Immune stimulating complexes as mucosal vaccines

Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses

1984 • 696 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Adjuvants for human vaccines—current status, problems and future prospects

1995 • 546 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs

1990 • 479 citations

Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

1994 • 383 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.

1994 • 184 citations

Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route.

1991 • 174 citations

The requirement of lipids for the formation of immunostimulating complexes (iscoms)

1988 • 158 citations

Liposomes and ISCOMS as vaccine formulations

1995 • 154 citations

Macrophages as accessory cells for class I MHC-restricted immune responses.

1991 • 148 citations

Induction of protective immune response in cats by vaccination with feline leukemia virus iscom.

1985 • 144 citations

Vaccines for the Third World

1989 • 136 citations

Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM matrix

1995 • 134 citations

The ISCOM: an immunostimulating complex

1987 • 128 citations

Iscoms Containing PurifiedQuillajaSaponins Upregulate both Th1-like and Th2-like Immune Responses

1997 • 109 citations

Cellular Immune Responses in the Murine Lung to Local Immunization with Influenza A Virus Glycoproteins in Micelles and Immunostimulatory Complexes (Iscoms)

1988 • 98 citations

Vaccination of class I major histocompatibility complex (MHC)-restricted murine CD8+ cytotoxic T lymphocytes towards soluble antigens: immunostimulating-ovalbumin complexes enter the class I MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide

1991 • 97 citations

Immune-stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens.

1993 • 90 citations

An experimental influenza subunit vaccine (iscom): induction of protective immunity to challenge infection in mice after intranasal or subcutaneous administration

1990 • 89 citations

Induction of Th1 and Th2 CD4⁺ T cell responses by oral or parenteral immunization with ISCOMS

1995 • 88 citations

The Serum Antibody Response Distributed in Subclasses and Isotypes after Intranasal and Subcutaneous Immunization with Influenza Virus Immunostimulating Complexes

1988 • 87 citations

Secretory immune responses in the mouse vagina after parenteral or intravaginal immunization with an immunostimulating complex (ISCOM)

1991 • 77 citations

Novel vaccination strategies for the control of mucosal infection

1993 • 76 citations

Protection against lethal measles virus infection in mice by immune-stimulating complexes containing the hemagglutinin or fusion protein

1987 • 73 citations

Immunostimulating Complexes

1995 • 73 citations

Influenza virus ISCOMs: antibody response in animals

1988 • 70 citations

Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid

1992 • 67 citations

Initiation of cytotoxic T-cell response and protection of Balb/c mice by vaccination with an experimental ISCOMs respiratory syncytial virus subunit vaccine

1992 • 66 citations

Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into iscoms

1990 • 64 citations

The iscom antigen-presenting system

1988 • 62 citations

Effect of iscoms and their adjuvant moiety (matrix) on the initial proliferation and IL-2 responses: Comparison of spleen cells from mice inoculated with iscoms and/or matrix

1990 • 58 citations

Incorporation of the major outer membrane protein of Neisseria gonorrhoeae in saponin-lipid complexes (iscoms): chemical analysis, some structural features, and comparison of their immunogenicity with three other antigen delivery systems

1988 • 57 citations

Differential Effects of LPS and CD40 Ligand Stimulations on the Induction of IL-12 Production by Dendritic Cells and Macrophages

1997 • 56 citations

Antigen presentation by naive macrophages, dendritic cells and B cells to primed T lymphocytes and their cytokine production following exposure to immunostimulating complexes

1995 • 52 citations

IMMUNOMODULATION BYQUILLAJA SAPONARIAADJUVANT FORMULATIONS: IN VIVO STIMULATION OF INTERLEUKIN 12 AND ITS EFFECTS ON THE ANTIBODY RESPONSE

1997 • 50 citations

Involvement of Interleukin‐2 and Interferon‐Gamma in the Immune Response Induced by Influenza Virus Iscoms

1992 • 50 citations

Adjuvant effects of orally administered saponins on humoral and cellular immune responses in mice

1987 • 50 citations

Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs

1994 • 46 citations

Saponin

1992 • 46 citations

Immunomodulatory Effects of Orally-Administered Saponins and Nonspecific Resistance against Rabies Infection

1987 • 39 citations

Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization

1996 • 34 citations

Antibody Responses and Protection in Mice Immunized with Herpes Simplex Virus Type 1 Antigen Immune-stimulating Complex Preparations

1989 • 34 citations

IN VIVO AND IN VITRO INDUCTION OF IL-6 BYQUILLAJA SAPONARIAMOLINA TRITERPENOID FORMULATIONS

1997 • 34 citations

Incorporation of soluble antigens into ISCOMs: HIV gp120 ISCOMs induce virus neutralizing antibodies

1992 • 34 citations

Comparative antibody responses and protection in mice immunised by oral or parenteral routes with influenza virus subunit antigens in aqueous form or incorporated into ISCOMs

1995 • 32 citations

Immunogenicity of liposomes and iscoms containing the major outer membrane protein of Neisseria gonorrhoeae: influence of protein content and liposomal bilayer composition

1988 • 28 citations

Protection of mice against an influenza virus infection by oral vaccination with viral nucleoprotein incorporated into immunostimulating complexes

1994 • 28 citations

Immunization with Trypanosoma cruzi epimastigote antigens incorporated into iscoms protects against lethal challenge in mice

1991 • 25 citations

Adjuvanted subunit vaccines for the control of Salmonella enteritidis infection in turkeys

1994 • 24 citations

Preservation of mucosal and systemic adjuvant properties of ISCOMS in the absence of functional interleukin‐4 or interferon‐γ

1998 • 21 citations

Long-term toxicity study of quillaia extract in mice

1979 • 19 citations

Immune response after immunization with an experimental Toxoplasma gondii ISCOM vaccine

1991 • 17 citations

ADVANCES IN MUCOSAL IMMUNOLOGY

1997 • 15 citations

Induction of Systemic and Mucosal Immune Responses Following Immunization with Somatostatin-Avidin Complexes Incorporated Into Iscoms

1995 • 13 citations

Fluorescent labelling of virus, bacteria and iscoms: in vivo systemic and mucosal localisation patterns.

1995 • 8 citations

Preparation of Immune Stimulating Complexes (<scp>ISCOM</scp>s) as Adjuvants

1995 • 8 citations

Iscom (Immunostimulating Complex) Vaccines Containing Mono‐ or Polyvalent Pili of Enterotoxigenic E. coli; Immune Response of Rabbit and Swine

1990 • 7 citations

The basis of the oral and parenteral adjuvant properties of immune stimulating complexes (ISCOMS).

1996 • 2 citations