Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

1984 • 767 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

1997 • 493 citations

Induction of immunological paralysis in two zones of dosage

1964 • 439 citations

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

1962 • 386 citations

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

1986 • 344 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

LONG-TERM RESULTS OF A CONTROLLED PROSPECTIVE STUDY WITH TRANSFUSION OF DONOR-SPECIFIC BONE MARROW IN 57 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

1991 • 285 citations

T-cell memory: the connection between function, phenotype and migration pathways

1991 • 271 citations

The lost chord: microchimerism and allograft survival

1996 • 259 citations

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

1993 • 256 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

On the role of antigen in maintaining cytotoxic T-cell memory.

1996 • 237 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Chimerism and transplantation tolerance: cause and effect

1996 • 217 citations

Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes

1988 • 212 citations

T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?

1986 • 210 citations

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

1991 • 165 citations

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

1998 • 161 citations

Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection

1976 • 159 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without “memory T cells”?

1997 • 131 citations

Peptide Antigen Treatment of Naive and Virus-Immune Mice: Antigen-Specific Tolerance Versus Immunopathology

1997 • 126 citations

The Influence of Allogeneic Cells on the Human T and B Cell Repertoire

1990 • 108 citations

Immunological activity of covalently linked T-cell epitopes

1990 • 95 citations

The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients.

1997 • 91 citations

Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen.

1984 • 90 citations

A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro

1997 • 87 citations

The Importance of Chimerism in Maintaining Tolerance of Skin Allografts in Mice

1973 • 73 citations

The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection

1987 • 72 citations

In vivo induction of tolerance in murine CD4+ cell subsets.

1993 • 68 citations

T cell deletion follows chronic antigen specific T cell activation in vivo

1993 • 68 citations

The immune response of the mouse to lymphocytic choriomeningitis virus

1983 • 64 citations

Alloantigen persistence in induction and maintenance of transplantation tolerance.

1987 • 62 citations

Paralysis to serum albumins in T and B lymphocytes in mice. Dose dependence, specificity and kinetics of escape

1974 • 51 citations

T cell tolerance and activation to a transgene‐encoded tumor antigen

1996 • 39 citations

Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice.

1993 • 34 citations

Reduction of the in Vitro Cytotoxic Lymphocyte Response Produced by in Vivo Exposure to Semiallogeneic Cells: Recruitment or Active Suppression?

1976 • 30 citations

Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: A 44 month follow-up

1997 • 20 citations