Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice

Liver fibrosis – from bench to bedside

2003 • 1,700 citations

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

2003 • 525 citations

Angiotensin II and Renal Fibrosis

2001 • 503 citations

Hepatic Stellate Cells as a Target for the Treatment of Liver Fibrosis

2001 • 492 citations

Angiotensin II induces contraction and proliferation of human hepatic stellate cells

2000 • 489 citations

Host genetic factors influence disease progression in chronic hepatitis C

2000 • 412 citations

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

1999 • 377 citations

Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats

2001 • 373 citations

Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II

2003 • 340 citations

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis

1999 • 325 citations

Angiotensin-Converting Enzyme Inhibition Attenuates the Progression of Rat Hepatic Fibrosis

2001 • 293 citations

Fibrogenic effect of oxidative stress on rat hepatic stellate cells

1998 • 281 citations

Up-regulation of components of the renin-angiotensin system in the bile duct–ligated rat liver

2002 • 186 citations

Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation

1997 • 166 citations

Molecular mechanisms of angiotensin II-induced vascular injury

2003 • 161 citations

Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis

2001 • 157 citations

Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice

1999 • 156 citations

Renal Interstitial Fibrosis Is Reduced in Angiotensin II Type 1a Receptor-Deficient Mice

2001 • 143 citations

Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver

2003 • 138 citations

Vascular and cardiac benefits of angiotensin receptor blockers

2002 • 129 citations

An angiotensin II type 1 receptor antagonist, olmesartan medoxomil, improves experimental liver fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells

2003 • 126 citations

Essential Roles for Angiotensin Receptor AT1a in Bleomycin-Induced Apoptosis and Lung Fibrosis in Mice

2003 • 117 citations

Cultured Myofibroblasts Generate Angiotensin Peptidesde Novo

1997 • 115 citations

Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension

2002 • 114 citations

Renin, aldosterone and renal haemodynamics in cirrhosis with ascites

1979 • 105 citations

The regulatory role of AT1 receptor on activated HSCs in hepatic fibrogenesis: Effects of RAS inhibitors on hepatic fibrosis induced by CCl₄

2000 • 97 citations

Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese

2003 • 94 citations

Angiotensin II, TGF-β and Renal Fibrosis

2001 • 83 citations

Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats

2001 • 78 citations

Effects of AT1 receptor antagonist, losartan, on rat hepatic fibrosis induced by CCl(4).

2000 • 74 citations

AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl4

2003 • 73 citations

Multiple actions of angiotensin II in hypertension

2003 • 66 citations

Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling

2003 • 63 citations

Mechanisms underlying renoprotection during renin-angiotensin system blockade

2001 • 60 citations

Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response

2003 • 58 citations

Effect of losartan, an angiotensin II antagonist, on secondary biliary cirrhosis.

2002 • 55 citations

Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat

2003 • 54 citations

Treatment of diabetic nephropathy with angiotensin II blockers

2003 • 33 citations

Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice

2004 • 29 citations