Tumor necrosis factor (TNF) stimulates plasminogen activator inhibitor (PAI) production by endothelial cells and decreases blood fibrinolytic activity in the rat

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.

1986 • 496 citations

Synthesis of fibrinolytic activator and inhibitor by endothelial cells

1977 • 484 citations

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

1984 • 455 citations

Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.

1986 • 414 citations

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

1985 • 405 citations

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.

1986 • 401 citations

Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line.

1986 • 199 citations

Purification and characterization of human vascular plasminogen activator derived from blood vessel perfusates.

1979 • 142 citations

Cures and partial regression of murine and human tumors by recombinant human tumor necrosis factor.

1986 • 123 citations

Human endothelial cells produce a plasminogen activator inhibitor and a tissue-type plasminogen activator-inhibitor complex

1984 • 118 citations

Cytotoxic activity of tumor necrosis factor (TNF) on human cancer cells in vitro.

1981 • 113 citations

Production of a fibrinolytic inhibitor by cultured endothelial cells derived from human umbilical vein

1978 • 111 citations

Characterization of a plasminogen activator secreted by cultured bovine aortic endothelial cells

1982 • 35 citations

Effect of polymyxin B and colimycin on induction of plasminogen antiactivator by lipopolysaccharide in human endothelial cell culture

1986 • 26 citations

Plasminogen activator inhibitor induced by lipopolysaccharide injection in the rat Zymographic analysis

1987 • 4 citations