Interleukin 3: Biological and clinical effects

THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO

1966 • 1,944 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

The cloning of normal “Mast” cells in tissue culture

1965 • 886 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity

1983 • 702 citations

Molecular cloning of cDNA for murine interleukin-3

1984 • 485 citations

Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity.

1983 • 465 citations

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

1984 • 365 citations

Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene

1985 • 333 citations

Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha

1988 • 331 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

1985 • 272 citations

Colony-stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures.

1987 • 270 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure

1990 • 240 citations

Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages.

1988 • 239 citations

Effects of recombinant human interleukin-3 in patients with myelodysplastic syndromes

1990 • 236 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

Human granulocyte-monocyte colony-stimulating factor and interleukin 3 stimulate monocyte cytotoxicity through a tumor necrosis factor- dependent mechanism

1988 • 221 citations

Interleukin 3-dependent mediator release in basophils triggered by C5a.

1989 • 207 citations

Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.

1987 • 206 citations

Participation of the cytokines interleukin 6, tumor necrosis factor-alpha, and interleukin 1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control.

1989 • 187 citations

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.

1990 • 163 citations

Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration.

1990 • 162 citations

Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release.

1988 • 158 citations

Heterogeneity in Human Interleukin-3 Receptors

1989 • 153 citations

Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor.

1988 • 150 citations

Human recombinant granulocyte-macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities.

1988 • 149 citations

Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia [see comments]

1990 • 145 citations

Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3.

1987 • 136 citations

Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils.

1989 • 133 citations

Recombinant human interleukin-3 and granulocyte-macrophage colony- stimulating factor show common biological effects and binding characteristics on human monocytes

1989 • 133 citations

Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines.

1987 • 129 citations

Effects of recombinant human interleukin-3 in aplastic anemia

1990 • 122 citations

Characterization of the cell surface receptor for a multi-lineage colony-stimulating factor (CSF-2 alpha).

1986 • 122 citations

Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.

1988 • 117 citations

COOH-Terminal-Modified Interleukin-3 Is Retained Intracellularly and Stimulates Autocrine Growth

1989 • 117 citations

Identification of distinct receptors for two hemopoietic growth factors (granulocyte colony-stimulating factor and multipotential colony-stimulating factor) by chemical cross-linking.

1986 • 113 citations

T cell receptor triggering induces responsiveness to interleukin 1 and interleukin 2 but does not lead to T cell proliferation.

1986 • 113 citations

Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.

1988 • 113 citations

Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia [see comments]

1990 • 112 citations

Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression

1989 • 109 citations

Growth of human hemopoietic colonies in response to recombinant gibbon interleukin 3: comparison with human recombinant granulocyte and granulocyte-macrophage colony-stimulating factor.

1987 • 108 citations

Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover.

1988 • 108 citations

Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor.

1987 • 104 citations

The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1.

1987 • 91 citations

Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3

1987 • 91 citations

Amplification of IL-2-driven T cell proliferation by recombinant human IL-3 and granulocyte-macrophage colony-stimulating factor.

1988 • 90 citations

Effects of interleukin-3 and interleukin-4 on the development of "connective tissue-type" mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3

1990 • 90 citations

Common binding structure for granulocyte macrophage colony-stimulating factor and interleukin-3 on human acute myeloid leukemia cells and monocytes

1990 • 88 citations

Production of macrophage‐, granulocyte‐, granulocyte‐macrophage‐ and multi‐colony‐stimulating factor by peripheral blood cells

1989 • 83 citations

Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro

1988 • 76 citations

Granulocyte-macrophage colony-stimulating factor (CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF

1989 • 75 citations

Purification of a multipotential colony-stimulating factor from pokeweed mitogen-stimulated mouse spleen cell conditioned medium.

1985 • 72 citations

Effects of interleukin-3 and interleukin-4 on the development of "connective tissue-type" mast cells: interleukin-3 supports their survival and interleukin-4 triggers and supports their proliferation synergistically with interleukin-3

1990 • 69 citations

Stimulation of mast cell chemotaxis by interleukin 3.

1989 • 56 citations

Hematopoietic growth factors in clinical applications

1991 • 55 citations

Human recombinant IL-3 stimulates B cell differentiation.

1989 • 54 citations

Regulation of gene expression of M-, G-, GM-, and multi-CSF in normal and malignant hematopoietic cells.

1988 • 52 citations

Effect of infection with murine recombinant retroviruses containing the v-src oncogene on interleukin 2- and interleukin 3-dependent growth states.

1987 • 47 citations

Preclinical studies on synergistic effects of IL-1, IL-3, G-CSF and GM-CSF in cynomolgus monkeys

1990 • 46 citations

Diamond-Blackfan anemia: promotion of marrow erythropoiesis in vitro by recombinant interleukin-3

1989 • 45 citations

Polypeptides controlling hematopoietic cell development and activation

1989 • 40 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells

1989 • 35 citations

Role of colony‐stimulating factors in the biology of acute myelogenous leukemia

1989 • 29 citations

Characterization of human interleukin-3 receptors on a multi-factor-dependent cell line

1989 • 27 citations

Erythropoietin prevents chemotherapy-induced anemia: Case report

1990 • 25 citations

Proliferative properties of unfractionated, purified, and single cell human progenitor populations stimulated by recombinant human interleukin-3

1990 • 24 citations

Synthesis of granulocyte colony-stimulating factor and its requirement for terminal divisions in chronic myelogenous leukemia.

1990 • 24 citations

IL-3-induced activation of protein kinases in the mast cell/megakaryocyte R6-XE.4 line.

1990 • 19 citations

Interleukin 3 : the panspecific hemopoietin

1988 • 15 citations

Generation of mature CD3+ and T cell receptor (TCR) + T cells from a leukemic analogue of the putative human stem cell by T cell conditioned medium containing IL-3, IL-2, and GM-CSF.

1988 • 14 citations

Human interleukin 3: Analysis of the gene and its role in the regulation of hematopoiesis

1990 • 9 citations

Synthesis and expression of the gene encoding human interleukin-3

1989 • 6 citations

Effects of colony-stimulating factors on leukemia progenitor cells and oncogene expression.

1988 • 2 citations