Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review

Pharmacological interventions for somatoform disorders in adults

2014 • 11,438 citations

Interrater Reliability of a Modified Ashworth Scale of Muscle Spasticity

1987 • 4,997 citations

Current methods of the U.S. Preventive Services Task Force

2001 • 1,727 citations

PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS.

1964 • 1,491 citations

A review of the properties and limitations of the Ashworth and modified Ashworth Scales as measures of spasticity

1999 • 768 citations

Antidepressant Treatment of Fibromyalgia: A Meta-Analysis and Review

2000 • 460 citations

Comparison of Amitriptyline, Cyclobenzaprine, and Placebo in the Treatment of Fibromyalgia

1994 • 339 citations

Antispasticity drugs: Mechanisms of action

1985 • 339 citations

Anti-spasticity agents for multiple sclerosis

2003 • 261 citations

Spasticity: a review.

1994 • 258 citations

Tizanidine

1997 • 200 citations

Acute Low-Back Pain

1980 • 188 citations

A comparison of cyclobenzaprine and placebo in the management of fibrositis

1988 • 188 citations

Medication Use for Low Back Pain in Primary Care

1998 • 180 citations

Drugs Used to Treat Spasticity

2000 • 168 citations

Dantrolene-Associated Hepatic Injury

1977 • 145 citations

Pain and Spasticity After Spinal Cord Injury

2001 • 141 citations

Cyclobenzaprine and Back Pain

2001 • 137 citations

Chronic Daily Headache Prophylaxis With Tizanidine: A Double‐Blind, Placebo‐Controlled, Multicenter Outcome Study

2002 • 136 citations

Drug Therapy for Back Pain

1996 • 130 citations

Tizanidine and Ibuprofen in Acute Low-Back Pain: Results of a Double-Blind Multicentre Study in General Practice

1988 • 125 citations

Evaluation of treatment protocols on minimal to moderate spasticity in multiple sclerosis.

1991 • 113 citations

Tizanidine in Chronic Tension‐Type Headache: A placebo controlled double‐blind cross‐over study

1992 • 110 citations

Clinical scales for multiple sclerosis

1996 • 109 citations

Cyclobenzaprine hydrochloride effect on skeletal muscle spasm in the lumbar region and neck: two double-blind controlled clinical and laboratory studies.

1978 • 100 citations

Baclofen, A New Antispastic Drug

1977 • 98 citations

An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions: A double-blind, cross-over study

1976 • 95 citations

A Controlled Trial of Baclofen in Children with Cerebral Palsy

1973 • 94 citations

A Multicentre Placebo-Controlled Study in General Practice to Evaluate the Efficacy and Safety of Tizanidine in Acute Low-Back Pain

1988 • 93 citations

The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.

1991 • 92 citations

Pharmacological interventions for spasticity following spinal cord injury

2000 • 91 citations

Complications of baclofen overdosage

1980 • 90 citations

Management of Fibromyalgia

1999 • 89 citations

Baclofen for spasticity in multiple sclerosis Double‐blind crossover and three‐year study

1978 • 86 citations

Tizanidine Versus Baclofen in the Treatment of Spasticity in Patients with Multiple Sclerosis

1988 • 86 citations

Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American Tizanidine Study Group.

1994 • 86 citations

Prospective assessment of tizanidine for spasticity due to acquired brain injury

2001 • 85 citations

Baclofen Toxicity in Patients with Severely Impaired Renal Function

1997 • 79 citations

A comparison of baclofen and diazepam in the treatment of spasticity

1974 • 79 citations

Baclofen

1974 • 79 citations

Dantrolene sodium and hepatic injury

1990 • 78 citations

A randomized trial of cyclobenzaprine for the treatment of fibromyalgia.

1989 • 75 citations

A Comparison of Clonidine, Cyproheptadine and Baclofen in Spastic Spinal Cord Injured Patients

1994 • 73 citations

Prophylactic Pharmacological Treatment of Chronic Daily Headache

2000 • 73 citations

Tizanidine versus baclofen in the treatment of spasticity in multiple sclerosis patients

1988 • 73 citations

A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia

1988 • 72 citations

The treatment of spasticity in multiple sclerosis: a double-blind clinical trial of a new anti-spastic drug tizanidine compared with baclofen

1987 • 72 citations

Acute Back Pain and Spasm

1989 • 70 citations

Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis

1982 • 68 citations

Treatment of Spasticity with Tizanidine in Multiple Sclerosis

1987 • 68 citations

Tizanidine in the treatment of spasticity

1982 • 66 citations

Cyclobenzaprine and naproxen versus naproxen alone in the treatment of acute low back pain and muscle spasm.

1990 • 65 citations

The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients

2000 • 64 citations

Tizanidine treatment of spasticity: a meta-analysis of controlled, double-blind, comparative studies with baclofen and diazepam.

1998 • 63 citations

Summary of combined clinical analysis of controlled clinical trials with tizanidine.

1994 • 61 citations

Carisoprodol (Soma)

1999 • 60 citations

A DOUBLE-BLIND TRIAL WITH BACLOFEN (LIORESAL®) AND DIAZEPAM IN SPASTICITY DUE TO MULTIPLE SCLEROSIS

2009 • 60 citations

Comparison of dantrolene sodium and diazepam in the treatment of spasticity.

1976 • 60 citations

Development of preliminary criteria for response to treatment in fibromyalgia syndrome.

1991 • 58 citations

Dantrolene Sodium Suspension in Treatment of Spastic Cerebral Palsy

1980 • 58 citations

Modified‐Release Formulation of Tizanidine in Chronic Tension‐type Headache

2000 • 58 citations

Cyclobenzaprine in Intractable Pain Syndromes With Muscle Spasm

1978 • 55 citations

Long-term treatment with dantrolene sodium of stroke patients with spasticity limiting the return of function

1984 • 55 citations

Baclofen for the Treatment of Acute Low-Back Syndrome

1985 • 55 citations

The effect of dantrolene sodium on spasticity in multiple sclerosis

1973 • 55 citations

Baclofen in the elderly stroke patient its side-effects and pharmacokinetics

1985 • 54 citations

Comparative profile of tizanidine in the management of spasticity.

1994 • 53 citations

Objective assessment of spasticity, strength, and function with early exhibition of dantrolene sodium after cerebrovascular accident: a randomized double-blind study.

1992 • 52 citations

A Double-Blind Crossover Study of Two Cyclobenzaprine Regimens in Primary Fibromyalgia Syndrome

1993 • 52 citations

Multi-centre, double-blind trial of a novel antispastic agent, tizanidine, in spasticity associated with multiple sclerosis

1988 • 52 citations

On the site of action of diazepam in spasticity in man

1967 • 51 citations

A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis.

1981 • 50 citations

Hyperthermia associated with baclofen withdrawal and increased spasticity.

1993 • 49 citations

Prolonged seizure activity after baclofen withdrawal

1992 • 48 citations

Pharmacology of spasticity

1978 • 48 citations

A DOUBLE-BLIND COMPARISON OF QUININE SULPHATE AND PLACEBO IN MUSCLE CRAMPS

1983 • 47 citations

A double-blind, long-term study of tizanidine ('Sirdalud) in spasticity due to cerebrovascular lesions

1989 • 47 citations

Dantrolene sodium in children with spasticity.

1974 • 47 citations

Abuse of skeletal muscle relaxants.

1991 • 46 citations

The Use of Baclofen in Treatment of Spasticity in Multiple Sclerosis

1979 • 46 citations

A New Skeletal Muscle Relaxant (DS 103-282*) Compared to Diazepam in the Treatment of Muscle Spasm of Local Origin

1981 • 43 citations

Assessment of Functional Limitation and Disability in Patients with Fibromyalgia

1997 • 42 citations

Baclofen versus diazepam for the treatment of spasticity and long-term follow-up of baclofen therapy.

1985 • 40 citations

Meprobamate Overdosage: A Continuing Problem

1977 • 40 citations

Tizanidine (DS 103-282) in the Treatment of Acute Paravertebral Muscle Spasm: A Controlled Trial Comparing Tizanidine and Diazepam

1981 • 40 citations

Baclofen overdose

1980 • 40 citations

Neurological Manifestations of Baclofen Withdrawal

1993 • 36 citations

Chlorzoxazone Hepatotoxic Reactions

1986 • 36 citations

Dyskinesia and psychosis in a patient following baclofen withdrawal

1984 • 35 citations

Comparison of carisoprodol, butabarbital, and placebo in treatment of the low back syndrome.

1972 • 33 citations

Treatment of Spastic Cerebral‐palsied Children with Sodium Dantrolene

1975 • 33 citations

Tizanidine in the management of spasticity and musculoskeletal complaints in the palliative care population

2000 • 31 citations

Meprobamate overdosage: a continuing problem sensitive GC-MS quantitation after solid phase extraction in 19 fatal cases

1997 • 28 citations

Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases

1986 • 27 citations

A Comparison of Two Analgesic Muscle Relaxant Combinations in Acute Back Pain

1984 • 26 citations

Medical Treatment for Spasticity in Children with Cerebral Palsy

1976 • 26 citations

A case of tizanidine-induced hepatic injury

1996 • 25 citations

Acute Low Back Pain

1988 • 25 citations

Current pharmacologic treatment of multiple sclerosis symptoms.

1996 • 25 citations

A comparison of dantrolene sodium and diazepam in the treatment of spasticity

1974 • 25 citations

A double-blind comparative study of carisoprodol, propoxyphene, and placebo in the management of low back syndrome.

1976 • 24 citations

A study of metaxalone (Skelaxin) vs. placebo in acute musculoskeletal disorders: a cooperative study.

1975 • 24 citations

Medical management of spasticity in stroke

2001 • 23 citations

Assessment of cyclobenzaprine in the treatment of spasticity

1972 • 23 citations

A Double-Blind Comparison in General Practice of a Combination Tablet Containing Orphenadrine Citrate and Paracetamol (‘Norgesic') with Paracetamol Alone

1983 • 23 citations

Dantrolene sodium in athetoid cerebral palsy.

1973 • 23 citations

A SECOND LOOK AT A SKELETAL MUSCLE RELAXANT: A DOUBLE-BLIND STUDY OF METAXALONE.

1964 • 22 citations

CYCLOBENZAPRINE IN THE TREATMENT OF CHRONIC TENSION HEADACHE

1972 • 22 citations

Adverse Effects Secondary to Baclofen Withdrawal

1985 • 20 citations

Baclofen: A Team Approach to Drug Evaluation of Spasticity in Childhood

1980 • 20 citations

Dantrolene sodium for treatment of spasticity.

1974 • 20 citations

Spasticity and the effect of dantrolene sodium.

1974 • 20 citations

A double-blind, placebo-controlled trial of tizanidine in the treatment of spasticity caused by multiple sclerosis. United Kingdom Tizanidine Trial Group.

1994 • 19 citations

Dantrolene sodium in the treatment of spasticity in chronic spinal cord disease.

1978 • 19 citations

Efficacy and gastroprotective effects of tizanidine plus diclofenac versus placebo plus diclofenac in patients with painful muscle spasms

1998 • 18 citations

Treatment of Spasticity in Multiple Sclerosis With Dantrolene

1975 • 18 citations

A controlled study of methocarbamol (Robaxin) in acute painful musculoskeletal conditions.

1975 • 18 citations

The Supraspinal Anxiolytic Effect of Baclofen for Spasticity Reduction

1990 • 17 citations

Lioresal (baclofen) treatment of spasticity in multiple sclerosis.

1975 • 16 citations

Double-Blind Study of Metaxalone

1966 • 14 citations

Dantrolene sodium in chronic spasticity of varying etiology

1982 • 14 citations

Effects of a GABA--derivative (BA-34647) on spasticity. Preliminary report of a double-blind cross-over study.

1974 • 13 citations

Parafon Forte versus Robaxisal in skeletal muscle disorders: a double-blind study.

1976 • 13 citations

Spasmolytic Properties of Dantrolene Sodium: Clinical Evaluation

1975 • 12 citations

A controlled clinical trial of chlormezanone, orphenadrine, orphenadrine/paracetamol and placebo in the treatment of painful skeletal muscle spasms.

1975 • 11 citations

A double-blind, multicenter trial of Methacarbamol (Robaxin) and cyclobenzaprine (Flexeril) in acute musculoskeletal conditions

1984 • 11 citations

A comparative study of Parafon Forte tablets and soma compound in the treatment of painful skeletal muscle conditions.

1976 • 9 citations

Dantrolene sodium in the treatment of spasticity caused by multiple sclerosis or degenerative myelopathies: A double-blind, cross-over study in comparison with placebo

1983 • 9 citations

Effect of Dantrolene Sodium on the Incidence of Seizures in Children with Spasticity

1979 • 8 citations

A double-blind evaluation of Parafon Forte in the treatment of musculo-skeletal back conditions.

1972 • 8 citations

Preliminary Communication:Chlorzoxazone (Parafiex) in the Treatment of Severe Spasticity

1966 • 8 citations

Value of an acetaminophen-chlorzoxazone combination (parafon forte) in the treatment of acute musculoskeletal disorders.

1973 • 5 citations

Methocarbamol in the Treatment of Cerebral Palsy in Children

1971 • 5 citations

Deleted Work

1955 • 0 citations