Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1995 • 441 citations

THE PEPTIDES: Analysis, Synthesis, Biology

1981 • 274 citations

Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor.

1996 • 173 citations

Systemic analgesic activity and .delta.-opioid selectivity in [2,6-dimethyl-Tyr1, D-Pen2, D-Pen5]enkephalin

1992 • 99 citations

Development of a Model for the .delta. Opioid Receptor Pharmacophore. 1. Conformationally Restricted Tyr1 Replacements in the Cyclic .delta. Receptor Selective Tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13)

1994 • 89 citations

Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligard with high delta opioid receptor selectivity and affinity

1988 • 67 citations

Development of a Model for the .delta. Opioid Receptor Pharmacophore. 2. Conformationally Restricted Phe3 Replacements in the Cyclic .delta. Receptor Selective Tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13)

1994 • 53 citations

Conformational analysis of the .delta. receptor-selective, cyclic opioid peptide, Tyr-cyclo[D-Cys-Phe-D-Pen]OH (JOM-13). Comparison of x-ray crystallographic structures, molecular mechanics simulations, and proton NMR data

1994 • 40 citations

Development of a model for the δ-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide Tyr-c[D-Cys-Phe-D-Pen] OH with other conformationally constrained δ-receptor selective ligands

1998 • 36 citations

Development of a model for the δ-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain

1998 • 33 citations

Substitution on the Phe3 aromatic ring in cyclic .delta. opioid receptor-selective dermorphin/deltorphin tetrapeptide analogs: electronic and lipophilic requirements for receptor affinity

1992 • 24 citations