Disruption of CB1 receptor signaling impairs extinction of spatial memory in mice

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

1992 • 2,910 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

1992 • 2,621 citations

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

1991 • 2,139 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

The endogenous cannabinoid system controls extinction of aversive memories

2002 • 1,689 citations

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

2001 • 1,571 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

2001 • 1,276 citations

Modulation of anxiety through blockade of anandamide hydrolysis

2002 • 1,251 citations

CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity

2003 • 1,171 citations

Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures

2004 • 1,104 citations

Control of pain initiation by endogenous cannabinoids

1998 • 1,044 citations

Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje Cells

2001 • 847 citations

Endogenous Cannabinoids Mediate Retrograde Signals from Depolarized Postsynaptic Neurons to Presynaptic Terminals

2001 • 816 citations

2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB ₁ receptor

2001 • 752 citations

Heterosynaptic LTD of Hippocampal GABAergic Synapses

2003 • 637 citations

Localization of cannabinoid receptor mRNA in rat brain

1993 • 623 citations

Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor

2002 • 601 citations

Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors

2001 • 558 citations

Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus

2001 • 543 citations

Involvement of CB1 cannabinoid receptors in emotional behaviour

2002 • 492 citations

Pain modulation by release of the endogenous cannabinoid anandamide

1999 • 482 citations

Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors

2004 • 466 citations

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB₁ Cannabinoid Receptor Knockout Mice

2000 • 399 citations

Cerebellar Depolarization-Induced Suppression of Inhibition Is Mediated by Endogenous Cannabinoids

2001 • 353 citations

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.

1996 • 352 citations

Endocannabinoids facilitate the induction of LTP in the hippocampus

2002 • 331 citations

Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

2004 • 327 citations

Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses

2002 • 296 citations

Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716

1996 • 287 citations

SR141716A is an inverse agonist at the human cannabinoid CB1 receptor

1997 • 261 citations

Evaluation of CB₁ Receptor Knockout Mice in the Morris Water Maze

2002 • 240 citations

Cannabinoids Reveal the Necessity of Hippocampal Neural Encoding for Short-Term Memory in Rats

2000 • 204 citations

Short-Term Retrograde Inhibition of GABAergic Synaptic Currents in Rat Purkinje Cells Is Mediated by Endogenous Cannabinoids

2002 • 197 citations

Enhancement of memory in cannabinoid CB1 receptor knock-out mice

1999 • 189 citations

SR 141716A Acts as an Inverse Agonist to Increase Neuronal Voltage-Dependent Ca²⁺Currents by Reversal of Tonic CB1 Cannabinoid Receptor Activity

1998 • 180 citations

The Cannabinoid CB1 Receptor Mediates Retrograde Signals for Depolarization-Induced Suppression of Inhibition in Cerebellar Purkinje Cells

2002 • 179 citations

Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

1998 • 176 citations

The cannabinoid CB 1 receptor antagonist SR141716A attenuates the memory impairment produced by ? 9 -tetrahydrocannabinol or anandamide

1998 • 176 citations

SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats

2000 • 169 citations

Differential effects of Δ 9 -THC on spatial reference and working memory in mice

2001 • 159 citations

Effect of low doses of ?9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats

2004 • 156 citations

Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors

1999 • 145 citations

Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats

1996 • 134 citations

Transgenic studies of pain

1998 • 122 citations

Endocannabinoids Mediate Rapid Retrograde Signaling At Interneuron → Pyramidal Neuron Synapses of the Neocortex

2003 • 113 citations

Learning Impairment Produced in Rats by the Cannabinoid Agonist HU 210 in a Water-Maze Task

1999 • 112 citations

SR 141716A prevents Δ9-tetrahydrocannabinol-induced spatial learning deficit in a Morris-type water maze in mice

2002 • 107 citations

SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task

2003 • 100 citations

Inhibitory effects of SR141716A on G-protein activation in rat brain

2001 • 94 citations

SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats.

1997 • 87 citations

Cannabinoids Depress Inhibitory Synaptic Inputs Received by Layer 2/3 Pyramidal Neurons of the Neocortex

2002 • 77 citations

CB ₁ Receptor Antagonist SR141716A Inhibits Ca ²⁺ -Induced Relaxation in CB ₁ Receptor-Deficient Mice

2002 • 56 citations

?9-THC-induced cognitive deficits in mice are reversed by the GABAA antagonist bicuculline

2004 • 41 citations