWO TYPES OF POLYMORPHONUCLEAR LEUKOCYTE GRANULES DURING PHAGOCYTOSIS OF MICROORGANISMS

1973 • 272 citations

DEFECT IN NEUTROPHIL GRANULOCYTE CHEMOTAXIS IN JOB'S SYNDROME OF RECURRENT "COLD" STAPHYLOCOCCAL ABSCESSES

1974 • 267 citations

The selective eosinophil chemotactic activity of histamine.

1975 • 267 citations

Defective neutrophil chemotaxis in juvenile periodontitis

1977 • 266 citations

Neutrophil Actin Dysfunction and Abnormal Neutrophil Behavior

1974 • 266 citations

Chemotaxis by polymorphonuclear leukocytes

1978 • 255 citations

INTERACTION OF CELLS WITH IMMUNE COMPLEXES: ADHERENCE, RELEASE OF CONSTITUENTS, AND TISSUE INJURY

1971 • 255 citations

C5 Chemotactic Fragments Produced by an Enzyme in Lysosomal Granules of Neutrophils

1970 • 246 citations

THE DEACTIVATION OF RABBIT NEUTROPHILS BY CHEMOTACTIC FACTOR AND THE NATURE OF THE ACTIVATABLE ESTERASE

1968 • 244 citations

A PREALBUMIN ACTIVATOR OF PREKALLIKREIN

1972 • 244 citations

Abnormalities in the Regulation of Human IgE Synthesis

1978 • 242 citations

Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response.

1971 • 225 citations

Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes.

1977 • 215 citations

THE INFLUENCE OF PHAGOCYTOSIS ON THE INTRACELLULAR DISTRIBUTION OF GRANULE-ASSOCIATED COMPONENTS OF POLYMORPHONUCLEAR LEUCOCYTES

1960 • 209 citations

Changes in Lymphocyte Activity after Thermal Injury

1979 • 200 citations

Mechanisms of sensing chemical gradients by polymorphonuclear leukocytes

1974 • 198 citations

Generation of C5-Derived Lysosomal Enzyme-Releasing Activity (C5a) by Lysates of Leukocyte Lysosomes

1974 • 197 citations

Chemotactic Function in the Human Neonate: Humoral and Cellular Aspects

1971 • 194 citations

Role of secretory events in modulating human neutrophil chemotaxis.

1978 • 193 citations

BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVO

1971 • 185 citations

Regulation of homocytotropic antibody formation in the rat. 3. Effect of thymectomy and splenectomy.

1971 • 183 citations

Defective Regulation of Inflammatory Mediators in Hodgkin's Disease

1974 • 180 citations

Interaction of chemotactic factors with human macrophages: induction of transmembrane potential changes

1977 • 174 citations

Familial Neutrophil Chemotaxis Defect, Recurrent Bacterial Infections, Mucocutaneous Candidiasis, and Hyperimmunoglobulinemia E

1975 • 172 citations

Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis.

1978 • 169 citations

SOME PROPERTIES OF BOUND AND SOLUBLE DYNEIN FROM SEA URCHIN SPERM FLAGELLA

1972 • 168 citations

Cationic proteins of human granulocytes. VI. Effects on the complement system and mediation of chemotactic activity.

1975 • 164 citations

A Sequential, Prospective Analysis of Immunologic Abnormalities and Infection Following Severe Thermal Injury

1978 • 163 citations

Separation and characterization of human neutrophil granules.

1974 • 163 citations

Fletcher factor deficiency. A diminished rate of Hageman factor activation caused by absence of prekallikrein with abnormalities of coagulation, fibrinolysis, chemotactic activity, and kinin generation.

1974 • 159 citations

2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect.

1976 • 158 citations

Defective Neutrophil Chemotaxis and Cellular Immunity in a Child with Recurrent Infections

1973 • 157 citations

Staphylococcal IgE Antibodies, Hyperimmunoglobulinemia E andStaphylococcus aureusInfections

1979 • 150 citations

A NEUTROPHIL-IMMOBILIZING FACTOR DERIVED FROM HUMAN LEUKOCYTES

1972 • 148 citations

Polymorphonulcear leukocyte chemotaxis toward oxidized lipid components of cell membranes.

1975 • 145 citations

THE MOBILIZATION AND EXTRACELLULAR RELEASE OF GRANULAR ENZYMES FROM HUMAN LEUKOCYTES DURING PHAGOCYTOSIS

1972 • 144 citations

Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome.

1976 • 141 citations

Chemotactic Factor Inactivator in Normal Human Serum

1973 • 140 citations

Immunoglobulin E in immunologic deficiency diseases. II. Serum IgE concentration of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wiskott-Aldrich syndrome.

1972 • 138 citations

The differential mobilization of human neutrophil granules. Effects of phorbol myristate acetate and ionophore A23187.

1977 • 136 citations

Separation and functional characterization of human neutrophil subpopulations

1978 • 132 citations

CHANGES IN IMMUNOGLOBULIN LEVELS IN SEVERELY BURNED PATIENTS

1969 • 131 citations

Immunologic reactivity of the lung: the in vivo and in vitro generation of a neutrophil chemotactic factor by alveolar macrophages.

1978 • 131 citations

Regulation of homocytotropic antibody formation in the rat. II. Effect of X-irradiation.

1971 • 124 citations

Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes. Effects of phorbol myristate acetate.

1975 • 123 citations

Evaluation of Leukocyte Chemotaxis In Vitro in Thermally Injured Patients

1974 • 119 citations

Neutrophil dysfunction and sepsis in burn injury.

1970 • 119 citations

Selective labilization of specific granules in polymorphonuclear leukocytes by phorbol myristate acetate.

1974 • 118 citations

A Functional Differentiation of Human Neutrophil Granules: Generation of C5a by a Specific (Secondary) Granule Product and Inactivation of C5a by Azurophil (Primary) Granule Products

1977 • 117 citations

Situs Inversus Totalis and Kartagener's Syndrome in a Japanese Population

1972 • 116 citations

Degranulating Stimuli Decrease the Negative Surface Charge and Increase the Adhesiveness of Human Neutrophils

1980 • 113 citations

The Effect of Thermal Injury on Serum Immunoglobulins

1970 • 112 citations

Analogous ultrastructure and surface properties during capping and phagocytosis in leukocytes

1978 • 111 citations

Evidence of congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects.

1975 • 108 citations

Studies on Neutrophil Function. II. PATHOLOGICAL ASPECTS

1966 • 101 citations

Intracellular and Extracellular Degranulation of Human Polymorphonuclear Azurophil and Specific Granules Induced by Immune Complexes

1974 • 100 citations

Biochemistry of Phagocyte Chemotaxis

1979 • 99 citations

The Role of Lysosomes in Immune Responses

1970 • 98 citations

Abnormalities of Chemotactic Lymphokine Synthesis and Mononuclear Leukocyte Chemotaxis in Wiskott-Aldrich Syndrome

1974 • 95 citations

THYMIC ALYMPHOPLASIA WITH HYPER-IgE-GLOBULINEMIA

1973 • 89 citations

Effects of levamisole on normal and abnormal leukocyte locomotion.

1977 • 85 citations

Demonstration of the Chemotactic Properties of Collagen

1970 • 84 citations

Defective regulation of chemotaxis in cirrhosis.

1975 • 83 citations

Changes in Humoral Components of Host Defense Following Burn Trauma

1977 • 82 citations

Leukotactic Dysfunction in Sarcoidosis

1976 • 81 citations

Kinetic analysis of chemotactic factor generation in human serum via activation of the classical and alternate complement pathways

1975 • 81 citations

Defective leukotaxis in patients with lepromatous leprosy.

1976 • 75 citations

LEUKOTACTIC FACTORS ELABORATED BY VIRUS-INFECTED TISSUES

1972 • 75 citations

Neutrophil function in surgical patients: Two inhibitors of granulocyte chemotaxis associated with sepsis

1979 • 74 citations

The identification of Fc and C3 receptors on human neutrophils

1975 • 74 citations

Improvement of Chediak-Higashi leukocyte function by cyclic guanosine monophosphate

1977 • 72 citations

The Fibrinolytic Pathway of Human Plasma II. THE GENERATION OF CHEMOTACTIC ACTIVITY BY ACTIVATION OF PLASMINOGEN PROACTIVATOR

1973 • 69 citations

Neutrophil chemotaxis in systemic lupus erythematosus.

1974 • 67 citations

A Proposal for the Definition of Terms Related to Locomotion of Leukocytes and Other Cells

1978 • 66 citations

Suppression of Leukocyte Chemotaxis in vitro by Chemotherapeutic Agents Used in the Management of Thermal Injuries

1975 • 66 citations

Functional changes in neutrophils collected by filtration leukapheresis and their relationship to cellular events that occur during adherence of neutrophils to nylon fibers.

1979 • 65 citations

ALTERED NEUTROPHIL PHAGOCYTIC FUNCTION IN BURN PATIENTS

1976 • 65 citations

Polymorphonuclear leukocyte and monocyte chemoattractants produced by human fibroblasts.

1979 • 63 citations

Characterization of serum inhibitors of neutrophil chemotaxis associated with anergy.

1974 • 63 citations

IgE in immunodeficiency.

1972 • 60 citations

T lymphocyte dysfunction, hyperimmunoglobulinemia E, recurrent bacterial infections, and defective neutrophil chemotaxis in a Negro child

1976 • 59 citations

SERUM PROTEIN PROFILES IN THERMAL BURNS II. Protease Inhibitors, Complement Factors, and C-Reactive Protein

1974 • 59 citations

Demonstration of a specific neutrophil receptor for a cell-derived chemotactic factor.

1979 • 58 citations

Release of vitamin B12—binding protein by human leukocytes in vitro

1970 • 58 citations

Regulation of homocytotropic antibody formation in the rat. V, Cell cooperation in the anti-hapten homocytotropic antibody response.

1971 • 57 citations

Depressed Mononuclear Leukocyte Chemotaxis in Thermally Injured Patients

1977 • 56 citations

Leukocytes as Secretory Organs of Inflammation

1978 • 55 citations

Suppressor T-cell activity induced as a result of thermal injury

1979 • 55 citations

Structural determinants of the eosinophil: chemotactic activity of the acidic tetrapeptides of eosinophil chemotactic factor of anaphylaxis.

1976 • 54 citations

Periodic variation in the antibacterial function of human neutrophils and its relationship to sepsis.

1971 • 52 citations

Modulation of the inflammatory response by products released from human polymorphonuclear leukocytes during phagocytosis

1975 • 51 citations

Serum protein profiles in thermal burns. I. Serum electrophoretic patterns, immunoglobulins, and transport proteins.

1974 • 50 citations

Deficiency of the Chemotactic Factor Inactivator in Human Sera with α1-Antitrypsin Deficiency

1973 • 45 citations

A reappraisal of Kartagener's syndrome.

1968 • 44 citations

SUPPRESSED IN VITRO CHEMOTAXIS OF BURN NEUTROPHILS

1976 • 43 citations

Recurrent severe infections in a child with abnormal leukocyte function: possible relationship to increased microtubule assembly

1978 • 42 citations

Study of lymphocyte depletion and serum complement perturbations following acute burn trauma.

1973 • 41 citations

TRANSPOSITION OF THE VISCERA AND STERILITY IN MEN

1960 • 40 citations

Enhancement of Neutrophil Chemotaxis and Alteration of Levels of Cellular Cyclic Nudeotides by Levamisole

1978 • 39 citations

Neutrophil Chemotaxis in Patients with Burns

1977 • 39 citations

Host Defense Against Opportunist Microorganisms Following Trauma

1978 • 37 citations

Fibroblasts and macrophages of mice with the Chediak-Higashi-like syndrome have microtubules and actin cables.

1978 • 37 citations

Thermal Injury-Associated Immunosuppression: Occurrence and in vitro Blocking Effect of Post Recovery Serum

1979 • 36 citations

Alterations of serum opsonins in patients with severe thermal injury.

1974 • 35 citations

MIXED LYMPHOCYTE CULTURE REACTION IN PATIENTS WITH ACUTE THERMAL BURNS

1974 • 34 citations

Correction of characteristic abnormalities of microtubule function and granule morphology in chediak-higashi syndrome with cholinergic agonists. Studies in vitro in man and in vivo in the beige mouse.

1976 • 34 citations

EVALUATION OF LEUKOCYTE FUNCTION IN BURNED INDIVIDUALS BY IN VITRO OXYGEN CONSUMPTION

1975 • 33 citations

A Familial Defect of Neutrophil Chemotaxis with Asthma, Eczema, and Recurrent Skin Infections

1977 • 32 citations

POLYMORPHONUCLEAR LEUKOCYTE Fc RECEPTORS IN ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC)

1976 • 28 citations

REDUCTION IN C3 CONVERSION IN PATIENTS WITH SEVERE THERMAL INJURY

1976 • 26 citations

Chemotaxis in Acute Renal Failure

1972 • 25 citations

T Lymphocyte Rosette Formation After Major Burns

1977 • 24 citations

Generation of chemotactic factors in guinea pig serum via activation of the classical and alternate complement pathways

1973 • 23 citations

Mobilization and exocytosis of specific (secondary) granules by human neutrophils during adherence to nylon wood in filtration leukapheresis (FL)

1978 • 23 citations

Deficiencies of the complement system in man.

1975 • 21 citations

The Role of NADH-NADPH Oxidase Activity in the Leukocyte Function of Burned Patients

1979 • 21 citations

Decreased opsonic and chemotactic activities in sera of postburn patients and partial opsonic restoration with properdin and properdin convertase

1978 • 19 citations

Intrinsic defect of the polymorphonuclear leukocyte resulting in impaired chemotaxis and phagocytosis

1971 • 19 citations

Functional Anatomy of the Kidney

1978 • 13 citations

Quantification of serum IgE in patients with burns

1979 • 10 citations

Selective hypogammaglobulinemia with persistence of lgE, malabsorption and a nutritionally dependent, reversible defect in cell-mediated immunity

1975 • 4 citations

Chemotactic activity of fibrinopeptides.

1973 • 1 citations

Deleted Work

1955 • 0 citations