Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

1993 • 906 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1998 • 768 citations

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

1993 • 593 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

1993 • 396 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

1996 • 331 citations

Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain

1995 • 326 citations

Sterol Regulation of Fatty Acid Synthase Promoter

1995 • 323 citations

Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene

1995 • 295 citations

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

1996 • 257 citations

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

1990 • 236 citations

Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene

1997 • 229 citations

A Direct Role for Sterol Regulatory Element Binding Protein in Activation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene

1996 • 228 citations

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

1987 • 220 citations

Sterol Regulation of 3-Hydroxy-3-Methylglutaryl-coenzyme A Synthase Gene through a Direct Interaction Between Sterol Regulatory Element Binding Protein and the Trimeric CCAAT-binding Factor/Nuclear Factor Y

1998 • 184 citations

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

1987 • 180 citations

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

1988 • 165 citations

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

1996 • 159 citations

Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection

1995 • 153 citations

Upstream Stimulatory Factor Binding to the E-box at −65 Is Required for Insulin Regulation of the Fatty Acid Synthase Promoter

1997 • 151 citations

Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences

1993 • 123 citations

Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins

1997 • 119 citations

bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes

1994 • 113 citations

NF-Y Has a Novel Role in Sterol-dependent Transcription of Two Cholesterogenic Genes

1995 • 107 citations

Multiple Sequence Elements are Involved in the Transcriptional Regulation of the Human Squalene Synthase Gene

1997 • 106 citations

Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene

1996 • 102 citations

Carbohydrate Regulation of Hepatic Gene Expression

1997 • 93 citations

Identification of a Novel Domain in the Aryl Hydrocarbon Receptor Required for DNA Binding

1996 • 89 citations

Promoter Selective Transcriptional Synergy Mediated by Sterol Regulatory Element Binding Protein and Sp1: a Critical Role for the Btd Domain of Sp1

1997 • 89 citations

Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter.

1995 • 89 citations

High affinity DNA-binding Myc analogs: Recognition by an α helix

1993 • 75 citations

Single nucleotide resolution of sterol regulatory region in promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase

1991 • 72 citations

The GCR1 Requirement for Yeast Glycolytic Gene Expression Is Suppressed by Dominant Mutations in the SGC1 Gene, Which Encodes a Novel Basic-Helix-Loop-Helix Protein

1995 • 56 citations

Transcriptional Control Mechanisms in the Regulation of Cholesterol Balance

1995 • 50 citations

The TYE7 gene of Saccharomyces cerevisiae encodes a putative bHLH‐LZ transcription factor required for Tyl‐mediated gene expression

1994 • 38 citations