Scleroderma Fibroblasts Show Increased Responsiveness to Endothelial Cell–Derived IL-1 and bFGF

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

1980 • 4,703 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

IL-1 stimulates IL-6 production in endothelial cells.

1989 • 541 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

Growth factors are released by mechanically wounded endothelial cells.

1989 • 420 citations

Sequential dermal microvascular and perivascular changes in the development of scleroderma

1992 • 386 citations

Significant Correlation Between Connective Tissue Growth Factor Gene Expression and Skin Sclerosis in Tissue Sections from Patients with Systemic Sclerosis

1995 • 278 citations

Endothelin, an endothelial‐dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action

1991 • 228 citations

IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines.

1996 • 219 citations

Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridization

1988 • 207 citations

Variability in Collagen and Fibronectin Synthesis by Scleroderma Fibroblasts in Primary Culture

1981 • 201 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

In situ Expression of Cytokines and Cellular Adhesion Molecules in the Skin of Patients with Systemic Sclerosis

1993 • 155 citations

Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?

1991 • 140 citations

Role of Microvascular Endothelial Cells in Inflammation

1993 • 133 citations

Endothelial cell induced modulation of cardiac fibroblast collagen metabolism

1993 • 82 citations

Expression and Function of Surface Antigens on Scleroderma Fibroblasts

1991 • 79 citations

Progressive systemic sclerosis (PSS, scleroderma) dermal fibroblasts synthesize increased amounts of glycosaminoglycan.

1983 • 71 citations

Control of Fibrosis in Systemic Scleroderma

1993 • 69 citations

Characterization of human umbilical vein endothelial cell lines produced by transfection with the early region of SV40

1992 • 62 citations

IL-1α gene expression and protein production by fibroblasts from patients with systemic sclerosis

1994 • 61 citations

Impaired Regulation of Collagen Pro-∝1(I) mRNA and Change in Pattern of Collagen-Binding Integrins on Scleroderma Fibroblasts

1993 • 60 citations

Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors.

1982 • 53 citations

The endothelium: its role in scleroderma.

1991 • 50 citations

Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function–associated antigen 3 by normal and scleroderma fibroblasts.

1994 • 47 citations

Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three‐dimensional collagen gels

1992 • 42 citations

Increased sensitivity of scleroderma fibroblasts in culture to stimulation of protein and collagen synthesis by serum

1977 • 38 citations

The aetiopathogenesis of systemic sclerosis

1993 • 37 citations

Isolation and characterization of microvascular endothelial cells from the adult human dermis and from skin biopsies of patients with systemic sclerosis.

1994 • 35 citations

Interleukin 1 Receptor on Fibroblasts from Systemic Sclerosis Patients Induces Excessive Functional Responses to Interleukin 1β

1993 • 30 citations

Fibroblast growth factors released by wounded endothelial cells stimulate proliferation of synovial cells.

1992 • 22 citations

Lymphocyte modulation of fibroblast function in systemic sclerosis

1994 • 22 citations

Scleroderma fibroblast phenotype is modulated by endothelial cell co-culture.

1996 • 21 citations

Differential Modulation of bFGF Receptors by TGF-β in Adult Skin, Scleroderma Skin, and Newborn Foreskin Fibroblasts

1992 • 18 citations

Response of scleroderma fibroblasts to various growth factors

1991 • 18 citations

In vitro Cytokine Modulation of Intercellular Adhesion Molecule-1 Expression on Systemic Sclerosis Dermal Fibroblasts

1994 • 17 citations

The Control of Fibrosis in Systemic Sclerosis: A Strategy Involving Extracellular Matrix, Cytokines, and Growth Factors

1994 • 7 citations