The increase in human plasma immunoreactive endothelin but not big endothelin‐1 or its C‐terminal fragment induced by systemic administration of the endothelin antagonist TAK‐044

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

A practical computer-based approach to the analysis of radioligand binding experiments

1983 • 834 citations

Contribution of endogenous generation of endothelin-1 to basal vascular tone

1994 • 588 citations

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure

1995 • 575 citations

Systemic Endothelin Receptor Blockade Decreases Peripheral Vascular Resistance and Blood Pressure in Humans

1996 • 326 citations

Endothelin ET_A and ET_B mRNA and receptors expressed by smooth muscle in the human vasculature: majority of the ET_A sub‐type

1995 • 160 citations

ET_A receptor‐mediated constrictor responses to endothelin peptides in human blood vessels in vitro

1995 • 142 citations

Is endothelin-induced vasoconstriction mediated only by ETA receptors in humans?

1994 • 140 citations

Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney

1993 • 135 citations

Effect of different endothelin receptor antagonists and of the novel non‐peptide antagonist Ro 46‐2005 on endothelin levels in rat plasma

1993 • 122 citations

The Clinical Potential of Endothelin Receptor Antagonists in Cardiovascular Medicine

1996 • 81 citations

Long-lasting vasoconstriction and efficient regional extraction of endothelin-1 in human splanchnic and renal tissues

1991 • 76 citations

Regional Hemodynamic Effects and Clearance of Endothelin-1 in Humans

1992 • 72 citations

Expression of Endothelin Peptides and Mrna in the Human Heart

1996 • 60 citations

Phosphoramidon inhibition of the in vivo conversion of big endothelin-1 to endothelin-1 in the human forearm

1995 • 53 citations

Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs

1995 • 52 citations

Role of Endogenous Endothelin-1 in Experimental Renal Hypertension in Dogs

1995 • 50 citations

Cyclic Hexapeptide Endothelin Receptor Antagonists Highly Potent for Both Receptor Subtypes ETA and ETB

1994 • 48 citations

Endothelin: a knockout in London

1995 • 22 citations

Measurement of C-Terminal Fragment of Big Endothelin-1

1995 • 12 citations