MyoD Functions as a Transcriptional Repressor in Proliferating Myoblasts

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

MyoD or Myf-5 is required for the formation of skeletal muscle

1993 • 1,663 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

1989 • 984 citations

Retention of differentiation potentialities during prolonged cultivation of myogenic cells.

1968 • 975 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

Myogenin gene disruption results in perinatal lethality because of severe muscle defect

1993 • 912 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

1992 • 700 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

1988 • 578 citations

Multiple specific contacts between a mammalian transcription factor and its cognate promoters

1984 • 565 citations

Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

1990 • 508 citations

Clonal Analysis of Myogenesis

1963 • 497 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

1987 • 480 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

Interplay between proliferation and differentiation within the myogenic lineage

1992 • 424 citations

Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase

1995 • 404 citations

Isolation and characterization of human muscle cells.

1981 • 398 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Distinct Regions of Sp1 Modulate DNA Binding and Transcriptional Activation

1988 • 389 citations

Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

1994 • 348 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits.

1990 • 264 citations

Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus.

1995 • 261 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Targets of cyclin-dependent protein kinases

1993 • 240 citations

Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs.

1990 • 199 citations

Embryonic activation of the myoD gene is regulated by a highly conserved distal control element

1995 • 173 citations

Transforming growth factor beta represses the actions of myogenin through a mechanism independent of DNA binding.

1991 • 167 citations

B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits

1991 • 164 citations

Control of mouse myoblast commitment to terminal differentiation by mitogens

1980 • 146 citations

Positive and Negative Regulation of D-type Cyclin Expression in Skeletal Myoblasts by Basic Fibroblast Growth Factor and Transforming Growth Factor β

1995 • 133 citations

Properties of a CCAAT box-binding protein

1987 • 126 citations

Upstream Stimulatory Factor Regulates Expression of the Cell Cycle-Dependent Cyclin B1 Gene Promoter

1995 • 124 citations

Cell Cycle-dependent Regulation of the Cyclin B1 Promoter

1995 • 123 citations

Molecular biology of muscle development

1994 • 105 citations

Modulation of the IgH enhancer's cell type specificity through a genetic switch.

1991 • 104 citations

Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements.

1994 • 100 citations

Evidence that the upstream stimulatory factor and the Sp1 transcription factor bind in vitro to the promoter of the human‐growth‐hormone gene

1989 • 77 citations

Dimerization through the helix-loop-helix motif enhances phosphorylation of the transcription activation domains of myogenin.

1994 • 50 citations