DNA restriction fragments associated with α1-antitrypsin indicate a single origin for deficiency allele PI Z

Statistical Methods for Research Workers

1945 • 11,140 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

The Electrophoretic α;₁-Globulin Pattern of Serum in α;₁-Antitrypsin Deficiency

1963 • 1,400 citations

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

1982 • 937 citations

Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.

1969 • 702 citations

Statistical Methods for Research Workers

1945 • 453 citations

Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa.

1984 • 415 citations

Nonrandom association of polymorphic restriction sites in the β-globin gene cluster

1982 • 408 citations

Complete sequence of the cDNA for human .alpha.1-antitrypsin and the gene for the S variant

1984 • 396 citations

ANTENATAL DIAGNOSIS OF SICKLE-CELL ANÆMIA BY D.N.A. ANALYSIS OF AMNIOTIC-FLUID CELLS

1978 • 380 citations

Pulmonary Emphysema and Proteolysis 1986

1987 • 292 citations

α1-Antitrypsin deficiency detection by direct analysis of the mutation in the gene

1983 • 277 citations

Amino acid substitution Glu→Lys in α₁‐antitrypsin PiZ

1976 • 180 citations

Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency.

1976 • 172 citations

Genes for immunoglobulin heavy chains and for α1-antitrypsin are localized to specific regions of chromosome 14q

1982 • 139 citations

Sequence homology and structural comparison between the chromosomal human α1-antitrypsin and chicken ovalbumin genes

1982 • 128 citations

Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization.

1983 • 99 citations

Association of severe rheumatoid arthritis with heterozygosity for α‐antitrypsin deficiency

1980 • 46 citations

New variants of alpha 1-antitrypsin: comparison of Pi typing techniques.

1981 • 43 citations