The human lymphokine-activated killer cell system

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli

1984 • 600 citations

Antigen presentation: comments on its regulation and mechanism.

1984 • 498 citations

Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells

1983 • 477 citations

ON THE PREPARATION AND PROPERTIES OF 2,4,6-TRINITROPHENYL-AMINO ACIDS AND -PEPTIDES*

1960 • 414 citations

Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.

1975 • 381 citations

Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells.

1983 • 355 citations

Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes

1984 • 350 citations

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

1984 • 310 citations

In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors.

1980 • 264 citations

Phenotypic and functional heterogeneity of human cloned natural killer cell lines

1983 • 200 citations

The reaction of 2,4,6-trinitrobenzenesulphonic acid with amino acids, peptides and proteins

1968 • 158 citations

Lymphokine‐Driven “Differentiation” of Cytotoxic T‐Cell Clones into Cells with NK‐Like Specificity: Correlations with Display of Membrane Macromolecules

1983 • 158 citations

Studies on cytotoxicity generated in human mixed lymphocyte cultures. I. Time course and target spectrum of several distinct concomitant cytotoxic activities.

1978 • 149 citations

Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes.

1980 • 141 citations

Studies on cytotoxicity generated in human mixed lymphocyte cultures. II. Anti-K562 effectors are distinct from allospecific CTL and can be generated from NK-depleted T cells.

1979 • 124 citations

Characterization of HNK-1+ (Leu-7) human lymphocytes. II. Distinguishing phenotypic and functional properties of natural killer cells from activated NK-like cells.

1982 • 111 citations

Disappearance of the NK effect after explantation of lymphocytes and generation of similar nonspecific cytotoxicity correlated to the level of blastogenesis in activated cultures.

1980 • 109 citations

H‐2 Restricted Cytolytic and Noncytolytic T Cell Clones: Isolation, Specificity and Functional Analysis

1981 • 95 citations

Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens.

1981 • 94 citations

Studies on Cytotoxicity Generated in Human Mixed Lymphocyte Cultures

1978 • 93 citations

Generation of cytotoxic T lymphocytes to autologous human leukaemia cells by sensitisation to pooled allogeneic normal cells

1978 • 92 citations

Induction of cytotoxic activity in human lymphocytes against autologous and allogeneic melanoma cellsin vitro by culture with interleukin 2

1981 • 88 citations

Studies on Cytotoxicity Generated in Human Mixed Lymphocyte Cultures

1979 • 78 citations

In vitro augmentation of natural killing activity by OK-432

1981 • 75 citations

Generation of nonspecific murine cytotoxic T cells in vitro by purified human interleukin 2

1984 • 60 citations

In vitro generation of human activated lymphocyte killer cells: separate precursors and modes of generation of NK-like cells and "anomalous" killer cells.

1984 • 57 citations

Development of large granular lymphocytes with anomalous, nonspecific cytotoxicity in clones derived from Ly-2+ T cells.

1983 • 53 citations

Lysis of syngeneic solid tumor cells by alloantigen stimulated mouse T and non-T cells.

1980 • 52 citations

Human T-Cell Growth Factor: Purification, Biochemical Characterization, and Interaction with a Cellular Receptor

1982 • 50 citations

Natural and activated cytotoxic lymphocytes which act on autologous and allogeneic tumor cells

1981 • 45 citations

Induction of Natural Killer Cell Activity and Allocytotoxicity in Human Peripheral Blood Lymphocytes after Mixed Lymphocyte Culture

1981 • 45 citations

Characterization of the T lymphocyte colony-forming cells and evidence for the acquisition of T cell markers in the absence of the thymic microenvironment in man.

1981 • 40 citations

In vitro reeducated T helper cells from sarcoma-bearing mice inhibit sarcoma growth in vivo.

1984 • 39 citations

The requirement for DNA synthesis and gene expression in the generation of cytotoxicity in vitro.

1975 • 37 citations

Activation of nonspecific killer cells by interleukin 2-containing supernatants.

1983 • 37 citations

Growth at limiting dilution of human T cell colonies from T cell-depleted peripheral blood leukocytes.

1983 • 35 citations

Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self-H-2 specificity and bearing T cell markers.

1983 • 35 citations

Dissociation of differentiation and proliferation in the primary induction of cytolytic T lymphocytes by alloantigens.

1980 • 31 citations

In vitro growth of cytotoxic human lymphocytes

1982 • 30 citations

Alloantigen-induced cytotoxicity against syngeneic tumor cells: analysis at the clonal level.

1984 • 26 citations

Surface carbohydrates of aged erythrocytes

1978 • 26 citations

Differentiation of NK-like cells from OKT3-, OKT11+, and OKM1+ small resting lymphocytes by culture with autologous T cell blasts and lymphokine.

1984 • 22 citations

A novel type of human T cell clone with highly potent natural killer-like cytotoxicity divorced from large granular lymphocyte morphology.

1984 • 22 citations

A shared antigenic specificity of human large granular lymphocytes and precursors of NK-like and allospecific cytotoxic effector cells.

1984 • 20 citations

Generation of cytotoxic T lymphocytes against modified self in the absence of antigen by interleukin 2-containing preparations

1983 • 18 citations

Natural Killer‐like Cytotoxicity of Human T‐Cell Clones against Various Target Cells

1983 • 12 citations

HLA-DR antigens induce proliferation and cytotoxicity of T cells against haptenated (TNP and FITC) self structures

1981 • 12 citations

Anomalous killer cells: Thymus cell dependency, precursor frequency, and response to immunosuppressive therapy

1982 • 5 citations

Cloned human T-cell lines with allospecific or natural killer-like cytotoxicity

1982 • 2 citations