Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2-ylthio)carbapenems

Semianalytical treatment of solvation for molecular mechanics and dynamics

1990 • 3,585 citations

"Celbenin" - resistant Staphylococci

1961 • 1,651 citations

Applied Biopharmaceutics and Pharmacokinetics.

1981 • 1,335 citations

An internal-coordinate Monte Carlo method for searching conformational space

1989 • 1,067 citations

Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus

1984 • 871 citations

Cellbenin-resistant staphylococci.

1961 • 556 citations

Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus

1985 • 363 citations

Community-Acquired Methicillin-Resistant Staphylococcus aureus Infections: A New Source for Nosocomial Outbreaks

1982 • 311 citations

Occurrence of a beta-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci

1985 • 252 citations

N-Acetimidoyl- and N-formimidoylthienamycin derivatives: antipseudomonal .beta.-lactam antibiotics

1979 • 161 citations

SYNTHESES OF 1-N-{(S)-4-AMINO-2-HYDROXYBUTYRYL}-KANAMYCIN B AND -3'', 4''-DIDEOXYKANAMYCIN B ACTIVE AGAINST KANAMYCIN-RESISTANT BACTERIA

1973 • 143 citations

Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I

1992 • 131 citations

Recent advances in the chemistry of β-lactam antibiotics

1989 • 103 citations

Bile and Urine as Complementary Pathways for the Excretion of Foreign Organic Compounds

1976 • 101 citations

Methicillin-resistant strains ofStaphylococcus aureus; presence of identical additional penicillin-binding protein in all strains examined

1986 • 91 citations

Characterization of an isogenic set of methicillin-resistant and susceptible mutants ofStaphylococcus aureus

1986 • 69 citations

Synthetic carbapenem antibiotics III. 1-Methyl thienamycin

1985 • 69 citations

.beta.-Lactams. 3. Asymmetric total synthesis of new non-natural 1.beta.-methylcarbapenems exhibiting strong antimicrobial activities and stability against human renal dehydropeptidase-I

1992 • 65 citations

STAPHYLOCOCCAL SEPSIS The Changing Pattern of Disease and Therapy

1988 • 60 citations

Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus

1993 • 42 citations

Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus

1995 • 37 citations

MERCAPTOTHIAZOLES: OXIDATION AND ALKYLATION STUDIES

1941 • 33 citations

Tautomeric Cyclic Thiones. Part III. Preparation of N- and S-Methyl Derivatives of Some Azoline-2-thiones.

1969 • 27 citations

The synthesis of 2-(functionalized methyl)-1.BETA.-methylcarbapenems.

1988 • 27 citations

SOME 2-ACETYLTHIOPHENE DERIVATIVES AND RELATED ACETOPHENONE ANALOGS

1948 • 24 citations

SYNTHESIS OF DERIVATIVES OF 4,5-DIMETHYL-2-MERCAPTOTHIAZOLE

1949 • 24 citations

The synthesis of 2-heteroarylimidazo[1,2-a]pyridin-3-ols and related compounds

1981 • 21 citations

Benzothiazolylthio carbapenems: potent anti-MRSA agents

1995 • 20 citations

Synthesis and in vitro activity of 1.beta.-methyl C-2 quaternary heterocyclic alkylthio carbapenems

1989 • 20 citations

Synthesis and in vitro activity of C-2 quaternary heterocyclic alkylthio carbapenems.

1987 • 18 citations

Carbapenem and penem antibiotics. VII. Synthesis and antibacterial activity of 1.BETA.-methyl-2-(quaternary heteroaromatic-thiomethyl) carbapenems.

1991 • 18 citations

Unfused heterobicycles as amplifiers of phleomycin. I. Some pyridinyl- and pyrazolyl-pyrimidines, bithiazoles and thiazolylpyridines

1980 • 17 citations

Synthesis of β-imino-sulphones. Reaction of the β-imino-sulphones with carbon disulphide

1978 • 16 citations

Imidodisulfamides. 2. Substituted 1,2,3,4-tetrahydroisoquinolinylsulfonic imides as antagonists of slow-reacting substance of anaphylaxis

1982 • 15 citations

Synthesis and biological properties of 1.BETA.-methyl-carbapenems with N-methylpyrrolidinylthio group at C-2 position.

1992 • 15 citations

Heteroaryliumthio substituted carbapenem derivatives: Synthesis and in vitro activity of 1.BETA.-methyl-2-(dihydropyrrolotriazoliumthio)carbapenems.

1993 • 14 citations

Comparative in vitro activities of L-695,256, a novel carbapenem, against gram-positive bacteria

1995 • 13 citations

Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2′-ylthio)carbapenems

1994 • 12 citations

REACTIONS IN THE THIAZOLE SERIES. I. REACTIONS OF 2-CHLOROBENZOTHIAZOLES WITH THIOUREAS

1937 • 12 citations

Binding affinities of β-lactam antibodies for penicillin-binding protein 2' in methicillin-resistant Staphylococcus aureus

1995 • 11 citations

Reactions of <i>p</i>-Nitrophenylsulfenylchloride on Aromatic Heterocyclic Compounds. I

1949 • 3 citations

On the Synthesis and Antibacterial Activity of 2-Amino-4-methyl-5-thiazolyl Alkyl Sulfides and Sulfones

1952 • 3 citations