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Abstract

References (93)

Mate selection—A selection for a handicap

1975 • 5,212 citations

Genetics and the Origin of Species

1952 • 4,122 citations

Drug Addiction, Dysregulation of Reward, and Allostasis

2001 • 2,820 citations

Psychiatric disorders in America: the epidemiologic catchment area study

1991 • 2,589 citations

The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence

1985 • 2,357 citations

Temperament: Early Developing Personality Traits

1984 • 2,164 citations

Inheritance of Alcohol Abuse

1981 • 1,873 citations

The inheritance of liability to certain diseases, estimated from the incidence among relatives

1965 • 1,618 citations

Psychiatric disorders in America

1991 • 1,574 citations

Addiction Is a Brain Disease, and It Matters

1997 • 1,486 citations

Etiologic connections among substance dependence, antisocial behavior and personality: Modeling the externalizing spectrum.

2002 • 1,350 citations

Sources of Human Psychological Differences: The Minnesota Study of Twins Reared Apart

1990 • 1,336 citations

Genetics and the Origin of Species

1952 • 1,221 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ 1 Opioid Receptor Mechanism

1997 • 1,078 citations

Stages of progression in drug involvement from adolescence to adulthood: further evidence for the gateway theory.

1992 • 1,051 citations

The dopamine hypothesis of reward: past and current status

1999 • 981 citations

Attention-Deficit Hyperactivity Disorder: A Category or a Continuum? Genetic Analysis of a Large-Scale Twin Study

1997 • 973 citations

Alcohol Problems in Adoptees Raised Apart From Alcoholic Biological Parents

1973 • 895 citations

Familial Transmission of Substance Use Disorders

1998 • 762 citations

Dopamine neurons and their role in reward mechanisms

1997 • 757 citations

Co-occurrence of Abuse of Different Drugs in Men

1998 • 713 citations

Specificity of Genetic and Environmental Risk Factors for Use and Abuse/Dependence of Cannabis, Cocaine, Hallucinogens, Sedatives, Stimulants, and Opiates in Male Twins

2003 • 681 citations

Psychobiology of novelty seeking and drug seeking behavior

1996 • 672 citations

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

1999 • 630 citations

Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

1989 • 579 citations

Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration

1990 • 574 citations

The neurobiology of drug addiction

1997 • 564 citations

Drinking Problems in Adopted and Nonadopted Sons of Alcoholics

1974 • 514 citations

Is ADHD a Risk Factor for Psychoactive Substance Use Disorders? Findings From a Four-Year Prospective Follow-up Study

1997 • 487 citations

From beer to crack: developmental patterns of drug involvement.

1993 • 485 citations

Familial Transmission of Substance Dependence: Alcohol, Marijuana, Cocaine, and Habitual Smoking

1998 • 476 citations

Maternal Inheritance of Alcohol Abuse

1981 • 468 citations

A Population-Based Twin Study of Alcoholism in Women

1992 • 459 citations

Common Genetic Vulnerability for Nicotine and Alcohol Dependence in Men

1999 • 455 citations

Genetic and environmental influences on behavioral disinhibition

2000 • 443 citations

Behavior of Boys in Kindergarten and the Onset of Substance Use During Adolescence

1997 • 440 citations

A cannabinoid mechanism in relapse to cocaine seeking

2001 • 434 citations

Adult Disorders Predicted by Childhood Conduct Problems: Results from the NIMH Epidemiologic Catchment Area Project

1991 • 429 citations

Differential Influence of Associative and Nonassociative Learning Mechanisms on the Responsiveness of Prefrontal and Accumbal Dopamine Transmission to Food Stimuli in Rats FedAd Libitum

1997 • 374 citations

An Adoption Study of Genetic and Environmental Factors in Drug Abuse

1986 • 357 citations

Heritability of substance abuse and antisocial behavior: A study of monozygotic twins reared apart

1990 • 339 citations

Psychoactive Drug Use in Evolutionary Perspective

1997 • 334 citations

Sex and age effects on the inheritance of alcohol problems: A twin study.

1992 • 331 citations

Linkage of Antisocial Alcoholism to the Serotonin 5-HT1B Receptor Gene in 2 Populations

1998 • 322 citations

Acvclovir in herpes zoster.

1981 • 312 citations

Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB

1996 • 293 citations

Etiology of early age onset substance use disorder: A maturational perspective

1999 • 275 citations

Alcohol abuse and dependence

2003 • 274 citations

Cannabis Use, Abuse, and Dependence in a Population-Based Sample of Female Twins

1998 • 267 citations

Attention-Deficit Hyperactivity Disorder Dimensions: A Twin Study of Inattention and Impulsivity-Hyperactivity

1997 • 256 citations

Genetic and Environmental Influences on the Covariation Between Hyperactivity and Conduct Disturbance in Juvenile Twins

1996 • 243 citations

Genetic and environmental influences on drug use and abuse/dependence in male and female twins

1998 • 236 citations

Abolition and Reversal of Strain Differences in Behavioral Responses to Drugs of Abuse After a Brief Experience

2000 • 235 citations

Can We Subtype Alcoholism? A Latent Class Analysis of Data from Relatives of Alcoholics in a Multicenter Family Study of Alcoholism

1996 • 203 citations

Antisocial symptoms in preadolescent boys and in their parents: Associations with cortisol

1993 • 203 citations

Levels and correlates of polydrug use among heroin users and regular amphetamine users

1995 • 199 citations

Childhood psychopathology and development

1983 • 197 citations

Psychopathology in Adopted-Away Offspring of Biologic Parents With Antisocial Behavior

1978 • 190 citations

Alcoholism: A developmental disorder.

1994 • 185 citations

Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects

1997 • 181 citations

Boys Who Join Gangs: A Prospective Study of Predictors of First Gang Entry

1999 • 172 citations

Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism

1993 • 171 citations

Psychopathology and Substance-Related Problems During Early Adolescence: A Survival Analysis

1999 • 170 citations

Childhood Psychopathology and Development

1984 • 150 citations

Alcoholism: A developmental disorder.

1994 • 150 citations

The consumption of tobacco, alcohol, and coffee in caucasian male twins: A multivariate genetic analysis

1996 • 141 citations

A multivariate genetic analysis of sensation seeking

1995 • 139 citations

Cellular responses to chronic treatment with drugs of abuse.

1993 • 138 citations

Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs

2000 • 134 citations

Pharmacogenetics of alcohol metabolism and alcoholism

1992 • 134 citations

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence

1997 • 133 citations

Genetic studies of substance abuse

2000 • 120 citations

The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese.

1992 • 106 citations

Psychopathology in Preadolescent Sons of Fathers With Substance Use Disorders

1997 • 104 citations

Regulation of Serotonin Release in the Frontal Cortex and Ventral Hippocampus of Homozygous Mice Lacking 5‐HT1B Receptors: In Vivo Microdialysis Studies

1997 • 96 citations

EAS temperaments during the last half of the life span: Twins reared apart and twins reared together.

1988 • 92 citations

An adoption study of drug abuse/dependency in females

1996 • 88 citations

Saga of an adventure gene: Novelty Seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism

1997 • 83 citations

EAS temperaments during the last half of the life span: Twins reared apart and twins reared together.

1988 • 80 citations

A population-based twin study of alcoholism in women

1992 • 78 citations

Introduction: Theoretical and Operational Framework for Research into the Etiology of Substance Use Disorders

2001 • 77 citations

Drug abuse: Current concepts and research

1973 • 76 citations

Specific Familial Transmission in Substance Abuse

1988 • 67 citations

Item response theory modeling of substance use: An index based on 10 drug categories.

2002 • 53 citations

An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study.

1998 • 50 citations

Environmental Transmission of DSM‐IV Substance Use Disorders in Adoptive and Step Families

2000 • 42 citations

Drug Abuse: Current Concepts and Research

1973 • 39 citations

The Swedish Studies of the Adopted Children of Alcoholics: A Reply to Littrell

1988 • 37 citations

Antisociality, substance dependence, and theDRD5 gene: A preliminary study

2000 • 34 citations

Substance Abuse in Parents and Their Adolescent Offspring: The Role of Sexual Maturation and Sensation Seeking

2001 • 22 citations

Reconciling unidimensional and multidimensional models of patterns of drug use.

1976 • 17 citations

Association Between the Dopamine Receptor D5 Gene and the Liability to Substance Dependence in Males: A Replication

2001 • 5 citations

Common and specific factors in the familial transmission of substance dependence

2000 • 5 citations

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