A Recombinant Insect‐Specific α‐Toxin of Buthus occitanus tunetanus Scorpion Confers Protection Against Homologous Mammal Toxins
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Abstract
References (60)
Molecular Cloning: A Laboratory Manual
2001 • 133,517 citations
DNA sequencing with chain-terminating inhibitors
1977 • 69,181 citations
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12
1938 • 19,183 citations
Studies on transformation of Escherichia coli with plasmids
1983 • 11,179 citations
A simple method of estimating 50 per cent end points
1938 • 8,381 citations
Ionic channels of excitable membranes
1985 • 7,199 citations
A complementation analysis of the restriction and modification of DNA in Escherichia coli
1969 • 3,866 citations
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
1984 • 3,334 citations
3′ Non-coding region sequences in eukaryotic messenger RNA
1976 • 3,001 citations
A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.
1983 • 933 citations
A synthetic IgG-binding domain based on staphylococcal protein A
1987 • 735 citations
MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE SODIUM CHANNELS
1986 • 577 citations
Purification of Animal Neurotoxins
1970 • 348 citations
The Molecular Basis of Neuronal Excitability
1984 • 346 citations
Progress in the characterization of venoms and standardization of antivenoms
1981 • 312 citations
Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel
1982 • 266 citations
Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes
1980 • 242 citations
Scorpion toxins: chemistry and mode of action.
1979 • 200 citations
Proceedings: Selective inhibition of potassium current in the giant axon of the cockroach.
1974 • 172 citations
A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action
1990 • 165 citations
Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector.
1988 • 159 citations
Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis.
1993 • 153 citations
Genetic Engineering of Snake Toxins
1995 • 151 citations
An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site
1985 • 147 citations
Purification and properties of the insect toxin from the venom of the scorpion Androctonus australis Hector
1971 • 143 citations
Functional duality and structural uniqueness of the depressant insect-selective neurotoxins
1991 • 133 citations
Membrane potential dependent binding of scorpion toxin to action potential Na+ ionophore.
1976 • 130 citations
Precursors of Androctonus australis scorpion neurotoxins
1989 • 128 citations
A gene fusion system for generating antibodies against short peptides
1987 • 123 citations
Three-dimensional structure of a protein from scorpion venom: a new structural class of neurotoxins.
1980 • 120 citations
Synthesis of a gene coding for an insect-specific scorpion neurotoxin and attempts to express it using baculovirus vectors
1988 • 118 citations
Tityus serrulatus toxin VII bears pharmacological properties of both β-toxin and insect toxin from scorpion venoms
1986 • 100 citations
Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana)
1982 • 97 citations
Scorpion venoms and neurotoxins: An immunological study
1981 • 88 citations
The binding of the insect selective neurotoxin (AaIT) from scorpion venom to locust synaptosomal membranes
1984 • 87 citations
Pharmacological properties of insect axons: A review
1982 • 82 citations
In vivo protection against scorpion toxins by liposomal immunization
1991 • 74 citations
Purification, characterization and action of two insect toxins from the venom of the scorpion buthotus judaicus
1982 • 73 citations
Primary structure of scorpion anti‐insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus
1990 • 71 citations
Two-dimensional proton nuclear magnetic resonance study of Aah IT, an anti-insect toxin from the scorpion Androctonus australis Hector. Sequential resonance assignments and folding of the polypeptide chain
1991 • 68 citations
Binding of an α scorpion toxin to insect sodium channels is not dependent on membrane potential
1993 • 65 citations
A new toxic protein in the venom of the scorpion Androctonus australis Hector
1971 • 63 citations
Characterization of toxin III of the scorpion Leiurus quinquestriatus quinquestriatus: A new type of alpha‐toxin highly toxic both to mammals and insects
1993 • 62 citations
Action of different toxins from the scorpion Androctonus australis on a locust nerve-muscle preparation
1976 • 61 citations
Current-Voltage Relations in the Isolated Giant Axon of the Cockroach Under Voltage-Clamp Conditions*
1967 • 59 citations
Direct expression in E.coli of a functionally active protein A–snake toxin fusion protein
1989 • 58 citations
Differential effects of defined chemical modifications on antigenic and pharmacological activities of scorpion alpha and beta toxins
1986 • 50 citations
Immunochemistry of scorpion α-neurotoxins. Determination of the antigenic site number and isolation of a highly enriched antibody specific to a single antigenic site of toxin II ofAndroctonus australis Hector
1983 • 44 citations
Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector
1985 • 43 citations
Immunochemistry of scorpion α-toxins: Antigenic homologies checked with radioimmunoassays (RIA)
1983 • 42 citations
Expression of a gene encoding a scorpion insectotoxin peptide in yeast, bacteria and plants
1992 • 37 citations
On the site by which α‐dendrotoxin binds to voltage‐dependent potassium channels: Site‐directed mutagenesis reveals that the lysine triplet 28–30 is not essential for binding
1994 • 36 citations
Covalent structure of toxins I and II from the scorpion Buthus occitanus tunetanus
1983 • 33 citations
Production of active, insect‐specific scorpion neurotoxin in yeast
1994 • 32 citations
Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei
1987 • 32 citations
Functional expression and site-directed mutagenesis of a synthetic gene for alpha-bungarotoxin
1994 • 29 citations
A recombinant snake neurotoxin generated by chemical cleavage of a hybrid protein recovers full biological properties
1990 • 29 citations
Expression and Secretion of a Functional Scorpion Insecticidal Toxin in Cultured Mouse Cells
1990 • 27 citations
Production of recombinant notechis 11′2L, an enzymatically active mutant of a phospholipase A2 from Notechis scutatus scutatus venom, as directly generated by cleavage of a fusion protein produced in Escherichia coli
1993 • 18 citations
Expression of an active alpha scorpion neurotoxin using Escherichia coli, insect cells and lepidopterous larvae: structure-activity relationship and future applications
1995 • 2 citations