Genetic Analysis in Patients with Familial and Sporadic Frontotemporal Dementia: Two Tau Mutations in Only Familial Cases and No Association with Apolipoprotein ε4

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

Tau interacts with src-family non-receptor tyrosine kinases

1998 • 441 citations

High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

1999 • 419 citations

Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP‐17 and Pick's Disease

1999 • 346 citations

Tau Mutations Cause Frontotemporal Dementias

1998 • 267 citations

Segregation of a Missense Mutation in the Microtubule-Associated Protein Tau Gene with Familial Frontotemporal Dementia and Parkinsonism

1998 • 236 citations

Phenotypic variation in hereditary frontotemporal dementia with tau mutations

1999 • 222 citations

A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)

1999 • 214 citations

Inheritance of Frontotemporal Dementia

1999 • 208 citations

Tau gene mutation in familial progressive subcortical gliosis

1999 • 189 citations

Familial aggregation in frontotemporal dementia

1998 • 185 citations

A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy

1999 • 170 citations

A distinct familial presenile dementia with a novel missense mutation in the tau gene

1999 • 156 citations

The Neuropathology of a Chromosome 17-Linked Autosomal Dominant Parkinsonism and Dementia (“Pallido-Ponto-Nigral Degeneration”)

1998 • 142 citations

Frequency oftau mutations in three series of non-Alzheimer's degenerative dementia

1999 • 137 citations

From genotype to phenotype: A clinical, pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation

1999 • 134 citations

A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)

2000 • 109 citations

A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)

1999 • 68 citations

Genetic Risk Factors in Japanese Alzheimer’s Disease Patients: α1-ACT, VLDLR, and ApoE

1998 • 40 citations

Tau Mutations in Frontotemporal Dementia

1999 • 28 citations

Familial frontotemporal dementia with a P301L tau mutation in Japan

2000 • 27 citations

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

1999 • 20 citations

A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD‐Kumamoto)

2000 • 10 citations