Purification and characterization of defensins from cystic fibrosis sputum

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

1993 • 986 citations

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

1989 • 695 citations

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

1996 • 551 citations

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

1990 • 540 citations

Monocyte-chemotactic activity of defensins from human neutrophils.

1989 • 486 citations

Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis.

1993 • 209 citations

Defensins are mitogenic for epithelial cells and fibroblasts

1993 • 199 citations

Direct Cytotoxicity of Polymorphonuclear Leukocyte Granule Proteins to Human Lung-derived Cells and Endothelial Cells

1990 • 162 citations

Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane.

1991 • 143 citations

Neutrophil defensins: Purification, characterization, and antimicrobial testing

1994 • 136 citations

Human neutrophil defensin and serpins form complexes and inactivate each other.

1995 • 130 citations

Levels of Free Granulocyte Elastase in Bronchial Secretions from Patients with Cystic Fibrosis: Effect of Antimicrobial Treatment Against Pseudomonas aeruginosa

1986 • 124 citations

NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1

1992 • 117 citations

An Immortalized Cystic Fibrosis Tracheal Epithelial Cell Line Homozygous for the ΔF508 CFTR Mutation

1993 • 115 citations

Activated α₂-Macroglobulin Is a Principal Defensin-binding Protein

1991 • 105 citations

Establishment of Radioimmunoassay for Human Neutrophil Peptides and Their Increases in Plasma and Neutrophil in Infection

1993 • 72 citations

Inheritance of Unequal Numbers of the Genes Encoding the Human Neutrophil Defensins HP-1 and HP-3

1995 • 68 citations

An enzyme immunoassay for human defensins

1991 • 60 citations

Sputum sol-phase proteins and elastase activity in patients with cystic fibrosis.

1984 • 47 citations

Defensins Reduce the Barrier Integrity of a Cultured Epithelial Monolayer without Cytotoxicity

1993 • 31 citations

Defensins: ancient but potentially dangerous weapons in the armoury.

1992 • 4 citations