Identification of a Novel Receptor Kinase That Phosphorylates a Phospholipase C-linked Muscarinic Receptor

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Muscarinic Receptors—Characterization, coupling and function

1993 • 1,264 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

G protein—coupled receptor kinases

1993 • 434 citations

Inhibition of casein kinase II by heparin.

1980 • 341 citations

Purification and characterization of the beta-adrenergic receptor kinase.

1987 • 241 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.

1987 • 169 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y

1990 • 151 citations

Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.

1994 • 141 citations

Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.

1994 • 132 citations

Multiple pathways of inositol polyphosphate metabolism in angiotensin-stimulated adrenal glomerulosa cells.

1988 • 122 citations

Desensitization of cell signalling mediated by phosphoinositidase C

1993 • 112 citations

Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation

1993 • 110 citations

Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.

1993 • 109 citations

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

1994 • 99 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Muscarinic Receptor‐Mediated Inositol 1,4,5‐Trisphosphate Formation in SH‐SY5Y Neuroblastoma Cells Is Regulated Acutely by Cytosolic Ca²⁺ and by Rapid Desensitization

1994 • 88 citations

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.

1994 • 85 citations

Inhibition of the β-Adrenergic Receptor Kinase by Polyanions

1989 • 83 citations

C-terminal Truncation of the Neurokinin-2 Receptor Causes Enhanced and Sustained Agonist-induced Signaling

1995 • 76 citations

Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.

1995 • 68 citations

Rapid desensitization of muscarinic m3 receptor-stimulated polyphosphoinositide responses.

1992 • 68 citations

Agonist-regulated phosphorylation of the pancreatic cholecystokinin receptor

1991 • 64 citations

Post-translational and Activation-dependent Modifications of the G Protein-coupled Thrombin Receptor

1995 • 63 citations

Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II.

1987 • 57 citations

Rapid agonist mediated phosphorylation of the metabotropic glutamate receptor 1α by protein kinase C in permanently transfected BHK cells

1995 • 57 citations

Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40

1995 • 38 citations

Different modes of regulation for receptors activating phospholipase C in the rat pancreatoma cell line AR4-2J.

1991 • 36 citations

Phosphorylation of a phosphoinositidase C‐linked muscarinic receptor by a novel kinase distinct from β‐adrenergic receptor kinase

1993 • 24 citations

A rapid attenuation of muscarinic agonist stimulated phosphoinositide hydrolysis precedes receptor sequestration in human SH-SY-5Y neuroblastoma cells

1994 • 23 citations

Relationship between agonist binding, phosphorylation and immunoprecipitation of the m₃‐muscarinic receptor, and second messenger responses

1995 • 17 citations

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