Genetics, Ageing and Dementia

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Observations on the brains of demented old people

1970 • 2,066 citations

The inheritance of liability to certain diseases, estimated from the incidence among relatives

1965 • 1,618 citations

MULTI-INFARCT DEMENTIA A CAUSE OF MENTAL DETERIORATION IN THE ELDERLY

1974 • 1,079 citations

Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes.

1967 • 1,002 citations

Greenfield's neuropathology

1976 • 961 citations

Handbook of the Biology of Aging

1978 • 871 citations

Alzheimer's Disease: Senile Dementia and Related Disorders

1979 • 801 citations

Xeroderma Pigmentosum

1974 • 755 citations

Molecular Mechanisms for Repair of DNA

1975 • 676 citations

Observations on the brains of non-demented old people

1968 • 656 citations

Old Age Mental Disorders in Newcastle upon Tyne

1964 • 568 citations

Prevalence and Malignancy of Alzheimer Disease

1976 • 515 citations

Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations

1980 • 454 citations

Dementia of the Alzheimer Type

1981 • 451 citations

Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

1979 • 445 citations

Cell loss in the locus coeruleus in senile dementia of Alzheimer type

1981 • 443 citations

The genetics of mental disorders

1971 • 419 citations

Genetics of Coronary Artery Disease

2016 • 332 citations

ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?

1979 • 326 citations

Genetics of Common Disorders

1969 • 297 citations

Down syndrome—a disruption of homeostasis

1983 • 280 citations

GENETICS OF COMMON DISORDERS

1969 • 280 citations

Change of Human Chromosome Count Distributions with Age: Evidence for a Sex Difference

1963 • 273 citations

Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease

1981 • 266 citations

Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia

1982 • 261 citations

Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation.

1978 • 257 citations

ATAXIA TELANGIECTASIA: An Inherited Human Disorder Involving Hypersensitivity to Ionizing Radiation and Related DNA-Damaging Chemicals

1979 • 254 citations

Distribution of Human Chromosome Counts in Relation to Age

1961 • 242 citations

THE GENETIC FACTOR IN DUPUYTREN'S DISEASE

1963 • 239 citations

Down's Anomaly

1966 • 238 citations

Presenile dementia in Down's syndrome

1974 • 219 citations

HUMAN DISORDERS SHOWING INCREASED SENSITIVITY TO THE INDUCTION OF GENETIC DAMAGE

1978 • 212 citations

Metabolism of Oxygen Derivatives in Down's Syndrome*

1982 • 199 citations

Essential tremor: a clinical and genetic population study.

1960 • 193 citations

Relationship between plaques, tangles, and dementia in Down syndrome

1980 • 189 citations

STUDIES ON BRAIN BIOPSIES OF PATIENTS WITH HUNTINGTONʼS CHOREA

1974 • 185 citations

The Epidemiology of Dementia.

1981 • 184 citations

Neuropathology of Organic Brain Syndromes Associated with Aging

1972 • 182 citations

Intrinsic Mutagenesis: A Genetic Approach to Ageing.

1975 • 177 citations

Trisomie 21 et superoxyde dismutase-1 (IPO-A)

1976 • 175 citations

Evidence for and against the transmissibility of Alzheimer disease

1980 • 166 citations

Morbus Alzheimer and Morbus Pick: A Genetic, Clinical and Patho-anatomical Study

1953 • 162 citations

Senile Dementia. A Clinical, Sociomedical and Genetic Study.

1964 • 161 citations

Mental illness and hospital usage in the elderly: A random sample followed up

1970 • 156 citations

Precocious aging and dementia in patients with Down's syndrome.

1978 • 154 citations

GERONTO‐PSYCHIATRIC PERIOD‐PREVALENCE INVESTIGATION IN A GEOGRAPHICALLY DELIMITED POPULATION

1962 • 151 citations

A Population Study of Senile and Arteriosclerotic Psychoses

1969 • 139 citations

The Aging Brain and Senile Dementia

1977 • 135 citations

Down's syndrome

1974 • 134 citations

Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-linked Phenotypes.

1975 • 132 citations

Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core.

1981 • 130 citations

Intrinsic mutagenesis

1974 • 122 citations

RELATIONSHIP OF AMYLOID TO AGING

1969 • 120 citations

Ageing and Immunological Function in Man

1972 • 118 citations

The Genetics of Alzheimer's Disease

1977 • 116 citations

The Extrapyramidal Disorder of Alzheimer’s Disease

1974 • 115 citations

Clinical Heterogeneity in Senile Dementia

1969 • 112 citations

A Study of Familial Factors in Alzheimer's Disease

1982 • 101 citations

Partial trisomy 21

1977 • 99 citations

The Genetics of Mental Disorders

1972 • 99 citations

MENTAL ILLNESS AND THE AGEING BRAIN

1963 • 98 citations

Down's Syndrome, Aging, and Alzheimer's Disease: A Clinical Review*

1982 • 96 citations

COMPARATIVE NEUROPATHOLOGY OF AGEING: STUDIES ON THE BRAINS OF 47 SPECIES OF VERTEBRATES

1971 • 95 citations

PARKINSON'S DISEASE

1973 • 95 citations

Biological Mechanisms of Aging

1963 • 95 citations

Alzheimer Degeneration in Down Syndrome

1975 • 93 citations

THE QUANTITATIVE ASSESSMENT OF LIPOFUSCIN PIGMENT, CYTOPLASMIC RNA AND NUCLEOLAR VOLUME IN SENILE DEMENTIA

1978 • 88 citations

Alzheimer's Disease and Related Conditions.

1971 • 87 citations

The Dementia of Down's Syndrome and its Relevance to Aetiological Studies of Alzheimer's Disease

1982 • 85 citations

An inquiry concerning growth, disease and ageing

1968 • 83 citations

Alzheimer's Disease in Down's Syndrome: Visual Retention Deficits

1974 • 79 citations

Histopathologische Untersuchungen über Entstehung und Wesen der senilen Plaques

1929 • 77 citations

Familial Down syndrome due to t(10;21) translocation: evidence that the Down phenotype is related to trisomy of a specific segment of chromosome 21.

1975 • 77 citations

Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in fibroblasts from patients with Huntington disease, familial dysautonomia, and other primary neuronal degenerations.

1981 • 68 citations

Giant cell arteritis and arteriolitis associated with amyloid angiopathy in an elderly mongol

1974 • 68 citations

Epidemiology of senile dementia.

1978 • 67 citations

Age-associated structural alterations in senescent mouse brain DNA

1977 • 67 citations

Neuronal Lipofuscin Accumulation in Ageing and Alzheimer Dementia: A Pathogenic Mechanism?

1982 • 67 citations

Significance of Repair of Human DNA: Evidence From Studies of Xeroderma Pigmentosum

1978 • 66 citations

Evidence for a correlation between late replication and autosomal gene inactivation in a familial translocation t(X;21)

1979 • 66 citations

Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging

1978 • 62 citations

TOPOGRAPHY OF NEUROFIBRILLARY TANGLES AND GRANULOVACUOLES IN HIPPOCAMPI OF PATIENTS WITH DOWN'S SYNDROME: QUANTITATIVE COMPARISON WITH NORMAL AGEING AND ALZHEIMER'S DISEASE

1981 • 62 citations

The Pathologic Physiology of Dementia

1978 • 61 citations

Organic Mental Syndrome and Confusional States in Parkinson's Disease

1981 • 61 citations

Increased aneuploidy in Alzheimer disease

1979 • 60 citations

Cytogenetic studies of familial and sporadic Alzheimer disease

1981 • 57 citations

The repair of X-ray induced chromosomal damage in trisomy 2-and normal diploid lymphocytes.

1977 • 56 citations

Exogenous DNA polymerase-catalysed incorporation of deoxyribonucleotide monophosphates in nuclei of fixed mouse-brain cells *1Changes associated with age and X-irradiation

1971 • 55 citations

THE EEG AND INCIDENCE OF EPILEPSY IN DOWN'S SYNDROME

1979 • 51 citations

Neurological epidemiology : principles and clinical applications

1978 • 49 citations

ELECTRON MICROSCOPICAL STUDY OF THE BRAIN IN DOWN'S SYNDROME

1972 • 48 citations

Chromosomes in Senile Dementia

1968 • 48 citations

Psychiatric services and mental illness in Iceland. Incidence study (1966-1967) with 6-7 year follow-up.

1977 • 45 citations

Pathogenesis of Neuritic (Senile) and Amyloid Plaque Formation

1982 • 44 citations

Moderate Down's syndrome in three siblings having partial trisomy 21q22.2?qter and therefore no SOD-1 excess

1982 • 43 citations

A statistical and genetical study of diabetes: II. Heritability of liability

1972 • 43 citations

X‐ray‐induced chromosome aberrations in down lymphocytes: An explanation of their increased sensitivity

1981 • 41 citations

Effect of age on the induction of autoantibodies.

1981 • 40 citations

Chromosome examinations in aged twins.

1970 • 40 citations

Mental Illness and The Ageing Brain

1963 • 38 citations

Partial trisomies of chromosome 21 in man. Two new observations due to translocations 19;21 and 4;21

1977 • 37 citations

Cockayne's syndrome: case report

1971 • 36 citations

Life span changes in the averaged evoked responses of Down's syndrome and nonretarded persons.

1978 • 35 citations

Mortality of the Aged with Chronic Brain Syndrome

1973 • 34 citations

Chromosomes in Senile, Presenile, and Arteriosclerotic Dementia

1970 • 34 citations

Epidemiological Aspects of Organic Brain Disease in the Aged

1972 • 34 citations

The neuronal ceroid-lipofuscinoses--Batten-Vogt syndrome: a model for human aging?

1971 • 34 citations

Organic brain syndrome and chromosome loss in aged twins.

1971 • 32 citations

Genetics of Longevity in Man

1978 • 32 citations

Stroop Color-Word Test, Non-Psychotic Organic Brain Syndrome, and Chromosome Loss in Aged Twins

1971 • 32 citations

Mendelian inheritance or transmissible agent? The lesson Kuru and the Australia antigen.

1977 • 31 citations

Biological Mechanisms of Aging

1966 • 31 citations

Immunological Studies of Down's Syndrome and Alzheimer's Disease*

1982 • 31 citations

A statistical and genetical study of diabetes

1973 • 31 citations

The Genetics of Aging

1978 • 31 citations

Senile Plaques and Neurofibrillary Tangles of the Alzheimer Type in Nondemented Individuals at Presenile Age

1982 • 30 citations

Clinical Aspects of Down’s Syndrome from Infancy to Adult Life

1981 • 29 citations

Bleomycin-induced chromosomal aberrations in Down's syndrome lymphocytes

1982 • 29 citations

Neurological and Sensory Disorders in the Elderly

1976 • 29 citations

Control of DNA Repair Linked to Neuroblastoma Differentiation

1976 • 28 citations

Hypertension, Multi-Infarct Dementia and Alzheimer's Disease

1983 • 27 citations

Down syndrome due to partial trisomy 21q

1977 • 27 citations

Genetic components and intellectual functioning during senescence: A 20-year study of aging twins

1972 • 26 citations

Histochemical studies on the lipo-pigments in the nerve cells. A comparison with lipofuscin and ceroid pigment

1968 • 26 citations

Neurotransmitters of the Cerebral Cortex in Senile Dementia of Alzheimer Type

1982 • 23 citations

Partial trisomy 20 (20q13) and partial trisomy 21 (21pter leads to 21q21.3).

1977 • 23 citations

Chromosomal Deviations in Alzheimer’s Disease Compared to those in Senescence and Senile Dementia

1973 • 23 citations

Aetiology and natural history of Parkinson's disease.

1978 • 21 citations

PREMATURE SENILITY IN DOWN'S SYNDROME

1970 • 21 citations

Ageing in Differentiated Cells

1974 • 20 citations

Analysis of family history data for evidence of non-Mendelian inheritance resulting from vertical transmission.

1977 • 19 citations

Cerebral Atrophy in Parkinson Syndrome

1982 • 19 citations

Down's syndrome phenotype and autosomal gene inactivation in a child with presumed (X;21) de novo translocation.

1982 • 18 citations

Somatic Mutations and Aging

1978 • 17 citations

Partial trisomy and monosomy 21 in an infant with an unusual de novo 21/21 translocation.

1980 • 17 citations

Mutagen hypersensitivity in Friedreich's ataxia

1983 • 17 citations

Chromosomes and Mental Status

1974 • 16 citations

A post mortem study of the main cerebral arteries with special reference to the cause of strokes.

1961 • 16 citations

ANEUPLOIDY IN CULTURED HUMAN LYMPHOCYTES: II. A COMPARISON BETWEEN SENESCENCE AND DEMENTIA

1981 • 16 citations

Chromosome Aneuploidy in Alzheimer’s Disease

1982 • 13 citations

On the Distribution of Senile Changes in the Spinal Cord

1978 • 12 citations

Partial trisomy 21

1980 • 11 citations

Aging Changes in Relation to Diseases of the Nervous System

1975 • 11 citations

Apparent G-monosomy, G-deletion, and incomplete Down's syndrome in a single family.

1972 • 10 citations

ALZHEIMER'S DISEASE IN SIBLINGS

1970 • 10 citations

DEMENTIA AS AN ACCELERATED AGEING OF THE NERVOUS SYSTEM: SOME PSYCHOLOGICAL AND METHODOLOGICAL CONSIDERATIONS

1974 • 8 citations

The response of cells from patients with Huntington's chorea to mutagen‐induced chromosome damage

1982 • 8 citations

Recent progress in the psychiatry of old age and its bearing on certain problems of psychiatry in earlier life.

1972 • 8 citations

Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core

1982 • 6 citations

Lists of Genes Affecting DNA Metabolism in Escherichia coli

1975 • 6 citations

Neurochemistry of Alzheimer’s Disease: An Update

1982 • 5 citations

ATAXIA‐TELANGIECTASIA

1960 • 5 citations

Neurotransmitter and Neuropeptide Systems in Alzheimer-Type Dementia

1982 • 4 citations

A behavioral-chromosome relationship in the elderly: A critical review of a biobehavioral hypothesis

1976 • 1 citations