Shigella toxin(s) : Description and role in diarrhea and dysentery

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Endocytosis

1977 • 1,275 citations

Iron and infection

1978 • 1,108 citations

EPITHELIAL CELL PENETRATION AS AN ESSENTIAL STEP IN THE PATHOGENESIS OF BACILLARY DYSENTERY

1964 • 628 citations

Cyclic Adenosine Monophosphate and Alteration of Chinese Hamster Ovary Cell Morphology: a Rapid, Sensitive In Vitro Assay for the Enterotoxins of Vibrio cholerae and Escherichia coli

1974 • 572 citations

Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.

1978 • 563 citations

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

1980 • 535 citations

Bacterial toxins and cell membranes

1978 • 471 citations

Iron and infection.

1978 • 464 citations

The effect of intraluminal application of 5‐hydroxytryptamine and 5‐hydroxytryptophan on peristalsis; the local production of 5‐HT and its release in relation to intraluminal pressure and propulsive activity

1958 • 426 citations

The pathogenesis of Shigella Diarrhea

1972 • 311 citations

Cholera

1973 • 294 citations

Ribosome-Membrane Interaction in Eukaryotic Cells

1971 • 278 citations

The children of Santa María Cauqué: a prospective field study of health and growth.

1978 • 249 citations

Pathogenesis of Shigella dysenteriae 1 (Shiga) Dysentery

1973 • 248 citations

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface

1979 • 237 citations

Comparison of Surgery and Prolonged Spironolactone Therapy in Patients with Hypertension, Aldosterone Excess, and Low Plasma Renin

1972 • 178 citations

Pathophysiology of Salmonella diarrhea in the Rhesus monkey: Intestinal transport, morphological and bacteriological studies.

1974 • 178 citations

The Response of Man to Virulent Shigella flexneri 2a

1969 • 176 citations

Epidemic Shiga Bacillus Dysentery in Central America. I. Etiologic Investigations in Guatemala, 1969

1970 • 163 citations

Mechanisms of Intestinal Secretion

1980 • 160 citations

Gastrointestinal motility

1981 • 158 citations

Induction of Steroidogenesis in Tissue Culture by Cholera Enterotoxin

1973 • 142 citations

Diarrhea: A Current View of the Pathophysiology

1972 • 135 citations

Studies in immuno-chemistry

1937 • 120 citations

Studies in immunochemistry

1940 • 119 citations

Abortive Intestinal Infection With anEscherichia coli-Shigella flexneriHybrid Strain

1965 • 113 citations

Extraintestinal manifestations of shigellosis.

1970 • 110 citations

Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro

1966 • 108 citations

Isolation and characterization of Shigella shigae cytotoxin.

1980 • 107 citations

PREPARATION AND PROPERTIES OF SHIGA TOXIN AND TOXOID

1946 • 103 citations

Shigellosis Due to Shigella dysenteriae 1: Relative Importance of Mucosal Invasion versus Toxin Production in Pathogenesis

1972 • 103 citations

Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography

1980 • 96 citations

Pathophysiology of Shigella Diarrhea in the Rhesus Monkey: Intestinal Transport, Morphological, and Bacteriological Studies

1975 • 95 citations

Classification of Enterotoxins on the Basis of Activity in Cell Culture

1975 • 93 citations

Ueber lösliche, durch aseptische Autolyse erhaltene Giftstoffe von Ruhr- und Typhusbazillen

1903 • 91 citations

Siderophore synthesis in Klebsiella pneumoniae and Shigella sonnei during iron deficiency

1979 • 88 citations

PATTERNS OF SEXUALLY TRANSMITTED ENTERIC DISEASES IN A CITY

1977 • 86 citations

Inhibition of protein synthesis in intact HeLa cells by Shigella dysenteriae 1 toxin

1980 • 84 citations

Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin

1977 • 74 citations

Receptor-Mediated Binding and Internalization of Toxins and Hormones

1981 • 73 citations

The Pathogenesis of Shigella Diarrhea. II. Enterotoxin-induced Acute Enteritis in the Rabbit Ileum

1972 • 71 citations

Pathogenesis of shigella diarrhea. VII. Evidence for a cell membrane toxin receptor involving β1 {arrow} 4-linked N-acetyl-D-glucosamine oligomers

1977 • 70 citations

Bacterial Infections of Humans: Epidemiology and Control.

1983 • 70 citations

ACUTE DIARRHOEAL DISEASE IN LESS DEVELOPED COUNTRIES. 2. PATTERNS OF EPIDEMIOLOGICAL BEHAVIOUR IN RURAL GUATEMALAN VILLAGES.

1964 • 70 citations

Inhibition of protein synthesis by Shiga toxin

1980 • 68 citations

SHIGELLOSIS IN CUSTODIAL INSTITUTIONS1

1970 • 68 citations

The Pathogenesis of Shigella Diarrhea. VI. Toxin and Antitoxin in Shigella flexneri and Shigella sonnei Infections in Humans

1977 • 67 citations

Enteric Pathogens in Monkeys

1969 • 66 citations

The Pathogenesis of Shigella Diarrhea. V. Relationship of Shiga Enterotoxin, Neurotoxin, and Cytotoxin

1975 • 66 citations

The role of preschool children and day-care centers in the spread of shigellosis in urban communities

1974 • 63 citations

The neurotoxin of Shigella shigae: morphological and functional lesions produced in the central nervous system of rabbits.

1955 • 62 citations

Quantitative Microassay in Cell Culture for Enterotoxin of Shigella dysenteriae 1

1972 • 61 citations

EXPERIMENTAL SHIGELLA INFECTIONS VI

1963 • 59 citations

Venereal transmission of enteric pathogens in male homosexuals. Two case reports.

1977 • 59 citations

Titration of Cholera Enterotoxin and Antitoxin in Isolated Fat Cells

1970 • 56 citations

Fluorescent-Antibody and Histological Study of Vaccinated and Control Monkeys Challenged with Shigella flexneri

1966 • 54 citations

Effect of Enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae Type 1 on Fluid and Electrolyte Transport in the Colon

1976 • 53 citations

EPIDEMIOLOGY OF COMMON-SOURCE OUTBREAKS OF SHIGELLOSIS IN THE UNITED STATES, 1961–1975

1978 • 53 citations

SHIGELLOSIS IN THE UNITED STATES: FIVE-YEAR REVIEW OF NATIONWIDE SURVEILLANCE, 1964–1968

1970 • 53 citations

The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro.

1960 • 52 citations

TOXINS AND ANTITOXINS OF BACILLUS DYSENTERIÆ SHIGA

1920 • 52 citations

Use of Ligated Segments of Rabbit Small Intestine in Experimental Shigellosis

1965 • 51 citations

Comparison of Secretory and Histological Effects of Shigella and Cholera Enterotoxins in Rabbit Jejunum

1975 • 51 citations

Pathogenesis of shigella diarrhea. Serum anticytotoxin antibody response produced by toxigenic and nontoxigenic Shigella dysenteriae 1.

1976 • 48 citations

Bacteriostatic enterochelin-specific immunoglobulin from normal human serum

1980 • 47 citations

Effect of toxigenic Escherichia coli on myoelectric activity of small intestine.

1978 • 46 citations

Specific Membrane Receptors: Pathogenetic and Therapeutic Implications in Infectious Diseases

1979 • 44 citations

Inhibition of invitro protein synthesis by Shigelladysenteriae 1 toxin

1976 • 44 citations

The neurotoxin of Shigella shigae; a comparative study of the effects produced in various laboratory animals.

1956 • 43 citations

Observations on the intoxication produced in mice and rabbits by the neurotoxin of Shigella shigae.

1955 • 42 citations

Fluid and electrolyte transport in rhesus monkeys challenged intracecally with Shigella flexneri 2a

1976 • 41 citations

Effect of Shigella Enterotoxin on Electrolyte Transport in Rabbit Ileum

1975 • 38 citations

Alteration of myoelectric activity of small intestine by invasive Escherichia coli

1980 • 37 citations

PATHOGENESIS OF BACILLARY DYSENTERY IN LABORATORY ANIMALS.

1965 • 37 citations

The neurotoxin of Shigella shigae. III. The effect of iron on production of the toxin.

1953 • 37 citations

Production and Characterization of Exotoxin(s) of Shigella dysenteriae Type 1

1975 • 37 citations

Shigellosis in nonhuman primates: a review.

1971 • 36 citations

PATHOGENESIS OF SHIGELLA DIARRHEA. III. EFFECTS OF SHIGELLA ENTEROTOXIN IN CELL CULTURE*,†

1973 • 35 citations

Activation of Intestinal Mucosal Adenylate Cyclase by Shigella Dysenteriae I Enterotoxin

1976 • 35 citations

Shigella Infections

1979 • 35 citations

Case of Rheumatoid Lung with Cavity Formation

1963 • 34 citations

Ueber freie Receptoren von Typhus- und Dysenteriebazillen und über das Dysenterietoxin

1903 • 33 citations

THE PATHOGENESIS OF EXPERIMENTAL COLITIS, AND THE RELATION OF COLITIS IN ANIMALS AND MAN

1906 • 33 citations

STUDIES IN THE PATHOGENESIS OF EXPERIMENTAL DYSENTERY INTOXICATION

1960 • 32 citations

Studies of Diarrheal Disease in Central America *

1968 • 32 citations

SHIGELLOSIS IN THE UNITED STATES: TEN-YEAR REVIEW OF NATIONWIDE SURVEILLANCE, 1964–1973

1976 • 31 citations

Serum Enterotoxin-neutralizing Antibody in Human Shigellosis

1973 • 30 citations

Studies of the Acute Diarrheal Diseases: XVIII. Epidemiology

1948 • 28 citations

Cytotoxicity of Shigella dysenteriae 1 for cultured mammalian cells

1980 • 26 citations

Studies of the Acute Diarrheal Diseases XII. Etiology

1945 • 26 citations

Comparison of the Effects of Enterotoxins of Shigella dysenteriae and Vibrio cholerae on the Adenylate Cyclase System of the Rabbit Intestine

1974 • 25 citations

Hygiene Aspects of the El Alamein Victory

1944 • 24 citations

STUDIES OF DIARRHEAL DISEASE IN CENTRAL AMERICA. VI. AN EPIDEMIC OF DIARRHEA IN A GUATEMALAN HIGHLAND VILLAGE, WITH A COMPONENT DUE TO SHIGELLA DYSENTERIAE, TYPE 1.

1965 • 24 citations

PROGRESS OF MEDICAL SCIENCE PREVENTIVE MEDICINE AND EPIDEMIOLOGY UNDER THE CHARGE OF

1964 • 24 citations

Studies in Shigellosis

1955 • 24 citations

Shigellosis and Escherichia coli diarrhea: relative importance of invasive and toxigenic mechanisms

1979 • 22 citations

Ueber die Ruhr als Volkskrankheit und ihren Erreger¹)

1900 • 21 citations

THE NEUROTOXIN OF SHIGELLA DYSENTERIAE (SHIGA)

1952 • 21 citations

Ecological control of the bacterial diarrheas: a scientific strategy

1978 • 19 citations

The Toxic and Antigenic Properties of Fractions Prepared from the Complete Antigen of Shigella Dysenteriae

1948 • 19 citations

RECEPTOR-MEDIATED ENDOCYTOSIS OF SHIGELLA CYTOTOXIN

1981 • 18 citations

Concentration of Serotonin in Intestine and Factors Affecting Its Release

1975 • 18 citations

INFECTION AND DISEASE IN A GROUP OF SOUTH INDIAN FAMILIES: IV: BACTERIOLOGIC METHODS AND A REPORT OF THE FREQUENCY OF ENTERIC BACTERIAL INFECTION IN PRESCHOOL CHILDREN1

1970 • 17 citations

Toxin from the culture filtrate of Shigella dysenteriae that causes morphological changes in Chinese hamster ovary cells and is distinct from the neurotoxin

1977 • 16 citations

From the National Communicable Disease Center

1969 • 16 citations

Studies of Diarrheal Disease in Central America *

1965 • 15 citations

Shigella toxin inhibition of binding and translation of polyuridylic acid by Escherichia coli ribosomes

1980 • 15 citations

Mitomycin C stimulates production of a toxin in Shigella species that causes morphological changes in Chinese hamster ovary cells

1979 • 15 citations

A study on bacteriological lines of the antigens derived from Bact. dysenteriae Shiga and of their antisera in protective tests against the living organisms

1943 • 14 citations

Inhibition of small-intestinal sugar and amino acid transport by the enterotoxin of Shigella dysenteriae I

1977 • 14 citations

SEPARATION OF THE TOXINS OF BACILLUS DYSENTERIÆ SHIGA

1923 • 14 citations

Shigella and Salmonella Diarrhoeal Disease

1979 • 13 citations

STUDIES ON THE TOXIN PRODUCTION OF THE SHIGA BACILLI

1936 • 12 citations

Prevalence of Pathogenic Enteric Bacteria in Children of 31 Panamanian Communities

1971 • 12 citations

Venereal transmission of enteric pathogens in male homosexuals. Two case reports

1977 • 12 citations

STUDY ON TOXINS AND ANTIGENS OF SHIGELLA DYSENTERIAE II

1949 • 10 citations

The Exotoxin of Shigella Dysenteriae

1971 • 10 citations

Bacterial toxins as virulence factors: Shiga bacillus dysentery viewed as a toxinosis.

1977 • 9 citations

Studies with Shigella dysenteriae (Shiga). IV. Immunological reactions in monkeys to the toxins in isolated intestinal pouches.

1953 • 9 citations

TOXINS OF BACT. DYSENTERIAE, GROUP III

1921 • 8 citations

STUDY ON TOXINS AND ANTIGENS OF SHIGELLA DYSENTERIAE I

1949 • 8 citations

STUDIES ON THE EFFECT OF CERTAIN TOXIC SUBSTANCES IN BACTERIAL CULTURES ON THE MOVEMENT OF THE INTESTINES

1926 • 7 citations

PROPHYLACTIC INOCULATION WITH THE O ANTIGEN OF BACT. SHIGÆ

1943 • 7 citations

The Neurotoxin of Shigella shigae. 2. Examination of the Toxin in the Oil-Turbine Ultracentrifuge.

1953 • 6 citations

Differences in Toxicity of the S- and R-Variants of Shigella Dysenteriae

1950 • 6 citations

Production of Potent Toxins by Shigella dysenteriae (Shiga) in a Synthetic Medium

1943 • 5 citations

Action of the Shigella shigae Toxin after Intracerebral Injection

1958 • 5 citations

Das Dysenterietoxin (auf natürlichem Wege gewonnen.)¹)

1904 • 5 citations

Heat-stable enterotoxin produced by Shigella flexneri.

1978 • 4 citations

Studies with Shigella Dysenteriae (Shiga)

1953 • 4 citations

The Preparation of a Potent Toxin of Shigella Dysenteriae (Shiga) on a Semi Synthetic Medium and its Use for the Preparation of an Alum-Precipitated Toxoid

1946 • 4 citations

Toxicity and Antigenic Properties of Different Fractions of B. dysenteriæ (Shiga)

1935 • 4 citations

The neurotoxin of Shigella shigae. IV. A semi-micro method for the flocculation assay of the toxin.

1953 • 4 citations

Studies on the Toxins of Shigella Dysenteriae (Shiga)

1943 • 3 citations

Further Investigations on the Chemistry, Toxicity and other Biological Properties of Different Fractions of Dysentery Bacteria

1937 • 3 citations

Dysentery toxin (Shiga): Notes on its preparation with a discussion of its pasition as an endotoxin

1930 • 3 citations

New and Old Agents in Diarrhea: a Prospective Study of an Indigenous Adult African Population *

1978 • 3 citations

Enteric pathogens in infants and children in Shiraz, Iran: A study of their incidences and infectious drug resistance.

1977 • 3 citations

In vitro inhibition of DNA, RNA, and protein syntheses by Shigella dysenteriae type 1 enterotoxin

1979 • 3 citations

The influence of exotoxin on the blood-brain barrier permeability to inorganic phosphate

1966 • 3 citations

Site of Shigella exotoxin activity in mouse brain

1967 • 3 citations

28 Depletion of catecholamines by shigella shigae toxin in the mouse brain

1961 • 2 citations

The Action of Dysentery Toxins on Different Laboratory Animals.

1946 • 2 citations

The Toxins of B. dysenteriae Shiga.

1922 • 2 citations

Enterotoxin production by Shigella flexneri type 2A, strain no. M42-43.

1978 • 2 citations

Studies with Shigella Dysenteriae (Shiga): I. Infection and Toxin Action in Mice

1948 • 2 citations