Molecular and biological factors in the pathogenesis of ovarian cancer

p53 Mutations in Human Cancers

1991 • 8,133 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Growth Factors and Cancer

1991 • 2,044 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Cancer statistics, 1990

1990 • 818 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer

1990 • 571 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6.

1990 • 500 citations

Overexpression and mutation of p53 in epithelial ovarian cancer.

1991 • 464 citations

Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1989 • 420 citations

Practical gynecologic oncology

1989 • 372 citations

[Prognostic factors in patients with stage I epithelial ovarian cancer].

1994 • 353 citations

Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.

1990 • 350 citations

IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.

1989 • 307 citations

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β ₂ (BSF-2, IL-6)

1988 • 281 citations

Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures.

1990 • 226 citations

Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer

1991 • 214 citations

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

1991 • 201 citations

Prognostic significance of dna index, multiploidy, and S-phase fraction in ovarian cancer

1988 • 194 citations

Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.

1991 • 194 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1.

1990 • 147 citations

Conservative treatment of borderline ovarian tumors.

1985 • 143 citations

Constitutive production of macrophage colony-stimulating factor by human ovarian and breast cancer cell lines.

1989 • 135 citations

Randomized trial comparing cisplatin with radioactive phosphorus or whole-abdomen irradiation as adjuvant treatment of Ovarian cancer

1992 • 131 citations

c-myc amplification in ovarian cancer

1990 • 127 citations

Ploidy as a Prognostic Factor in Ovarian Cancer

1983 • 126 citations

Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers

1992 • 124 citations

Prediction of long-term survival by flow cytometric analysis of cellular DNA content in patients with advanced ovarian cancer.

1988 • 123 citations

Borderline ovarian tumors

1988 • 106 citations

Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-α

1992 • 102 citations

Prognostic significance of nuclear DNA content in serous ovarian tumors.

1984 • 100 citations

Flow cytometric analysis of cellular DNA content as an adjunct to the diagnosis of ovarian tumours of borderline malignancy

1984 • 97 citations

Regulation of Expression of Interleukin‐6

1989 • 95 citations

Interleukin 10

1991 • 87 citations

Ovarian cancer, Part I: Biology

1992 • 80 citations

Is Stage I epithelial ovarian cancer overtreated both surgically and systemically? Results of a five‐year cancer registry review

1992 • 78 citations

Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products.

1988 • 76 citations

Detection of interleukin-6 in human follicular fluid

1992 • 73 citations

A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinomas

1988 • 72 citations

Constitutive Production of Macrophage Colony-Stimulating Factor and Interleukin-6 by Human Ovarian Surface Epithelial Cells

1993 • 71 citations

Ploidy assessment of benign and malignant ovarian tumors by flow cytometry. A clinicopathologic study

1987 • 68 citations

The clinical significance of pre‐operative serum CA 125 in ovarian cancer

1987 • 67 citations

Clinical significance of abnormal nuclear DNA content in serous ovarian tumors

1988 • 65 citations

Resistance of human ovarian cancer cells to tumor necrosis factor and lymphokine-activated killer cells: correlation with expression of HER2/neu oncogenes.

1990 • 63 citations

The prognostic significance of nuclear DNA content in malignant epithelial tumors of the ovary

1990 • 63 citations

Allele Loss at the Retinoblastoma Locus in Human Ovarian Cancer

1991 • 61 citations

Flow cytometric analysis of DNA content in human ovarian cancers

1989 • 58 citations

Prognostic value of the flow cytometric DNA index in human ovarian carcinoma

1988 • 58 citations

The prognostic value of morphometrical features and cellular DNA content in cis-platin treated late ovarian cancer patients

1988 • 52 citations

Serum CA 125 in epithelial ovarian cancer. A longitudinal study

1987 • 52 citations

Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)

1988 • 51 citations

Suppression of carcinogenesis: a role for TGF-beta and related molecules in prevention of cancer.

1990 • 48 citations

The prognostic variability of ovarian tumor grading by different pathologists

1987 • 48 citations

Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma

1987 • 48 citations

DNA flow cytometry, clinical and morphological parameters as prognostic factors for advanced malignant and borderline ovarian tumors

1989 • 46 citations

Pretreatment serum levels of CA-125, carcinoembryonic antigen, tissue polypeptide antigen, and placental alkaline phosphatase in patients with ovarian carcinoma: Influence of histological type, grade of differentiation, and clinical stage of disease

1990 • 45 citations

Influence of cellular DNA content on survival in ovarian carcinoma.

1989 • 45 citations

Amplification of c‐ras‐ki oncogene in human ovarian tumours

1989 • 44 citations

Flow cytometric analysis of nuclear DNA content in ovarian tumors association of ploidy with tumor type, histologic grade, and clinical stage

1992 • 43 citations

Growth Inhibition of Ovarian Cancer Cells Induced by Antisense IL-6 Oligonucleotides

1993 • 42 citations

Lymphocyte cytotoxicity in the peritoneal cavity and blood of patients with ovarian cancer.

1984 • 42 citations

Suppression of programmed death and G₁ arrest in B‐cell hybridomas by interleukin‐6 is not accompanied by altered expression of immediate early response genes

1990 • 41 citations

Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: Up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-α

1994 • 37 citations

Evaluation of the prognostic value of morphometric features and cellular DNA content in FIGO I ovarian cancer patients.

1987 • 33 citations

Immunohistochemical detection of the ras oncogene product p21 in advanced ovarian cancer. Lack of correlation with clinical outcome.

1988 • 30 citations

Ovarian Malignancies–Diagnostic and Therapeutic Advances

1988 • 28 citations

Oncogenes in Ovarian Cancer

1992 • 25 citations

Nuclear DNA content of borderline tumors of the ovary: Correlation with histology and significance for prognosis

1986 • 25 citations

Differential effects of an immunosuppressive fraction from ascites fluid of patients with ovarian cancer on spontaneous and antibody-dependent cytotoxicity.

1981 • 24 citations

Proposal for therapeutic approach based on prognostic factors including morphometric and flow-cytometric features in stage iii-iv ovarian cancer

1988 • 20 citations

The immunobiology and immunotherapy of ovarian cancer.

1991 • 19 citations

Tumour suppressor genes.

1989 • 14 citations

Tumour ploidy, morphometry, histological grading and clinical features in ovarian carcinoma: mutual relations.

1991 • 13 citations

Interleukin 6 and cancer treatment.

1991 • 13 citations

Oncogene and growth factor expression in ovarian cancer

1992 • 13 citations

Immunohistochemical detection of CA-125 and carcinoembryonic antigen in ovarian tumors in relation to corresponding preoperative serum levels

1992 • 11 citations

Biologic and Immunologic Therapy of Ovarian Cancer

1992 • 11 citations

C-MYB activation and the pathogenesis of ovarian cancer.

1992 • 9 citations

Interleukin-2 and cancer therapy.

1990 • 6 citations

Deleted Work

1955 • 0 citations