Channel opening of .gamma.-aminobutyric acid receptor from rat brain: molecular mechanisms of the receptor responses

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

DRUG INTERACTIONS AT THE GABA RECEPTOR-IONOPHORE COMPLEX

1982 • 696 citations

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

1975 • 637 citations

Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System

1974 • 589 citations

A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish

1969 • 414 citations

INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY NIPECOTIC ACID, VARIOUS ISOXAZOLES AND RELATED COMPOUNDS

1975 • 329 citations

Characterization and ionic basis of GABA‐induced depolarizations recorded in vitro from cat primary afferent neurones.

1978 • 321 citations

The GABA-Ergic System: A Locus of Benzodiazepine Action

1985 • 291 citations

Functional Coupling of γ-Aminobutyric Acid Receptors to Chloride Channels in Brain Membranes

1985 • 270 citations

Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding

1982 • 183 citations

Benzodiazepine Receptors in the Central Nervous System

1982 • 151 citations

GABA conductance of chick spinal cord and dorsal root ganglion neurons in cell culture.

1981 • 145 citations

Bicuculline Methochloride as a GABA Antagonist

1972 • 145 citations

gamma‐Aminobutyric‐acid‐ and pentobarbitone‐gated chloride currents in internally perfused frog sensory neurones.

1985 • 141 citations

Gamma‐aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice.

1985 • 139 citations

Biochemical and Electrophysiological Characteristics of Mammalian Gaba Receptors

1983 • 138 citations

Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique

1975 • 134 citations

Expression of functional GABA, glycine and glutamate receptors in Xenopus oocytes injected with rat brain mRNA

1984 • 134 citations

EFFECTS OF GABA ANALOGUES OF RESTRICTED CONFORMATION ON GABA TRANSPORT IN ASTROCYTES AND BRAIN CORTEX SLICES AND ON GABA RECEPTOR BINDING

1979 • 133 citations

Biochemical evidence for two classes of GABA receptors in rat brain

1979 • 104 citations

The Binding of the GAB A Agonist [³H]THIP to Rat Brain Synaptic Membranes

1982 • 102 citations

KINETICS OF ALLOSTERIC ENZYMES 9031

1974 • 99 citations

Conductance increases produced by glycine and gamma‐aminobutyric acid in lamprey interneurones.

1978 • 98 citations

γ-Aminobutyric acid-stimulated chloride permeability in crayfish muscle

1977 • 95 citations

Acetylcholine Receptor-Controlled Ion Translocation: Chemical Kinetic Investigations of the Mechanism

1983 • 94 citations

γ-Aminobutyric acid activation of36Cl-flux in rat hippocampal slices and its potentiation by barbiturates

1984 • 94 citations

Studies on the neuropharmacological activity of bicuculline and related compounds

1976 • 94 citations

Patch-clamp measurements of elementary chloride currents activated by the putative inhibitory transmitter GABA and glycine in mammalian spinal neurons.

1983 • 92 citations

Chemical instability of the GABA antagonist bicuculline under physiological conditions

1975 • 89 citations

Synthesis of chick brain GABA receptors by frog oocytes

1982 • 89 citations

gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.

1986 • 89 citations

N-methyl bicuculline, a convulsant more potent than bicuculline

1972 • 87 citations

Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes

1986 • 85 citations

Molecular mechanism of acetylcholine receptor-controlled ion translocation across cell membranes

1980 • 80 citations

Competitive interaction of β‐guanidino propionic acid and γ‐aminobutyric acid on the muscle fibre of the crayfish

1971 • 80 citations

Barbiturate and picrotoxin‐sensitive chloride efflux in rat cerebral cortical synaptoneurosomes

1984 • 80 citations

Quenched flow technique with plasma membrane vesicles: Acetylcholine receptor-mediated transmembrane ion flux

1981 • 68 citations

Werman R:The cooperativity of -aminobutyric action on the membrane of locust muscle fibers.

1973 • 65 citations

γ-Aminobutyric acid, bicuculline, and post-synaptic binding sites

1973 • 64 citations

A diazepam binding inhibitor (DBI)-like neuropeptide is detected in human brain

1986 • 61 citations

Mechanism of inactivation (desensitization) of acetylcholine receptor. Investigations by fast reaction techniques with membrane vesicles

1981 • 60 citations

Synthesis of functional chick brain GABA-benzodiazepine-barbiturate/receptor complexes in mRNA-injected Xenopus oocytes

1983 • 56 citations

An electrophysiological model of GABA-mediated neurotransmission

1981 • 47 citations

Four types of GABA receptors in crayfish leg muscles characterized by desensitization and specific antagonist

1976 • 46 citations

Patch-clamp studies of chloride channels activated by gamma-aminobutyric acid in cultured hippocampal neurones of the rat

1984 • 41 citations

Characterization of γ‐Aminobutyric Acid‐Benzodiazepine Receptor Complexes by Protection Against Inactivation by Group‐Specific Reagents

1984 • 41 citations

Acetylcholine-induced cation translocation across cell membranes and inactivation of the acetylcholine receptor: chemical kinetic measurements in the millisecond time region.

1981 • 39 citations

Specific reaction rate of acetylcholine receptor-controlled ion translocation: a comparison of measurements with membrane vesicles and with muscle cells.

1981 • 36 citations

Acetylcholine receptor-controlled ion flux in electroplax membrane vesicles: A minimal mechanism based on rate measurements in the millisecond to minute time region

1980 • 34 citations

A simple preparation of bicuculline methiodide, a water-soluble GABA antagonist

1973 • 29 citations

Two desensitization processes of GABA receptor from rat brain

1987 • 27 citations

Diazotization and Thiocyanate Differentiate Agonists from Antagonists for the High‐ and Low‐Affinity Receptors of γ‐Aminobutyric Acid

1984 • 26 citations

Chloride permeability of membrane vesicles isolated from Torpedo californica electroplax

1981 • 25 citations

GABA‐Modulin: A Synaptosomal Basic Protein that Differs from Small Myelin Basic Protein of Rat Brain

1985 • 19 citations

γ-Aminobutyric acid (GABA) mediated transmembrane chloride flux with membrane vesicles from rat brain measured by quench flow technique: Kinetic homogeneity of ion flux and receptor desensitization

1987 • 17 citations

Acetylcholine Receptor

1984 • 9 citations

Kinetic mechanism of acetylcholine receptor-controlled ion flux: Flow quench kinetic measurements of acetylcholine-induced flux in membrane vesicles

1980 • 8 citations