Human monocytes lacking the membrane-bound form of the bacterial lipopolysaccharide (LPS) receptor CD14 can mount an LPS-induced oxidative burst response mediated by a soluble form of CD14

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

1993 • 1,033 citations

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

1984 • 973 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

1994 • 747 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.

1993 • 211 citations

The involvement of CD14 in stimulation of cytokine production by uronic acid polymers

1993 • 205 citations

Endotoxin-mediated endothelial cell injury and activation: role of soluble CD14

1993 • 164 citations

Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release.

1995 • 164 citations

Recombinant soluble CD14 inhibits LPS-induced tumor necrosis factor-alpha production by cells in whole blood.

1994 • 152 citations

A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation.

1993 • 151 citations

The two soluble forms of the lipopolysaccharide receptor, CD14: Characterization and release by normal human monocytes

1994 • 147 citations

Enzymatically Deacylated Lipopolysaccharide (LPS) Can Antagonize LPS at Multiple Sites in the LPS Recognition Pathway

1995 • 143 citations

Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells

1994 • 142 citations

Endotoxin-neutralizing capacity of soluble CD14

1992 • 137 citations

The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14.

1995 • 127 citations

Endotoxin activates human vascular smooth muscle cells despite lack of expression of CD14 mRNA or endogenous membrane CD14

1995 • 124 citations

Binding sites for endotoxins (lipopolysaccharides) on human monocytes.

1991 • 113 citations

Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14

1988 • 101 citations

Both membrane‐bound and soluble forms of CD14 bind to Gram‐negative bacteria

1995 • 64 citations

Membrane molecules which trigger the production of interleukin‐1 and tumor necrosis factor‐α by lipopolysaccharide‐stimulated human monocytes

1992 • 63 citations

High level synthesis of immunoglobulins in Chinese hamster ovary cells.

1990 • 59 citations

Impaired phagocyte responses to lipopolysaccharide in paroxysmal nocturnal hemoglobinuria

1993 • 34 citations

The Involvement of CD 14 in Stimulation of TNF Production from Peripheral Mononuclear Cells Isolated from PNH Patients†

1995 • 11 citations

Improved method for preparation of lipopolysaccharide-binding protein from human serum by electrophoretic and chromatographic separation techniques

1994 • 5 citations