Induction of immunogenicity of a human renal-cell carcinoma cell line byTAP1-gene transfer

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

1994 • 356 citations

Ham-2 corrects the class I antigen-processing defect in RMA-S cells

1992 • 289 citations

Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen.

1996 • 285 citations

Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner.

1993 • 266 citations

TAP off - tumors on

1997 • 215 citations

Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells

1994 • 201 citations

Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

1989 • 188 citations

HLA class I antigen and transporter associated with antigen processing (TAP1 and TAP2) down-regulation in high-grade primary breast carcinoma lesions.

1998 • 175 citations

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

1996 • 174 citations

Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes.

1995 • 166 citations

Hla Class I Antigens in Human Tumors

1995 • 133 citations

Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression.

1996 • 123 citations

Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells.

1992 • 115 citations

Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression.

1996 • 92 citations

Combination therapy with interferon alfa-2a and interleukin-2 for the treatment of metastatic cancer.

1995 • 89 citations

Escape from Host-Antitumor Immunity

1997 • 81 citations

Cellular immune response to human renal‐cell carcinomas: Definition of a common antigen recognized by HLA‐A2‐restricted cytotoxic T‐Lymphocyte (CTL) clones

1994 • 64 citations

IFN-gamma-mediated coordinated transcriptional regulation of the human TAP-1 and LMP-2 genes in human renal cell carcinoma.

1997 • 62 citations

Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells

1998 • 28 citations

Tap-1 and Tap-2 Gene Therapy Selectively Restores Conformationally Dependent HLA Class I Expression in Type I Diabetic Cells

1995 • 21 citations

Transfection of TAP 1 gene restores HLA class I expression in human small-cell lung carcinoma

1998 • 21 citations

Cytokine Therapy of Neoplastic and Inflammatory Disease

1993 • 15 citations