Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-Early stage gastric carcinoma

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

1997 • 1,055 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1997 • 929 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

1997 • 861 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.

1997 • 428 citations

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas.

1997 • 354 citations

Prognostic factors in gastric carcinoma. Results of the German gastric carcinoma study 1992

1993 • 347 citations

Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the Japanese literature

1993 • 333 citations

Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma.

1998 • 329 citations

Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.

1997 • 326 citations

Cyclins, Cyclin-Dependent Kinases and Cdk Inhibitors: Implications in Cell Cycle Control and Cancer

1995 • 314 citations

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

1997 • 305 citations

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

1994 • 298 citations

Formation of p27-CDK complexes during the human mitotic cell cycle.

1996 • 247 citations

p27Kip1 overexpression causes apoptotic death of mammalian cells

1997 • 228 citations

The Most Important Prognostic Factors for Gastric Cancer Patients: A Study Using Univariate and Multivariate Analyses

1987 • 226 citations

The ubiquitin-proteasome pathway in cancer

1998 • 223 citations

Retinoblastoma protein family in cell cycle and cancer: A review

1996 • 198 citations

Apoptosis in breast cancer as related to histopathological characteristics and prognosis

1994 • 196 citations

The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

1995 • 182 citations

Protective Role of p21^Waf1/Cip1 against Prostaglandin A₂-Mediated Apoptosis of Human Colorectal Carcinoma Cells

1996 • 160 citations

Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes.

1994 • 140 citations

Reduced Expression of Cyclin–dependent Kinase Inhibitor p27^Kipl Is Associated with Advanced Stage and Invasiveness of Gastric Carcinomas

1997 • 132 citations

Inhibition of G₁ Cyclin-Dependent Kinase Activity during Growth Arrest of Human Breast Carcinoma Cells by Prostaglandin A₂

1996 • 113 citations

Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival

1996 • 109 citations

Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma.

1997 • 97 citations

Mode of Recurrence after Gastric Cancer Surgery

1994 • 52 citations

Prediction of survival time after curative surgery for advanced gastric cancer.

1992 • 27 citations

Targeting Ubiquitin-Mediated Degradation for Proliferation Inhibitors

1996 • 13 citations

Proposal of a risk score for recurrence in patients with curatively resected gastric cancer

1993 • 11 citations

Evaluation of limited resection of the lung for treatment of lung cancer

1982 • 2 citations