New strategy for the chemical synthesis of proteins

Application of the Principle of Hard and Soft Acids and Bases to Organic Chemistry

1967 • 880 citations

THE SYNTHESIS OF AN OCTAPEPTIDE AMIDE WITH THE HORMONAL ACTIVITY OF OXYTOCIN

1953 • 558 citations

9-Fluorenylmethoxycarbonyl function, a new base-sensitive amino-protecting group

1970 • 555 citations

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

1981 • 390 citations

Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.

1980 • 386 citations

Cleavage of N-Carbobenzoxy Groups by dry Hydrogen Bromide and Hydrogen Chloride

1952 • 378 citations

Trimethysilyl triflate in organic synthesis11Part 11 of this series. Part 10: S. Murata and R. Noyori, Tetrahedron Letters 2107 (1981).

1981 • 342 citations

Mechanisms for the removal of benzyl protecting groups in synthetic peptides by trifluoromethanesulfonic acid-trifluoroacetic acid-dimethyl sulfide

1986 • 281 citations

Acid stability of several benzylic protecting groups used in solid-phase peptide synthesis. Rearrangement of O-benzyltyrosine to 3-benzyltyrosine

1973 • 269 citations

The Synthesis of Cystine Peptides by Iodine Oxidation of S‐Trityl‐cysteine and S‐Acetamidomethyl‐cysteine Peptides

1980 • 265 citations

Total synthesis of (+-)-fumagillin

1972 • 264 citations

tert-Butoxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin, a more acid-resistant support for solid-phase peptide synthesis

1976 • 252 citations

Possible involvement of two proteins (phosphoprotein and CD9(p24)) in regulation of platelet calcium fluxes

1985 • 243 citations

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.

1984 • 239 citations

Solid phase peptide synthesis using N_α-fluorenylmethoxycarbonylamino acid pentafluorophenyl esters

1985 • 147 citations

Trimethylsilyl iodide as a peptide deblocking agent

1979 • 136 citations

Cystinpeptide aus (S‐Acetamidomethyl‐cystein)‐peptiden durch Oxydation mit Jod: Die synthese von cyclo‐<scp>L</scp>‐cystin

1971 • 124 citations

New synthetic concepts in organosulfur chemistry. I. New pathway to unsymmetrical disulfides. The thiol-induced fragmentation of sulfenyl thiocarbonates

1970 • 117 citations

Derivate von L‐Methionin‐sulfoxyd und ihre Verwendung für Peptidsynthesen

1961 • 117 citations

Conversion of alkyl carbamates into amines via treatment with trimethylsilyl iodide

1978 • 113 citations

Trifluoromethanesulphonic acid, as a deprotecting reagent in peptide chemistry

1974 • 107 citations

The isolation and sequencing of human gastric inhibitory peptide (GIP)

1984 • 98 citations

The Tertiary Butyl Group as a Blocking Agent for Hydroxyl, Sulfhydryl and Amido Functions in Peptide Synthesis

1963 • 98 citations

Further studies on the use of multi-substituted benzenesulfonyl groups for protection of the guanidino function of arginine.

1981 • 98 citations

Studies on peptides. 103. Chemical synthesis of a crystalline protein with the full enzymic activity of ribonuclease A

1981 • 86 citations

²⁹Si-chemische Verschiebungen von Trimethylsilylestern anorganischer und organischer Säuren / ²⁹Si Chemical Shifts of Trimethylsilylesters of Inorganic and Organic Acids

1972 • 82 citations

Preparation of Boc‐[S‐(3‐nitro‐2‐pyridinesulfenyl)]‐cysteine and its use for unsymmetrical disulfide bond formation

1986 • 78 citations

Eine neue, einfache Methode zur Synthese von Cystinpeptiden

1968 • 77 citations

SIDE REACTIONS IN PEPTIDE SYNTHESIS. VI.

1978 • 75 citations

The synthesis of peptides in aqueous medium, IV. A novel protecting group for cysteine

1968 • 64 citations

p-Methoxybenzenesulfonyl as a protecting group of guanidino function in peptide synthesis.

1976 • 54 citations

Studies on peptides. LXXX. NG-mesitylene-2-sulfonylarginine.

1978 • 48 citations

Silicon Tetrachloride/Sodium Iodide as a Convenient and Highly Regioselective Ether Cleaving Reagent

1982 • 47 citations

Reduction and racemization of sulfoxides by halide ions in aqueous perchloric acid

1970 • 46 citations

Deprotection of O-methyltyrosine by a ‘push–pull’ mechanism using the thioanisole–trifluoromethanesulphonic acid system. Application to the convenient synthesis of a potent N-methylenkephalin derivative

1979 • 43 citations

Sulfur-Containing Polypeptides XVII. The S-Carbomethoxysulfenyl Derivatives as a Protective Group for Cysteine

1975 • 33 citations

Synthesis of substance P via its sulfoxide by the repetitive excess mixed anhydride (REMA) method

1978 • 32 citations

Eigenschaften und Verwendbarkeit des 10, 11‐Dihydro‐5H‐dibenzo[a,d]cyclohepten‐5‐yl‐Rests (= 5‐Dibenzosuberyl‐Rests) als neue Schutzgruppe für Amine, Aminosäuren, Alkohole, Thiole und Carbonsäuren

1976 • 32 citations

The Efficient Oxidation of Thiols to Disulfides with Thallium(III) Acetate

1977 • 24 citations

Chemical synthesis of bovine pancreatic ribonuclease A

1980 • 23 citations

Studies on peptides. CXXXII. Evaluation of two .BETA.-carboxyl protecting groups of aspartic acid, cycloheptyl and cyclooctyl, for peptide synthesis.

1986 • 19 citations

Studies on peptides. CXXXIV. Evaluation of S-1-adamantylcysteine for peptide synthesis.

1986 • 12 citations

Studies on peptides. CVII. Synthesis of urotensin II.

1982 • 11 citations

Behaviour of S-substituted cysteine sulfoxide under acidolytical deprotecting conditions.

1979 • 10 citations

Synthesis of A 42 residue peptide corresponding to the entire amino acid sequence of human GIP.

1985 • 7 citations

Studies on peptides. CXLVIII Application of a new deprotecting procedure with trimethylsilyl trifluoromethanesulfonate for the syntheses of two porcine spinal cord peptides, neuromedin U-8 and neuromedin U-25.

1987 • 6 citations

Studies on peptides. CXL Synthesis of human gastrin-releasing polypeptide (hGRP).

1986 • 6 citations