NADPH-diaphorase histochemistry provides evidence for a bilateral, somatotopically inappropriate response to unilateral hindpaw inflammation in the rat

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Expression of c‐fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation

1989 • 500 citations

Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin

1989 • 460 citations

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding

1988 • 435 citations

A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative

1993 • 428 citations

NADPH‐diaphorase: A selective histochemical marker for striatal neurons containing both somatostatin‐ and avian pancreatic polypeptide (APP)‐like immunoreactivities

1983 • 426 citations

Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms

1989 • 395 citations

Localization of NADPH‐diaphorase‐containing neurons in sensory ganglia of the rat

1991 • 330 citations

NADPH diaphorase in the spinal cord of rats

1992 • 321 citations

Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

1992 • 320 citations

Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord

1989 • 311 citations

In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia.

1988 • 292 citations

Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of n-methyl-d-aspartic acid and substance P

1991 • 281 citations

Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex

1992 • 281 citations

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

1990 • 272 citations

Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization

1988 • 268 citations

Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons

1991 • 235 citations

Changing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat

1990 • 231 citations

Nitric oxide synthetase (NOS)‐containing sympathoadrenal cholinergic neurons of the rat IML‐cell column: Evidence from histochemistry, immunohistochemistry, and retrograde labeling

1992 • 222 citations

Nadph diaphorase-positive neurons in the rat spinal cord include a subpopulation of autonomic preganglionic neurons

1992 • 204 citations

Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord

1989 • 195 citations

Nitric oxide synthase immunoreactivity in rat spinal cord

1992 • 193 citations

A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry

1988 • 191 citations

Nitric Oxide Synthases in Neuronal Cells, Macrophages and Endothelium Are NADPH Diaphorases, but Represent Only a Fraction of Total Cellular NADPH Diaphorase Activity

1993 • 188 citations

Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat

1987 • 179 citations

Long-lasting increase of nitric oxide synthase immunoreactivity, NADPH-diaphorase reaction and c-JUN co-expression in rat dorsal root ganglion neurons following sciatic nerve transection

1993 • 174 citations

Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation

1991 • 161 citations

c-fos Expression in rat lumbar spinal cord during the development of adjuvant-induced arthritis

1992 • 161 citations

Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

1992 • 151 citations

The midbrain periaqueductal gray in the rat. I. Nuclear volume, cell number, density, orientation, and regional subdivisions

1985 • 143 citations

Nitric oxide may act as a messenger between dorsal root ganglion neurones and their satellite cells

1992 • 136 citations

NADPH diaphorase activity in the posterior pituitary: relation to neuronal function

1987 • 120 citations

Neurochemical and Anatomical Changes in the Dorsal Horn of Rats with an Experimental Painful Peripheral Neuropathy

1989 • 114 citations

The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat

1990 • 114 citations

Unilateral hindpaw inflammation produces a bilateral increase in NADPH-diaphorase histochemical staining in the rat lumbar spinal cord

1992 • 110 citations

Effects of spinal kappa-opioid receptor agonists on the responsiveness of nociceptive superficial dorsal horn neurons

1991 • 110 citations

Spatial patterns of spinal cord [14C]-2-deoxyglucose metabolic activity in a rat model of painful peripheral mononeuropathy

1992 • 110 citations

Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: Cascade of transcriptional operations during nociception

1991 • 102 citations

Origin and distribution of NADPH-diaphorase-positive neurons and fibers innervating the urinary bladder of the rat

1992 • 99 citations

Nitric oxide synthase is found in some spinothalamic neurons and in neuronal processes that appose spinal neurons that express Fos induced by noxious stimulation

1993 • 93 citations

NADPH‐Diaphorase (Nitric Oxide Synthase) Staining in the Rat Supraoptic Nucleus is Activity‐Dependent: Possible Functional Implications

1992 • 90 citations

Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-d-aspartate antagonist

1991 • 84 citations

Potentiated expression of FOS protein in the rat spinal cord following bilateral noxious cutaneous stimulation

1992 • 76 citations

Functional activity mapping of the rat brainstem during formalin-induced noxious stimulation

1991 • 71 citations

Demonstration and Biochemical Characterisation of Rat Brain NADPH‐Dependent Diaphorase

1988 • 60 citations

Intrathecal induces hyperexcitability in rat dorsal horn convergent neurones

1990 • 55 citations

CGRP immunoreactivity and NADPH-diaphorase in afferent nerves of the rat penis

1992 • 52 citations

Functional activity mapping of the rat spinal cord during formalin-induced noxious stimulation

1991 • 51 citations

Distribution of NADPH-diaphorase positive cells in the rat brain

1990 • 50 citations

Partial coexistence of NADPH-diaphorase and somatostatin in the rat hypothalamic paraventricular nucleus

1992 • 46 citations

Rat brain nadph-dependent diaphorase

1988 • 44 citations

Hyperalgesia and Allodynia

1993 • 31 citations

NADPH-diaphorase reactivity in the ventral and dorsal lateral geniculate nuclei of rats

1992 • 26 citations