Kinetics of TTX‐STX Block of Sodium Channels^a

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Pharmacological Modifications of the Sodium Channels of Frog Nerve

1968 • 479 citations

The binding of saxitoxin and tetrodotoxin to excitable tissue

1977 • 369 citations

Tetrodotoxin

1965 • 315 citations

A new voltage clamp method for Ranvier nodes

1969 • 248 citations

On the mechanism of desensitization at cholinergic receptors.

1970 • 247 citations

Tetrodotoxin. VII. On the Structures of Tetrodotoxin and its Derivatives

1964 • 231 citations

Inactivation of sodium channels: second order kinetics in myelinated nerve

1977 • 201 citations

Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin

1979 • 197 citations

Sea anemone toxin:a tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling.

1976 • 184 citations

Decreased rate of sodium conductance inactivation in the node of Ranvier induced by a polypeptide toxin from sea anemone

1976 • 171 citations

Evidence for two transient sodium currents in the frog node of Ranvier.

1985 • 109 citations

The rate of action of tetrodotoxin on myelinated nerve fibres of Xenopus laevis and Rana esculenta

1973 • 106 citations

Solubilization of a specific tetrodotoxin-binding component from garfish olfactory nerve membrane

1972 • 104 citations

Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle.

1979 • 91 citations

Irreversible modification of sodium channel inactivation in toad myelinated nerve fibres by the oxidant chloramine‐T.

1984 • 87 citations

The conductance of sodium channels under conditions of reduced current at the node of Ranvier.

1980 • 86 citations

Kinetics of drug action and equilibrium results at the node of Ranvier.

1981 • 69 citations

The influence of pH on equilibrium effects of tetrodotoxin on myelinated nerve fibres of Rana esculenta.

1975 • 61 citations

The rates of saxitoxin action and of saxitoxin-tetrodotoxin interaction at the node of Ranvier

1975 • 54 citations

Distinctly different rates of benzocaine action on sodium channels of Ranvier nodes kept open by chloramine-T and veratridine

1984 • 38 citations

Behaviour of chemically modified sodium channels in frog nerve supports a three-state model of inactivation

1985 • 33 citations

Saxitoxin and procaine act independently on separate sites of the sodium channel

1976 • 30 citations

All or none block of single Na+ channels by tetrodotoxin

1985 • 27 citations

Rates of block by procaine and benzocaine and the procaine-benzocaine interaction at the node of Ranvier

1978 • 26 citations

The influence of pH on the rate of tetrodotoxin action on myelinated nerve fibres.

1975 • 25 citations

Drugs to Explore the Ionic Channels in the Axon Membrane

1974 • 18 citations

Effect of various cations and anions on the action of tetrodotoxin and saxitoxin on frog myelinated nerve fibers

1984 • 15 citations

Combined action of intraaxonal iodate and external sea anemone toxin ATX II on sodium channel inactivation of frog nerve fibres

1983 • 15 citations

The reaction between tetrodotoxin and membrane sites at the node of Ranvier: its kinetics and dependence on pH

1975 • 12 citations

Change of selectivity of sodium channels in membrane of nerve fiber treated with veratrine

1979 • 11 citations