Molecular biology of malaria parasites

Genomic sequencing.

1984 • 8,343 citations

Molecular Cell Biology

1986 • 5,808 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Slipped-strand mispairing: a major mechanism for DNA sequence evolution.

1987 • 2,272 citations

Kinetics of renaturation of DNA

1968 • 1,446 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

Evolution of Repeated DNA Sequences by Unequal Crossover

1976 • 1,208 citations

DNA bending at adenine · thymine tracts

1986 • 1,032 citations

The structure of an oligo(dA)·oligo(dT) tract and its biological implications

1987 • 975 citations

Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

1984 • 887 citations

Genetic Analysis of the Human Malaria Parasite Plasmodium falciparum

1987 • 719 citations

Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum

1984 • 716 citations

Molecular cell biology

1987 • 685 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum

1987 • 471 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Secretion of a malarial histidine-rich protein (Pf HRP II) from Plasmodium falciparum-infected erythrocytes.

1986 • 313 citations

Structurally Distinct, Stage-Specific Ribosomes Occur in Plasmodium

1987 • 309 citations

Eukaryotic protein modification and membrane attachment via phosphatidylinositol

1987 • 306 citations

MECHANISMS OF SPONTANEOUS AND INDUCED FRAMESHIFT MUTATION IN BACTERIOPHAGE T4

1985 • 292 citations

Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites

1985 • 286 citations

Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody.

1982 • 277 citations

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

1987 • 261 citations

Repetitive Proteins and Genes of Malaria

1987 • 259 citations

Characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum

1979 • 245 citations

Circumsporozoite Protein of Plasmodium vivax : Gene Cloning and Characterization of the Immunodominant Epitope

1985 • 235 citations

Multiple cross‐reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria

1986 • 235 citations

Immune sera recognize on erythrocytes a Plasmodium falciparum antigen composed of repeated amino acid sequences

1984 • 226 citations

Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum.

1986 • 220 citations

A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum

1987 • 211 citations

Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans.

1983 • 211 citations

Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein

1983 • 205 citations

Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum

1985 • 201 citations

OMPHALOCELE AND RAISED ALPHAFETOPROTEIN IN AMNIOTIC-FLUID

1975 • 199 citations

Circumsporozoite protein of Plasmodium berghei: gene cloning and identification of the immunodominant epitopes.

1986 • 198 citations

Circumsporozoite proteins of malaria parasites

1985 • 196 citations

Research Toward Malaria Vaccines

1986 • 190 citations

Evidence for clonal population structure in Escherichia coli.

1984 • 187 citations

Structure of the RESA gene ofPiasmodium falciparum

1986 • 185 citations

Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids

1983 • 182 citations

Knob-positive and knob-negative Plasmodium falciparum differ in expression of a strain-specific malarial antigen on the surface of infected erythrocytes.

1984 • 178 citations

Chromosome size polymorphisms in plasmodium falciparum can involve deletions and are frequent in natural parasite populations

1986 • 178 citations

A chromosomal rearrangement in a P. falciparum histidine-rich protein gene is associated with the knobless phenotype

1986 • 175 citations

Evolutionary Relatedness of Plasmodium Species as Determined by the Structure of DNA

1984 • 170 citations

Comparative analysis of thePlasmodium falciparumhistidine-rich proteins HRP-I, HRP-II and HRP-III in malaria parasites of diverse origin

1987 • 170 citations

Cloning and expression in E. coli of the malarial sporozoite surface antigen gene from Plasmodium knowlesi

1983 • 163 citations

Polymorphism of a high molecular weight schizont antigen of the human malaria parasite Plasmodium falciparum.

1985 • 162 citations

Mung Bean Nuclease Cleaves Plasmodium Genomic DNA at Sites Before and After Genes

1984 • 161 citations

A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae.

1985 • 157 citations

A liver-stage-specific antigen of Plasmodium falciparum characterized by gene cloning

1987 • 157 citations

Conserved sequences flank variable tandem repeats in two α-antigen genes of Plasmodium falciparum

1985 • 153 citations

Splenic requirement for antigenic variation and expression of the variant antigen on the erythrocyte membrane in cloned Plasmodium knowlesi malaria

1983 • 153 citations

Chromosome-Sized DNA Molecules of Plasmodium falciparum

1985 • 153 citations

The establishment of genomic DNA libraries for the human malaria parasite Plasmodium falciparum and identification of individual clones by hybridisation

1982 • 150 citations

Malaria — Resurgence, Resistance, and Research

1983 • 149 citations

ANALYSIS OF CLINICAL SPECIMENS BY HYBRIDISATION WITH PROBE CONTAINING REPETITIVE DNA FROM PLASMODIUM FALCIPARUM

1984 • 145 citations

Acylation of a Plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol.

1985 • 142 citations

Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes.

1985 • 141 citations

A repetitive antigen of Plasmodium falciparum that is homologous to heat shock protein 70 of Drosophila melanogaster.

1986 • 141 citations

Analysis of sequences from the extremely A + T-rich genome of Plasmodium falciparum

1987 • 136 citations

Gametocyte-Forming and Non-Gametocyte-Forming Clones of Plasmodium Falciparum

1984 • 132 citations

Molecular karyotype of Plasmodium falciparum: conserved linkage groups and expendable histidine-rich protein genes.

1987 • 128 citations

A malaria protein exported into a new compartment within the host erythrocyte.

1987 • 128 citations

Localization, biosynthesis, processing and isolation of a major 126 kDa antigen of the parasitophorous vacuole of Plasmodium falciparum

1987 • 126 citations

The genome of Plasmodium falciparum. I: DNA base composition

1982 • 124 citations

Antigenic variation of cloned Plasmodium fragile in its natural host Macaca sinica. Sequential appearance of successive variant antigenic types.

1987 • 123 citations

Molecular strategies of parasitic invasion

1986 • 122 citations

The development of Plasmodium ookinetes in vitro: an ultrastructural study including a description of meiotic division

1985 • 118 citations

Molecular biology of trypanosome antigenic variation

1985 • 114 citations

Identification of a telomeric DNA sequence in Plasmodium berghei.

1985 • 113 citations

Sequence variation in putative functional domains of the circumsporozoite protein of Plasmodium falciparum. Implications for vaccine development.

1987 • 111 citations

Localization of Plasmodium falciparum histidine-rich protein 1 in the erythrocyte skeleton under knobs

1987 • 111 citations

Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level.

1985 • 110 citations

DNA synthesis in Plasmodium berghei during asexual and sexual development

1986 • 110 citations

Membrane structure and function of malaria parasites and the infected erythrocyte

1985 • 108 citations

The circumsporozoite gene of the plasmodium cynomolgi complex

1987 • 106 citations

Epitope map and processing scheme for the 195,000-dalton surface glycoprotein of Plasmodium falciparum merozoites deduced from cloned overlapping segments of the gene.

1986 • 104 citations

A 75 kd merozoite surface protein of Plasmodium falciparum which is related to the 70 kd heat-shock proteins.

1987 • 104 citations

Characterization of an S antigen synthesized by several isolates of Plasmodium falciparum.

1983 • 103 citations

Stage-specific proteins and glycoproteins of plasmodium falciparum: identification of antigens unique to schizonts and merozoites.

1980 • 103 citations

Synthesis of DNA during the asexual cycle of Plasmodium falciparum in culture

1984 • 103 citations

Determination of nuclear DNA of five Eucoccidian parasites, Isospora (Toxoplasma) gondii, Sarcocystis cruzi, Eimeria tenella, E. acervulina and Plasmodium berghei, with special reference to gamontogenesis and meiosis in I. (T.) gondii

1984 • 103 citations

Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat

1984 • 101 citations

Surface proteins of Plasmodium falciparum merozoites binding to the erythrocyte receptor, glycophorin.

1984 • 100 citations

An ultrastructural study of the sporogonic development of Plasmodium falciparum in Anopheles gambiae

1978 • 99 citations

Characterisation of a repetitive DNA sequence from the malaria parasite, Plasmodium falciparum

1986 • 99 citations

Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.

1986 • 98 citations

A tandemly repeated sequence determines the binding domain for an erythrocyte receptor binding protein of P. falciparum

1986 • 98 citations

The cell biology of sexual development in Plasmodium

1983 • 96 citations

Sequence of the Immunodominant Epitope for the Surface Protein on Sporozoites ofPlasmodium vivax

1985 • 91 citations

Primary structure and subcellular localization of the knob-associated histidine-rich protein of Plasmodium falciparum.

1987 • 89 citations

Isolation of the Gene for a Glycophorin-Binding Protein Implicated in Erythrocyte Invasion by a Malaria Parasite

1985 • 89 citations

Variable antigen associated with the surface of erythrocytes infected with mature stages of Plasmodium falciparum

1986 • 87 citations

The four ribosomal DNA units of the malaria parasite Plasmodium berghei. Identification, restriction map, and copy number analysis.

1983 • 86 citations

Identification of the Meiotic Division of Malarial Parasites

1985 • 86 citations

The ring-infected erythrocyte surface antigen (RESA) polypeptide of Plasmodium falciparum contains two separate blocks of tandem repeats encoding antigenic epitopes that are naturally immunogenic in man.

1984 • 86 citations

Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. A rodent model for examining antimalarial sporozoite vaccines.

1987 • 85 citations

Primary structure and genomic organization of the histidine-rich protein of the malaria parasite Plasmodium lophurae

1984 • 84 citations

Plasmodium falciparum: Identification and localization of a knob protein antigen expressed by a cDNA clone

1987 • 84 citations

Membrane-Associated Electron-Dense Material of the Asexual Stages of Plasmodium falciparum: Evidence for Movement from the Intracellular Parasite to the Erythrocyte Membrane

1986 • 84 citations

Interspersed blocks of repetitive and charged amino acids in a dominant immunogen of Plasmodium falciparum.

1985 • 83 citations

[29] Orthogonal-field-alternation gel electrophoresis

1987 • 83 citations

Tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed

1987 • 83 citations

Plasmodium falciparum: Loss of knobs on the infected erythrocyte surface after long-term cultivation

1979 • 81 citations

Circular mitochondrial DNA from the avian malarial parasite Plasmodium lophurae

1975 • 80 citations

Strain variation in the circumsporozoite protein gene of Plasmodium falciparum

1987 • 80 citations

Transport of an Mr approximately 300,000 Plasmodium falciparum protein (Pf EMP 2) from the intraerythrocytic asexual parasite to the cytoplasmic face of the host cell membrane.

1987 • 78 citations

The complete sequence of the gene for the knob-associated histidine-rich protein from Plasmodium falciparum.

1987 • 77 citations

Sequence of the Small Subunit Ribosomal RNA Gene Expressed in the Bloodstream Stages of Plasmodium berghei: Evolutionary Implications¹

1986 • 76 citations

Monoclonal antibody characterization of Plasmodium falciparum antigens in immune complexes formed when schizonts rupture in the presence of immune serum.

1987 • 76 citations

Chromosome size polymorphisms of Leishmania donovani

1987 • 75 citations

Cloning and characterisation of the rRNA genes from the human malaria parasitePlasmodium falciparum

1983 • 71 citations

The Wellcome Trust Lecture: Genes for antigens ofPlasmodium falciparum

1986 • 71 citations

Structure of the circumsporozoite protein gene in 18 strains of Plasmodium falciparum

1985 • 71 citations

The gene for an exported antigen of the malaria parasitePlasmodium falciparumcloned and expressed inEscherichia coli

1985 • 69 citations

Diversity of Circumsporozoite Antigen Genes from Two Strains of the Malarial Parasite Plasmodium knowlesi

1985 • 68 citations

Sequence of a cDNA encoding a small polymorphic histidine- and alanine-rich protein fromPtasmodium falciparum

1985 • 68 citations

The Karyotype of Plasmodium falciparum Determined by Ultrastructural Serial Sectioning and 3D Reconstruction

1986 • 68 citations

Highly reiterated non-coding sequence in the genome of Plasmodium falciparum is composed of 21 base-pair tandem repeats

1985 • 67 citations

Molecular biology of trypanosome antigenic variation.

1985 • 65 citations

A blood stage antigen of Plasmodium falciparum shares determinants with the sporozoite coat protein.

1985 • 65 citations

Variation in the gene encoding a major merozoite surface antigen of the human malaria parasitePlasmodium falciparum

1986 • 63 citations

Leishmaniasis and Malaria: New Tools for Epidemiologic Analysis

1986 • 61 citations

The primary structure of a Plasmodium falciparum polypeptide related to heat shock proteins

1987 • 61 citations

Cloning and characterization of a ribosomal RNA gene from Plasmodium berghei

1983 • 60 citations

Plasmodium species: Flow cytometry and microfluorometry assessments of DNA content and synthesis

1987 • 60 citations

Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication

1987 • 59 citations

Analysis of protein variation in Plasmodium falciparum by two-dimentional gel electrophoresis

1981 • 59 citations

The Genetic Basis of Diversity in Malaria Parasites

1983 • 57 citations

Partial amino acid sequence of human thrombospondin as determined by analysis of cDNA clones: homology to malarial circumsporozoite proteins

1986 • 56 citations

Protein and nucleic acid synthesis during synchronized growth of Plasmodium falciparum

1984 • 55 citations

Protein variation in clones ofPlasmodium falciparum detected by two dimensional electrophoresis

1985 • 54 citations

Interspersed repetitive DNA from Plasmodium falciparum

1988 • 51 citations

Chromosomal variations in Candida albicans

1987 • 49 citations

Detection of Plasmodium Falciparum Using a Synthetic DNA Probe *

1985 • 49 citations

A calculation of fragment lengths obtainable from human DNA with 78 restriction enzymes: an aid for cloning and mapping

1986 • 47 citations

Characterisation of cDNA clones for hypoxanthine–guanine phosphoribosyltransferase from the human malarial parasite,Plasmodium falciparum: comparisons to the mammalian gene and protein

1987 • 47 citations

Cloning and expression in Escherichia coli of a surface antigen of Plasmodium falciparum merozoites.

1985 • 44 citations

Telomeric motifs are present in a highly repetitive element in the Plasmodium berghei genome

1987 • 43 citations

Allelic forms of gp195, a major blood-stage antigen of Plasmodium falciparum, are expressed in liver stages.

1988 • 42 citations

Plasmodium falciparum: Induction, selection, and characterization of pyrimethamine-resistant mutants

1986 • 40 citations

Synthesis of merozoite proteins and glycoproteins during the schizogony of Plasmodium falciparum

1984 • 40 citations

Kinetic complexity and repetitivity of Plasmodium berghei DNA

1980 • 40 citations

Stage-dependent processing and localization of a Plasmodium falciparum protein of 130,000 molecular weight

1988 • 40 citations

Histidine-rich domain of the knob protein of the human malaria parasite Plasmodium falciparum.

1986 • 40 citations

An asparagines–rich protein from blood stages ofPlasmodium falciparumshares determinants with sporozoites

1986 • 39 citations

Properties of DNA from some malarial parasites

1971 • 38 citations

Infectivity of Plasmodium berghei sporozoites measured with a DNA probe

1986 • 38 citations

Variations in the organization of repetitive DNA sequences in the genomes of Plasmodium falciparum clones

1985 • 38 citations

Plasmodium falciparum: Differentiation of isolates with DNA hybridization using antigen gene probes

1985 • 37 citations

Structure of the knob protein (KP) gene of Plasmodium falciparum

1987 • 37 citations

Sorting large numbers of clones expressing Plasmodium falciparum antigens in Escherichia coli by differential antibody screening.

1986 • 37 citations

Repeated Immunogenic Amino Acid Sequences of Plasmodium Species Share Sequence Homologies with Proteins from Humans and Human Viruses

1987 • 37 citations

Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum.

1987 • 36 citations

cDNA sequence encoding a Plasmodium falciparum protein associated with knobs and localization of the protein to electron-dense regions in membranes of infected erythrocytes.

1987 • 36 citations

DNA structure: Bent molecules—how and why?

1986 • 36 citations

Detection of Plasmodium falciparum DNA using repetitive DNA clones as species specific probes

1987 • 36 citations

A Plasmodium falciparum antigen containing clusters of asparagine residues.

1986 • 35 citations

The avian malariaPlasmodium lophuraehas a small number of heterogeneous ribosomal RNA genes

1983 • 35 citations

Putative glycophorin-binding protein is secreted from schizonts of Plasmodium falciparum

1987 • 34 citations

Application of the Serial Sectioning and Tridimensional Reconstruction Techniques to the Morphological Study of the Plasmodium falciparum Mitochondrion

1986 • 34 citations

Malaria — Resurgence, Resistance, and Research

1983 • 34 citations

Further studies and electron microscopic characterization of Plasmodium berghei DNA

1983 • 34 citations

Two plasmodium falciparum merozoite surface polypeptides share epitopes with a single Mr 185 000 parasite glycoprotein

1985 • 34 citations

Two major sequence classes of ribosomal RNA genes inPlasmodium berghei

1984 • 33 citations

Characterisation and translation studies of messenger RNA from the human malaria parasite Plasmodium falciparum and construction of a cDNA library

1984 • 32 citations

Isolation, Characterization and Synthesis of DNA from a Malaria Parasite*

1968 • 32 citations

Expression of Plasmodium falciparum surface antigens in Escherichia coli.

1985 • 32 citations

Plasmodium berghei, P. chabaudi, and P. falciparum: Similarities in phosphoproteins and protein kinase activities and their stage specific expression

1987 • 31 citations

Plasmodium berghei: Cloning of the circumsporozoite protein gene

1987 • 31 citations

Homologous telomeric sequences are present in different species of the genus Plasmodium

1986 • 29 citations

Organization and expression of the Plasmodium knowlesi circumsporozoite antigen gene

1987 • 29 citations

The S-antigen of Plasmodium falciparum Palo Alto represents a new S-antigen serotype

1988 • 29 citations

Sorting large numbers of clones expressing Plasmodium falciparum antigens in Escherichia coli by differential antibody screening.

1986 • 28 citations

Synthesis of small nuclear ribonucleoprotein particles by the malarial parasite Plasmodium falciparum.

1985 • 28 citations

Perspectives for malaria vaccination

1984 • 28 citations

Structure and expression of the knob-associated histidine-rich protein of Plasmodium falciparum

1987 • 27 citations

Acidic phosphoproteins associated with the host erythrocyte membrane of erythrocytes infected with Plasmodium berghei and P. chabaudi

1988 • 27 citations

Structure of the FIRA gene of Plasmodium falciparum.

1987 • 27 citations

Evolution of the immunodominant domain of the circumsporozoite protein gene from Plasmodium vivax. Implications for vaccines.

1987 • 26 citations

Sequence variation in S-antigen genes of Plasmodium falciparum.

1987 • 25 citations

Sensitive and specific DNA probe for detection of Plasmodium falciparum.

1986 • 24 citations

Characterization of a high-molecular-weight phosphoprotein synthesized by the human malarial parasite Plasmodium falciparum

1988 • 23 citations

Karyotype comparison betweenp.chabudiand P.falciparum:analysis of a P.ChabaudicDNA containing sequences highty repetitive in P.falciparum

1987 • 23 citations

An S antigen genome from Plasmodium falciparum contains a novel repetitive sequence

1988 • 23 citations

Antigenic diversity and size diversity of Plasmodium falciparum antigens in isolates from Gambian patients. I. S‐antigens

1986 • 21 citations

Induction and selection of drug resistant mutants of Plasmodium falciparum

1984 • 19 citations

The polymorphic 11.1 locus of Plasmodium falciparum

1987 • 19 citations

Conservation and antigenicity of N-terminal sequences of GP185 from different Plasmodium falciparum isolates

1986 • 19 citations

The three 5S rRNA genes from the human malaria parasite Plasmodium falciparum are linked

1988 • 19 citations

Cloning studies on the gene coding for l-(+)-lactate dehydrogenase of Plasmodium falciparum

1985 • 19 citations

Genome size and DNA complexity of Plasmodium falciparum

1982 • 18 citations

How the Malaria Parasite Invades Its Host Cell, the Erythrocyte

1985 • 17 citations

Characterization and complete nucleotide sequence of a 5.8S ribosomal RNA gene from Plasmodium falciparum

1987 • 16 citations

The importance of tRNA for the in vitro cell-free translation of messenger RNA isolated from the malaria parasite Plasmodium lophurae

1982 • 16 citations

Gametocytogenesis and ribosomal rRNA gene organisation in the rodent malarias Plasmodium chabaudi and Plasmodium berghei

1985 • 15 citations

Analysis of mRNA coding for blood-stage antigens of a rodent malarial parasite, Plasmodium yoelii: mRNA coding for a possible protective antigen purify as poly A-.

1984 • 15 citations

Identification of 5 S and 5.8 S ribosomal RNA molecules and their genes in Plasmodium berghei

1984 • 15 citations

The cloned rRNA genes ofP. lophurae:a novel rDNA structure

1983 • 14 citations

Identification and expression in Escherichia coli of merozoite stage-specific genes of the human malarial parasite Plasmodium falciparum.

1984 • 14 citations

Vaccination against malaria: Recent advances and the problems of antigenic diversity and other parasite evasion mechanisms

1987 • 14 citations

Structure and organization of the histidine-rich protein gene of Plasmodium lophurae

1986 • 14 citations

The synthesis and fate of stage-specific proteins in Plasmodium falciparum cultures

1983 • 13 citations

Antigenic diversity and size diversity of P. falciparum antigens in isolates from Gambian patients. II. The schizont surface glycoprotein of molecular weight ˜ 200 000

1986 • 12 citations

Preparation and characterization of DNA from rodent malarias

1972 • 11 citations

The biosynthesis of the histidine-rich protein of Plasmodium lophurae and the cloning of its gene in Escherichia coli

1985 • 10 citations

Mitomycin-C is an unreliable inhibitor for study of DNA synthesis in Plasmodium

1986 • 9 citations

The average spacing of restriction enzyme recognition sites in DNA

1982 • 9 citations

Plasmodium falciparum: Mapping genes to nine parasite chromosomes

1988 • 8 citations

Isolation of temperature-sensitive mutants of Plasmodium falciparum

1985 • 7 citations

Studies of antigens inPlasmodium yoelii

1984 • 4 citations

Organization ofPlasmodium falciparumgenome: ii. sequence analysis offalcielement

1986 • 1 citations

Deleted Work

1955 • 0 citations