Type 1 von Willebrand disease: application of emerging data to clinical practice

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

2006 • 1,083 citations

The effect of ABO blood group on the diagnosis of von Willebrand disease

1987 • 898 citations

A Revised Classification of von Willebrand Disease

1994 • 595 citations

A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM‐1 VWD)

2006 • 510 citations

Impact, Diagnosis and Treatment of von Willebrand Disease

2000 • 491 citations

ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?

2006 • 407 citations

Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)

2006 • 390 citations

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

2006 • 341 citations

Von Willebrand disease type 1: a diagnosis in search of a disease

2003 • 305 citations

Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival

2006 • 212 citations

Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD

2008 • 198 citations

Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein.

1977 • 184 citations

Mvwf, a Dominant Modifier of Murine von Willebrand Factor, Results from Altered Lineage-Specific Expression of a Glycosyltransferase

1999 • 162 citations

The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors’ Organization

2004 • 162 citations

Reduced von Willebrand factor survival in type Vicenza von Willebrand disease

2002 • 161 citations

An investigation of the von Willebrand factor genotype in UK patients diagnosed to have type 1 von Willebrand disease

2006 • 156 citations

Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM‐1VWD)

2008 • 156 citations

Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor

1996 • 139 citations

von Willebrand disease "Vicenza" with larger-than-normal (supranormal) von Willebrand factor multimers

1988 • 125 citations

Linkage analysis in families diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 VWD

2006 • 116 citations

Inconsistency of Association between Type 1 von Willebrand Disease Phenotype and Genotype in Families Identified in an Epidemiological Investigation

1999 • 106 citations

Cysteine-mutations in von Willebrand factor associated with increased clearance

2005 • 97 citations

Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease

2003 • 92 citations

Genetic linkage and association analysis in type 1 von Willebrand disease: results from the Canadian Type 1 VWD Study

2006 • 81 citations

Dimerization and multimerization defects of von Willebrand factor due to mutated cysteine residues

2004 • 74 citations

Type 1 von Willebrand disease — a clinical retrospective study of the diagnosis, the influence of the ABO blood group and the role of the bleeding history

2000 • 69 citations

Increased clearance of von Willebrand factor antigen post-DDAVP in Type 1 von Willebrand disease: is it a potential pathogenic process?

2003 • 64 citations

Impact of plasma von Willebrand factor levels in the diagnosis of type 1 von Willebrand disease: results from a multicenter European study (MCMDM‐1VWD)

2007 • 62 citations

Challenges in defining type 2M von Willebrand disease: results from a Canadian cohort study

2007 • 50 citations

Identification of Type 2 von Willebrand Disease in Previously Diagnosed Type 1 Patients: a Reappraisal Using Phenotypes, Genotypes and Molecular Modelling

2000 • 48 citations

Response of von Willebrand Factor Parameters to Desmopressin in Patients with Type 1 and Type 2 Congenital von Willebrand Disease: Diagnostic and Therapeutic Implications

2002 • 45 citations

Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: Influence of glycosylation, proteolysis and gene mutations

2008 • 45 citations

von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group

2008 • 44 citations

Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group

2006 • 43 citations

Insights into von Willebrand factor proteolysis: clinical implications

2006 • 43 citations

Significant linkage and non‐linkage of type 1 von Willebrand disease to the von Willebrand factor gene

2001 • 35 citations

Molecular Genetics of Type 2 von Willebrand Disease

2002 • 35 citations

The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co‐segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype

2005 • 31 citations

Genetic analysis of 31 Swedish type 1 von Willebrand disease families reveals incomplete linkage to the von Willebrand factor gene and a high frequency of a certain disease haplotype

2005 • 26 citations

Inherited and de novo von Willebrand disease ‘Vicenza’ in UK families with the R1205H mutation: diagnostic pitfalls and new insights

2006 • 13 citations