DNA Organization Affects Cellular Radiosensitivity and Detection of Initial DNA Strand Breaks

Role of cell shape in growth control

1978 • 2,434 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

1979 • 577 citations

Supercoils in human dna

1975 • 496 citations

Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus

1986 • 436 citations

DNA double-strand breaks measured in individual cells subjected to gel electrophoresis.

1991 • 330 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

DNA precipitation assay: A rapid and simple method for detecting DNA damage in mammalian cells

1988 • 323 citations

Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions.

1989 • 317 citations

The Level of Induced DNA Double-strand Breakage Correlates with Cell Killing after X-irradiation

1985 • 316 citations

The Yield of DNA Double-strand Breaks Produced Intracellularly by Ionizing Radiation: A Review

1990 • 312 citations

Effects of intercellular contact on repair of radiation damage

1972 • 287 citations

Heterogeneous DNA damage and repair in the mammalian genome.

1987 • 274 citations

Cancer as a disease of DNA organization and dynamic cell structure.

1989 • 258 citations

Biochemical basis for the interactions of type I and type II topoisomerases with DNA

1989 • 251 citations

DNA repair and the role of chromatin structure

1991 • 218 citations

Animal cell shape changes and gene expression

1991 • 212 citations

Functions of intermediate filaments

1989 • 178 citations

The Repair of Double-Strand DNA Breaks Correlates with Radiosensitivity of L5178Y-S and L5178Y-R Cells

1987 • 177 citations

Formation of nascent DNA molecules during inhibition of replicon initiation in mammalian cells

1976 • 173 citations

Spatial and temporal distribution of DNA replication sites localized by immunofluorescence and confocal microscopy in mouse fibroblasts

1991 • 170 citations

Radiation-induced Single-strand Breaks in DNA Determined by Rate of Alkaline Strand Separation and Hydroxylapatite Chromatography: An Alternative to Velocity Sedimentation

1974 • 168 citations

Asymmetric Field Inversion Gel Electrophoresis: A New Method for Detecting DNA Double-Strand Breaks in Mammalian Cells

1990 • 150 citations

The nucleoskeleton: Artefact, passive framework or active site?

1988 • 143 citations

Induction and Rejoining of DNA Double-Strand Breaks in Human Cervix Carcinoma Cell Lines of Differing Radiosensitivity

1988 • 115 citations

Visualization of DNA loops in nucleoids from HeLa cells: Assays for DNA damage and repair

1987 • 104 citations

Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation

1982 • 103 citations

Hypothesis on Differentiation and the Inheritance of Gene Superstructure

1973 • 99 citations

Cell Proliferation as a Requirement for Development of the Contact Effect in Chinese Hamster V79 Spheroids

1989 • 96 citations

DNA-Bound Proteins Contribute Much More Than Soluble Intracellular Compounds to the Intrinsic Protection against Radiation-Induced DNA Strand Breaks in Human Cells

1991 • 92 citations

DNA repair mechanisms and their biological implications in mammalian cells

1989 • 87 citations

Comparison between Pulsed-field and Constant-field Gel Electrophoresis for Measurement of DNA Double-strand Breaks in Irradiated Chinese Hamster Ovary Cells

1991 • 78 citations

Variation through the Cell Cycle in the Dose-response of DNA Neutral Filter Elution in X-irradiated Synchronous CHO-cells

1988 • 71 citations

Techniques to Measure DNA Single-strand Breaks in Cells: A Review

1988 • 68 citations

Proteins Tightly Bound to HeLa Cell DNA at Nuclear Matrix Attachment Sites

1983 • 68 citations

Radiation-induced DNA Double-strand Break Frequencies in Human Squamous Cell Carcinoma Cell Lines of Different Radiation Sensitivities

1991 • 60 citations

Association among DNA/chromosome break rejoining rates, chromatin structure alterations, and radiation sensitivity in human tumor cell lines.

1989 • 59 citations

DNA Conformation of Chinese Hamster V79 Cells and Sensitivity to Ionizing Radiation

1986 • 58 citations

Radiosensitive Xrs-5 and Parental CHO Cells Show Identical DNA Neutral Filter Elution Dose—response: Implications for a Relationship between Cell Radiosensitivity and Induction of DNA Double-strand Breaks

1988 • 55 citations

Detection of Ionizing Radiation-Induced DNA Double-Strand Breaks by Filter Elution Is Affected by Nuclear Chromatin Structure

1990 • 48 citations

The Increase in Radioresistance of Chinese Hamster Cells Cultured as Spheroids Is Correlated to Changes in Nuclear Morphology

1990 • 47 citations

Principles of nuclear organization

1990 • 47 citations

Measurement of DNA Damage in Mammalian Cells Using Flow Cytometry

1987 • 45 citations

Differences in the DNA Supercoiling Response of Irradiated Cell Lines from Ataxia-telangiectasia Versus Unaffected Individuals

1991 • 45 citations

DNA Supercoiling Changes in Nucleoids from Irradiated L5178Y-S and -R Cells

1989 • 43 citations

Cell Cycle Effect on the Induction of DNA Double-Strand Breaks by X Rays

1988 • 42 citations

Proteins tightly bound to HeLa cell DNA at nuclear matrix attachment sites.

1983 • 41 citations

Effect of Cell-cycle Position and Dose on the Kinetics of DNA Double-strand Breakage Repair in X-irradiated Chinese Hamster Cells

1987 • 41 citations

The nuclear matrix: current concepts and unanswered questions.

1986 • 40 citations

Physical Basis for Detection of DNA Double-Strand Breaks Using Neutral Filter Elution

1990 • 40 citations

Changes in the Nuclear Structure in the Radiation-Sensitive CHO Mutant Cell, xrs-5

1991 • 34 citations

Interaction between ionizing radiation and supercoiled DNA within human tumor cells.

1991 • 32 citations

The effects of ionizing radiation on structure and function of DNA

1987 • 32 citations

Chromatin Compaction and the Efficiency of Formation of DNA-Protein Crosslinks in γ-Irradiated Mammalian Cells

1992 • 32 citations

Synthesis in vitro of Anti-Lepore Haemoglobin

1973 • 31 citations

A Comparison of the Induction of DNA Double-Strand Breakage and Lethal Lesions by X Irradiation in Ataxia Telangiectasia and Normal Fibroblasts

1990 • 27 citations

Neutral Filter Elution Detects Differences in Chromatin Organization Which Can Influence Cellular Radiosensitivity

1992 • 26 citations

Etoposide Sensitivity and Topoisomerase II Activity in Chinese Hamster V79 Monolayers and Small Spheroids

1991 • 25 citations

Relationship of DNA Tertiary and Quaternary Structure to Carcinogenic Processes

1982 • 25 citations

Radiation-Induced DNA Damage in V79 Spheroids and Monolayers

1979 • 22 citations

Use of ‘Nuclear Monolayers’ to Identify Factors Influencing DNA Double-Strand Breakage by X-rays

1987 • 20 citations

Radiation-Induced DNA Unwinding Is Influenced by Cell Shape and Trypsin

1992 • 15 citations

DNA Topoisomerases and Radiation Responses

1990 • 15 citations

The crosslinking of nuclear protein to DNA using ionizing radiation

1990 • 12 citations

Image analysis-based measurement of DNA supercoiling changes in transformed and nontransformed human cell lines

1991 • 12 citations

Resistance to DNA denaturation in irradiated Chinese hamster V79 fibroblasts is linked to cell shape

1991 • 10 citations

The Influence of Genome Structural Organization on DNA Damage and Repair in Eukaryotic Cells Exposed to Ionizing Radiation

1991 • 9 citations

Non-Random Distribution of UV-Induced Repair in Higher-Order Chromatin Loops in Human Cells and its Relationship to Preferential Repair of Active Genes

1989 • 6 citations

Influence of Membrane Lipid Composition and Organization on Radio-and Thermosensitivity of Bacteria

1987 • 2 citations

核骨格 人工産物,不活性の枠組それとも活性部位?

1988 • 1 citations