Autism spectrum disorders: developmental disconnection syndromes

DISCONNEXION SYNDROMES IN ANIMALS AND MAN

1965 • 3,304 citations

Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification

1979 • 2,523 citations

Autism as a strongly genetic disorder: evidence from a British twin study

1995 • 2,442 citations

Critical period plasticity in local cortical circuits

2005 • 2,144 citations

DISCONNEXION SYNDROMES IN ANIMALS AND MAN

1965 • 1,787 citations

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism

2003 • 1,785 citations

Sensitive Periods in the Development of the Brain and Behavior

2004 • 1,607 citations

Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity

2004 • 1,545 citations

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

2006 • 1,507 citations

Intellectual ability and cortical development in children and adolescents

2006 • 1,497 citations

INFANTILE AUTISM: A GENETIC STUDY OF 21 TWIN PAIRS

1977 • 1,333 citations

Autistic Traits in the General Population

2003 • 1,203 citations

A Case‐Control Family History Study of Autism

1994 • 1,076 citations

A clinicopathological study of autism

1998 • 1,061 citations

Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum Morphometry

2006 • 1,051 citations

Time to give up on a single explanation for autism

2006 • 977 citations

Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection

2005 • 926 citations

Minicolumnar pathology in autism

2002 • 834 citations

Pervasive Developmental Disorders in Preschool Children: Confirmation of High Prevalence

2005 • 791 citations

A Twin Study of Autism in Denmark, Finland, Iceland, Norway and Sweden

1989 • 782 citations

X-Linked Mental Retardation and Autism Are Associated with a Mutation in the NLGN4 Gene, a Member of the Neuroligin Family

2004 • 752 citations

Postnatal Neurodevelopmental Disorders: Meeting at the Synapse?

2003 • 671 citations

Localization of white matter volume increase in autism and developmental language disorder

2004 • 653 citations

Functional connectivity in an fMRI working memory task in high-functioning autism

2004 • 608 citations

Recessive Symptomatic Focal Epilepsy and Mutant Contactin-Associated Protein-like 2

2006 • 602 citations

Searching for ways out of the autism maze: genetic, epigenetic and environmental clues

2006 • 573 citations

Neuropsychologic functioning in autism: Profile of a complex information processing disorder

1997 • 551 citations

Sentence comprehension in autism: thinking in pictures with decreased functional connectivity

2006 • 509 citations

Genetic Heterogeneity Between the Three Components of the Autism Spectrum: A Twin Study

2006 • 509 citations

Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy

2005 • 499 citations

Minicolumnar abnormalities in autism

2006 • 497 citations

Neurogenesis in adult primate neocortex: an evaluation of the evidence

2002 • 480 citations

Defining the broader phenotype of autism: Genetic, brain, and behavioral perspectives

2002 • 475 citations

Macrocephaly in Children and Adults With Autism

1997 • 443 citations

Localized enlargement of the frontal cortex in early autism

2005 • 437 citations

Annotation: The neural basis of social impairments in autism: the role of the dorsal medial‐frontal cortex and anterior cingulate system

2003 • 421 citations

A genetic variant that disrupts MET transcription is associated with autism

2006 • 399 citations

Stereological Analysis of Amygdala Neuron Number in Autism

2006 • 398 citations

Genetic influences and infantile autism

1977 • 398 citations

Structural and functional maturation of the developing primate brain

2003 • 396 citations

Head circumference and height in autism: A study by the collaborative program of excellence in autism

2006 • 365 citations

Psychiatric Disorder and the Broad Autism Phenotype: Evidence From a Family Study of Multiple-Incidence Autism Families

1999 • 363 citations

Fine Mapping of Autistic Disorder to Chromosome 15q11-q13 by Use of Phenotypic Subtypes

2003 • 345 citations

Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder

2001 • 340 citations

Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type-Specific Deficits, Epilepsy, and Behavioral Dysfunction

2003 • 331 citations

Microcephaly and macrocephaly in autism.

1999 • 324 citations

Hepatocyte Growth Factor/Scatter Factor Is a Motogen for Interneurons Migrating from the Ventral to Dorsal Telencephalon

2001 • 317 citations

Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness

2002 • 285 citations

Evidence for a Language Quantitative Trait Locus on Chromosome 7q in Multiplex Autism Families

2002 • 274 citations

Subplate Neurons Regulate Maturation of Cortical Inhibition and Outcome of Ocular Dominance Plasticity

2006 • 242 citations

An MRI Study of Increased Cortical Thickness in Autism

2006 • 236 citations

The development of cortical connections

2006 • 213 citations

Neuropsychologic Functioning in Children with Autism: Further Evidence for Disordered Complex Information-Processing

2006 • 208 citations

Analysis of the RELN gene as a genetic risk factor for autism

2004 • 198 citations

Autism at the beginning: Microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism

2005 • 194 citations

Columnar Architecture Sculpted by GABA Circuits in Developing Cat Visual Cortex

2004 • 192 citations

Cortical Gray and White Brain Tissue Volume in Adolescents and Adults with Autism

2005 • 184 citations

Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

2006 • 174 citations

Understanding Autism

2006 • 170 citations

Reduced minicolumns in the frontal cortex of patients with autism

2006 • 146 citations

A Century of Progress in Corticoneurogenesis: From Silver Impregnation to Genetic Engineering

2006 • 144 citations

Is autism a disconnection disorder?

2004 • 138 citations

Taking the Measure of Diversity: Comparative Alternatives to the Model-Animal Paradigm in Cortical Neuroscience

2000 • 133 citations

A Quantitative Trait Locus Analysis of Social Responsiveness in Multiplex Autism Families

2007 • 133 citations

Cognitive Deficits in Parents from Multiple‐incidence Autism Families

1997 • 131 citations

Disruption of Interneuron Development

2005 • 126 citations

Association of Reelin gene polymorphisms with autism

2005 • 124 citations

An Examination of Social Typologies in Autism

1989 • 106 citations

Histological and Magnetic Resonance Imaging Assessment of Cortical Layering and Thickness in Autism Spectrum Disorders

2006 • 101 citations

HGF regulates the development of cortical pyramidal dendrites

2004 • 88 citations

Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development

2002 • 86 citations

Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network

2004 • 85 citations

Autism and Autistic Behavior in Joubert Syndrome

1999 • 82 citations

An MRI Study of Increased Cortical Thickness in Autism

2006 • 68 citations

The genetics of autism

2004 • 64 citations

Region‐ and age‐specific deficits in γ‐aminobutyric acidergic neuron development in the telencephalon of the uPAR^–/– mouse

2005 • 54 citations

Stratification based on language‐related endophenotypes in autism: Attempt to replicate reported linkage

2006 • 46 citations

The Discipline of Neurobehavioral Development: The Emerging Interface of Processes That Build Circuits and Skills

2006 • 43 citations

A Quantitative Trait Locus Analysis of Social Responsiveness in Multiplex Autism Families

2007 • 38 citations

Finding Genes in Spite of Heterogeneity

2006 • 5 citations