Lack of Gender Differences and Large Intrasubject Variability in Cytochrome P450 Activity Measured by Phenotyping with Dextromethorphan
Data up to Jan 2025
Total Citations Per Year
Abstract
References (47)
Goodman & Gilman's The Pharmacological Basis of Therapeutics
1985 • 7,054 citations
Goodman and Gilman's the Pharmacological Basis of Therapeutics
1986 • 6,964 citations
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
1996 • 2,895 citations
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
1997 • 1,161 citations
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*
1996 • 598 citations
Gender Effects in Pharmacokinetics and Pharmacodynamics
1995 • 495 citations
Effect of age and gender on the activity of human hepatic CYP3A
1992 • 425 citations
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin*
1998 • 404 citations
Induction of CYP2D6 in pregnancy*
1997 • 216 citations
Impaired elimination of caffeine by oral contraceptive steroids.
1980 • 177 citations
Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics
1993 • 167 citations
Menstrual cycle effects on caffeine elimination in the human female
1992 • 157 citations
CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans
1993 • 143 citations
DEMOGRAPHIC FACTORS AFFECTING THE PHARMACOKINETICS OF CYCLOSPORINE ESTIMATED BY RADIOIMMUNOASSAY
1986 • 128 citations
Gender differences in human pharmacokinetics and pharmacodynamics
1994 • 119 citations
Intersubject and dose‐related variability after intravenous administration of erythromycin.
1980 • 112 citations
Simultaneous Determination of Dextromethorphan and Three Metabolites in Plasma and Urine Using High-Performance Liquid Chromatography with Application to Their Disposition in Man
1990 • 112 citations
Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam*
1998 • 107 citations
Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics
1984 • 104 citations
Multiple Human Cytochromes Contribute to Biotransformation of Dextromethorphan In-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A
1998 • 100 citations
Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype
1996 • 82 citations
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity
1996 • 81 citations
Metabolism of Dextromethorphanin vitro: Involvement of Cytochromes P450 2D6 AND 3A3/4, with a Possible Role of 2E1
1997 • 81 citations
Inhibition of oral contraceptive steroid—metabolizing enzymes by steroids and drugs
1990 • 79 citations
Effect of age and gender on tirilazad pharmacokinetics in humans
1994 • 75 citations
Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping
1998 • 67 citations
Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation*
1996 • 67 citations
Influence of menstrual cycle and gender on alprazolam pharmacokinetics
1991 • 61 citations
Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity
1996 • 54 citations
Effect of the progestogens, gestodene, 3-keto desogestrel, levonorgestrel, norethisterone and norgestimate on the oxidation of ethinyloestradiol and other substrates by human liver microsomes
1991 • 54 citations
Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics
1990 • 51 citations
Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics*
1996 • 50 citations
Impairment of antipyrine metabolism by low-dose oral contraceptive steroids
1981 • 48 citations
Menstrual Cycle Variability in Midazolam Pharmacokinetics
1999 • 45 citations
Effects of an oral contraceptive on hepatic size and antipyrine metabolism in premenopausal women
1978 • 38 citations
Antipyrine metabolism during the menstrual cycle
1980 • 38 citations
Phenotypic differences in dextromethorphan metabolism.
1989 • 32 citations
Cytochrome P450 3A4 activity in premenopausal and postmenopausal women, based on 6-beta-hydroxycortisol:cortisol ratios.
1998 • 31 citations
Alterations in prednisolone disposition as a result of oral contraceptive use and dose.
1984 • 30 citations
Can oral contraceptive steroids influence the elimination of nifedipine and its primary pryidine metabolite in humans?
1998 • 29 citations
Aging and alfentanil disposition in healthy volunteers and surgical patients
1989 • 24 citations
Cytochrome P450 3A4 Activity in Premenopausal and Postmenopausal Women, Based on 6‐β‐Hydroxycortisol:Cortisol Ratios
1998 • 23 citations
Debrisoquine oxidation in a Finnish population: the effect of oral contraceptives on the metabolic ratio.
1988 • 23 citations
Antipyrine elimination in saliva after low-dose combined or progestogen- only oral contraceptive steroids.
1982 • 16 citations
Effect of steroids on the cytochrome P4502D6-catalysed metabolism of metoprolol
1991 • 11 citations
Urinary excretion of 6β-hydroxycortisol in women during treatment with different oral contraceptive formulations
1995 • 9 citations
Deleted Work
1955 • 0 citations