Long-term sensitization to the activation of cerebral delta-opioid receptors by the deltorphin Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 in rats exposed to morphine.

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites.

1989 • 453 citations

Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment

1972 • 439 citations

Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

1991 • 412 citations

The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat

1979 • 354 citations

Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for δ opioid receptors

1989 • 227 citations

Neuroanatomical focus for morphine and enkaphalin-induced hypermotility

1977 • 209 citations

Discrete mapping of brain mu and delta opioid receptors using selective peptides: Quantitative autoradiography, species differences and comparison with kappa receptors

1989 • 207 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Conditioning and place-specific sensitization of increases in activity induced by morphine in the VTA

1984 • 181 citations

Stimulant effects of enkephalin microinjection into the dopaminergic A10 area

1979 • 178 citations

Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons.

1987 • 176 citations

Biogenic amines and narcotic effects. I. Modification of morphine-induced analgesia and motor activity after alteration of cerebral amine levels.

1973 • 172 citations

Regulation of Neuropeptide Gene Expression

1990 • 165 citations

Sensitization occurs to the locomotor effects of morphine and the specific μ opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens

1987 • 152 citations

Morphine activation of c-fos expression in rat brain

1988 • 147 citations

The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus

1981 • 137 citations

(D-Ala2)deltorphin II: D1-dependent stereotypies and stimulation of dopamine release in the nucleus accumbens

1991 • 127 citations

Disturbed patterns of behaviour in morphine tolerant and abstinent rats

1971 • 113 citations

Tolerance development to the biphasic effects of morphine on locomotor activity and brain acetylcholine in the rat.

1978 • 113 citations

Persistence of chronic morphine effects upon activity in rats 8 months after ceasing the treatment

1975 • 103 citations

Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine

1989 • 95 citations

Long-term sensitization to the excitatory effects of morphine

1983 • 92 citations

Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective ? and ? opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes

1988 • 87 citations

Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.

1984 • 71 citations

Locomotor activity in morphine-dependent and post-dependent rats

1981 • 69 citations

Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.

1985 • 65 citations

Possible Mechanism of Action of Morphine on Brain

1970 • 63 citations

Opioid δ agonists and endogenous enkephalins induce different emotional reactivity than μ agonists after injection in the rat ventral tegmental area

1991 • 62 citations

Upregulation of the opioid receptor complex by the chronic administration of morphine: A biochemical marker related to the development of tolerance and dependence

1991 • 60 citations

Behavioural effects of deltorphins in rats

1991 • 54 citations

[125I][D-Ala2]deltorphin-I: A high affinity, delta-selective opioid receptor ligand

1991 • 44 citations

Use of μ and δ opioid peptides of various selectivity gives further evidence of specific involvement of μ opioid receptors in supraspinal analgesia (tail-flick test)

1987 • 41 citations

Six novel tachykinin- and bombesin-related peptides from the skin of the Australian frog Pseudophryne güntheri

1990 • 40 citations

Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.

1986 • 39 citations

Effects of β-funaltrexamine (β-FNA) on morphine dependence in rats and monkeys

1986 • 39 citations

Characteristics of μ and δ opioid binding sites in striatal slices of morphine-tolerant and -dependent mice

1991 • 39 citations

MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice

1989 • 38 citations

Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.

1985 • 36 citations

The effects of D-ala2, D-leu5-enkephalin injections into the nucleus accumbens on the motility of rats

1983 • 17 citations