Peripheral effects of neurokinins: functional evidence for the existence of multiple receptors

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor

1983 • 751 citations

Substance P as a Transmitter Candidate

1980 • 522 citations

The tachykinin peptide family

1981 • 470 citations

Neuromedin K: A novel mammalian tachykinin identified in porcine spinal cord

1983 • 432 citations

Suitability of urethane anesthesia for physiopharmacological investigations in various systems Part 1: General considerations

1986 • 389 citations

Novel neuropeptides, neurokinin .ALPHA. and .BETA., isolated from porcine spinal cord.

1983 • 357 citations

The possible existence of multiple receptors for substance P

1982 • 357 citations

Search for a physiological role of substance P in gastrointestinal motility

1985 • 336 citations

Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide

1985 • 332 citations

Novel Pharmacology of Substance K-Binding Sites: a Third Type of Tachykinin Receptor

1984 • 287 citations

Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig

1985 • 280 citations

A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation

1981 • 266 citations

Sensory substance P-innervation of the urinary bladder: Possible site of action of capsaicin in causing urine retention in rats

1983 • 220 citations

THE ROLE OF NEUROPEPTIDES IN THE REGULATION OF THE MICTURITION REFLEX

1986 • 204 citations

Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.

1985 • 193 citations

Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system

1986 • 192 citations

Substance K : A novel mammalian tachykinin that differs from substance P in its pharmacological profile

1984 • 153 citations

Tissue selectivity of substance P alkyl esters: Suggesting multiple receptors

1983 • 144 citations

Distribution of substance P in the rat gastrointestinal tract — Lack of effect of capsaicin pretreatment

1980 • 142 citations

Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions

1986 • 141 citations

Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord

1984 • 136 citations

Comparison of cardiovascular and bronchoconstrictor effects of substance P, substance K and other tachykinins

1984 • 133 citations

The effects of topical capsaicin on rat urinary bladder motility in vivo

1984 • 133 citations

Distribution of capsaicin-sensitive nerve fibres containing immunoreactive substance P in cutaneous and visceral tissues of the rat

1982 • 129 citations

Systemic capsaicin treatment impairs the micturition reflex in the rat

1984 • 123 citations

Mini Review: Smooth Muscle Pharmacology of Substance P

1982 • 117 citations

Regional distribution of kassinin-like immunoreactivity in rat central and peripheral tissues and the effect of capsaicin

1984 • 114 citations

Antisera raised against eledoisin and kassinin detect immunoreactive material in rat tissue extracts: tissue distribution and chromatographic characterization

1984 • 112 citations

Antidromic vasodilatation and neurogenic inflammation

1986 • 109 citations

Substance P – Structure-Activity Studies and the Development of Antagonists

1984 • 106 citations

Are the proposed substance P receptor sub-types, substance P receptors?

1984 • 101 citations

NEURONAL PEPTIDES IN THE INTESTINE

1982 • 87 citations

Receptors for substance P. III. Classification by competitive antagonists

1984 • 68 citations

The contractile activities of neurokinin A, B and related peptides on smooth muscles

1986 • 65 citations

Comparison of potency of substance P and related peptides on [3H]-acetylcholine release, and contractile actions, in the guinea-pig ileum

1984 • 57 citations

Pharmacological characterisation of a novel tachykinin isolated from mammalian spinal cord

1984 • 57 citations

Tachykinin receptors in smooth muscles: A study with agonists (substance P, neurokinin A) and antagonists

1985 • 55 citations

Substance P, 5-hydroxytryptamine, and bradykinin stimulate abdominal visceral afferents

1986 • 53 citations

Dual effects of clonidine on micturition reflex in urethane anesthetized rats.

1985 • 49 citations

Further evidence for multiple tachykinin receptors

1982 • 46 citations

Comparison of the effects of substance P and substance K on blood pressure, salivation and urinary bladder motility in urethane-anaesthetized rats

1985 • 46 citations

Receptors for substance P. II. Classification by agonist fragments and homologues

1984 • 46 citations

Lack of algesic effect of substance P on paravascular pain receptors

1977 • 46 citations

In vivo and in vitro actions of mammalian tachykinins

1985 • 45 citations

MODULATION BY β‐ADRENORECEPTORS OF SPONTANEOUS CONTRACTIONS OF RAT URINARY BLADDER

1982 • 45 citations

Sympathetic inhibition of reflex activation of bladder motility during filling at a physiological‐like rate in urethane anaesthetized rats

1985 • 42 citations

A comparison of the effects of three substance P antagonists on tachykinin‐stimulated [³H]‐acetylcholine release in the guinea‐pig ileum

1986 • 39 citations

Autoradiographic distribution of substance K binding sites in rat gastrointestinal tract: A comparison with substance P

1984 • 39 citations

A pharmacological study with substance K: Evidence for multiple types of tachykinin receptors

1984 • 38 citations

Motor effect of neurokinins on the rat duodenum: evidence for the involvement of substance K and substance P receptors.

1986 • 37 citations

Untersuchungen �ber die Ausl�sung afferenter Impulse

1957 • 36 citations

Activation of micturition reflex by substance P and substance K: indirect evidence for the existence of multiple tachykinin receptors in the rat urinary bladder.

1986 • 36 citations

Cholinergic Mechanisms in the Rat Detrusor Muscle

1978 • 33 citations

An examination of the pharmacology of two substance P antagonists and the evidence for tachykinin receptor subtypes

1986 • 32 citations

Stereospecificity of SP1 and SP2 substance P receptors

1985 • 29 citations

Effect of a novel tachykinin, substance K, on salivation in rats

1985 • 29 citations

Peptide antagonists

1985 • 26 citations

The determination of dissociation constants for substance P and substance P analogues in the guinea pig ileum by pharmacological procedures.

1983 • 24 citations

Effects of substance P antagonists on the atropine-sensitive and atropine-resistant responses of guinea-pig ileum to substance P

1985 • 23 citations

Interaction of tachykinins with an adrenergic receptor in the rat urinary bladder

1985 • 6 citations

EFFECT OF SUBSTANCE P AND OTHER TACHYKININS ON ARTERIAL PRESSURE IN GUINEA‐PIGS

1985 • 5 citations