Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Vasculogenesis

1995 • 1,344 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1996 • 858 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

Differentiation of endothelium

1995 • 617 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.

1994 • 315 citations

Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.

1992 • 295 citations

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

1992 • 288 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

1992 • 242 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

Functional Analysis of the Human Endothelial Nitric Oxide Synthase Promoter

1995 • 223 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

d(TG)_n·d(CA)_nsequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription

1990 • 214 citations

Vascular endothelial cell lineage-specific promoter in transgenic mice

1995 • 196 citations

Yin-yang 1 activates the c-myc promoter.

1993 • 187 citations

Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.

1988 • 186 citations

Endothelial-specific gene expression directed by the tie gene promoter in vivo

1995 • 158 citations

Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.

1992 • 142 citations

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

1993 • 129 citations

Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.

1995 • 128 citations

Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice.

1995 • 127 citations

Endothelial-cell-specific regulation of von Willebrand factor gene expression.

1994 • 125 citations

Regulation of the Human TNF Promoter by the Transcription Factor Ets

1995 • 116 citations

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

1991 • 86 citations

High-affinity DNA-protein interactions of the cellular ETS1 protein: the determination of the ETS binding motif.

1991 • 78 citations

Characterization of the Endothelium-Specific Murine Vascular Endothelial Growth Factor Receptor-2 (Flk-1) Promoter

1996 • 77 citations

In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma.

1992 • 69 citations

Two DNA-binding proteins discriminate between the promoters of different members of the major histocompatibility complex class II multigene family.

1990 • 66 citations

Sp1, a CAAT-binding factor, and the adenovirus major late promoter transcription factor interact with functional regions of the gamma-fibrinogen promoter.

1988 • 58 citations

Yin-Yang 1 Activates the c-myc Promoter

1993 • 58 citations

E1A-induced enhancer activity of the poly(dG-dT).poly(dA-dC) element (GT element) and interactions with a GT-specific nuclear factor.

1989 • 32 citations

Endothelial-Cell-Specific Regulation of von Willebrand Factor Gene Expression

1994 • 29 citations

Two DNA-Binding Proteins Discriminate between the Promoters of Different Members of the Major Histocompatibility Complex Class II Multigene Family

1990 • 28 citations

Sp1, a CAAT-Binding Factor, and the Adenovirus Major Late Promoter Transcription Factor Interact with Functional Regions of the Gamma-Fibrinogen Promoter

1988 • 14 citations