Effector phenotype and immunologic specificity of T cell-mediated adoptive therapy for a murine tumor that lacks intrinsic immunogenicity

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Cancer Research: Some Forward Steps

1965 • 733 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

STUDIES ON THE IMMUNOLOGICAL RESPONSE TO FOREIGN TUMOR TRANSPLANTS IN THE MOUSE

1955 • 317 citations

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.

1981 • 317 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo.

1987 • 292 citations

In Vivo Antitumor Activity of Tumor-Infiltrating Lymphocytes Expanded in Recombinant Interleukin-2

1987 • 250 citations

Passive Immunotherapy of Cancer in Animals and Man

1977 • 245 citations

Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2.

1987 • 211 citations

TREATMENT OF PRIMARY FIBROSARCOMA IN THE RAT WITH IMMUNE LYMPHOCYTES

1964 • 149 citations

The Choice of Animal Tumors for Experimental Studies of Cancer Therapy

1978 • 143 citations

Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes.

1980 • 141 citations

Adoptive immunotherapy of newly induced murine sarcomas.

1985 • 137 citations

Specific adoptive therapy of established leukemia with syngeneic lymphocytes sequentially immunized in vivo and in vitro and nonspecifically expanded by culture with Interleukin 2.

1981 • 130 citations

Generation from tumor-bearing mice of lymphocytes with in vivo therapeutic efficacy.

1987 • 129 citations

Interleukin 2 administered in vivo induces the growth of cultured T cells in vivo.

1984 • 100 citations

Generation of therapeutic T lymphocytes from tumor-bearing mice by in vitro sensitization. Culture requirements and characterization of immunologic specificity.

1988 • 99 citations

Therapy of murine leukemia with cyclophosphamide and immune Lyt-2+ cells: cytolytic T cells can mediate eradication of disseminated leukemia.

1986 • 95 citations

Inhibition of established transplants of chemically induced sarcomas in syngeneic mice by lymphocytes from immunized donors

1972 • 95 citations

In vitro sensitization and expansion with viable tumor cells and interleukin 2 in the generation of specific therapeutic effector cells.

1986 • 89 citations

Lymphocytes generated by in vivo priming and in vitro sensitization demonstrate therapeutic efficacy against a murine tumor that lacks apparent immunogenicity.

1989 • 89 citations

Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha.

1988 • 86 citations

Adoptive immunotherapy of established syngeneic solid tumors: role of T lymphoid subpopulations.

1984 • 80 citations

Adoptive immunotherapy of microscopic and advanced visceral metastases with in vitro sensitized lymphoid cells from mice bearing progressive tumors.

1988 • 64 citations

In Vivo Elimination by Specific Effector Cells of an Established Syngeneic Rat Moloney Virus-Induced Sarcoma

1979 • 62 citations

Regression of Established Intradermal Tumors and Lymph Node Metastases in Guinea Pigs After Systemic Transfer of Immune Lymphoid Cells

1977 • 60 citations

Immunological approaches to cancer therapeutics

1983 • 55 citations

Tumor neutralization, immunotherapy, and chemoimmmunotherapy of a Friend leukemia with cells secondarily sensitized in vitro.

1977 • 46 citations

The questionable immunogenicity of certain neoplasms

1977 • 45 citations

Immunological approaches to cancer therapeutics

1982 • 33 citations

Tumor Neutralization, Immunotherapy, and Chemoimmunotherapy of a Friend Leukemia with Cells Secondarily Sensitized in vitro

1977 • 32 citations

In vitro differentiation of T-cells capable of mediating the regression of established syngeneic tumors in mice.

1987 • 32 citations

Cellular interactions and the role of interleukin 2 in the expression and induction of immunity against a syngeneic murine sarcoma.

1987 • 31 citations

Cellular basis of immunologic interactions in adoptive T cell therapy of established metastases from a syngeneic murine sarcoma.

1988 • 25 citations

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