The release of acetylcholine from the brain: An approach to the study of the central cholinergic mechanisms

Enzymatic Basis for Active Transport of Na⁺ and K⁺ Across Cell Membrane

1965 • 2,008 citations

The release of neural transmitter substances

1969 • 1,134 citations

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

1967 • 1,116 citations

THE CHOLINERGIC LIMBIC SYSTEM: PROJECTIONS TO HIPPOCAMPAL FORMATION, MEDIAL CORTEX, NUCLEI OF THE ASCENDING CHOLINERGIC RETICULAR SYSTEM, AND THE SUBFORNICAL ORGAN AND SUPRA-OPTIC CREST

1967 • 966 citations

Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.

1966 • 809 citations

The release of neural transmitter substances

1970 • 685 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

Choline esters in tissue extracts

1933 • 490 citations

Release of acetylcholine at voluntary motor nerve endings

1936 • 480 citations

Acetylcholine released from cerebral cortex in relation to state of activation

1966 • 432 citations

Acetylcholine Liberation from Cerebral Cortex during Paradoxical (REM) Sleep

1971 • 427 citations

Acetylcholine‐sensitive cells in the cerebral cortex

1963 • 416 citations

The spontaneous and evoked release of acetylcholine from the cerebral cortex

1963 • 386 citations

Synaptic Transmission

2007 • 384 citations

The chemical transmitter at synapses in a sympathetic ganglion

1934 • 279 citations

Dialytrode for long term intracerebral perfusion in awake monkeys.

1972 • 273 citations

The output of sympathetic amines from the cat's adrenal gland in response to splanchnic nerve activity

1961 • 271 citations

The mechanism of acetylcholine release from parasympathetic nerves

1971 • 251 citations

The chemical transmission of secretory impulses to the sweat glands of the cat

1934 • 238 citations

Choline acetylase in the central nervous system of man and some other mammals

1956 • 231 citations

Mesencephalic Reticular Activating System and Cortical Acetylcholine Output

1965 • 225 citations

Cortical acetylcholine release and electroencephalographic arousal

1967 • 218 citations

A histochemical study of cholinergic fibres in the cerebral cortex.

1965 • 198 citations

Depression of Acetylcholine Release from Cerebral Cortical Slices by Cholinesterase Inhibition and by Oxotremorine

1973 • 191 citations

DRUG‐INDUCED CHANGES IN BRAIN ACETYLCHOLINE

1962 • 187 citations

Acetylcholine release from the cerebral cortex: Its role in cortical arousal

1968 • 178 citations

Maintenance of resting membrane potentials in slices of mammalian cerebral cortex and other tissues in vitro

1957 • 171 citations

Physiological Salt Solutions for Brain Surgery

1949 • 169 citations

Choline ester formation in, and choline esterase activities of, tissues in vitro

1936 • 166 citations

Release into the cerebral ventricles of substances with possible transmitter function in the caudate nucleus

1969 • 162 citations

[A new vegetative stabilizer; 4560 R.P..].

1952 • 157 citations

Depression by morphine and chloralose of acetylcholine release from the cat's brain

1965 • 156 citations

Effect of Undercutting on the Acetylcholinesterase and Choline Acetyltransferase Activity in the Cat's Cerebral Cortex

1963 • 142 citations

Actions of dinitrophenol and some other metabolic inhibitors on cortical neurones

1971 • 138 citations

Cholinergic mechanisms in the rat somatosensory cerebral cortex

1972 • 136 citations

Acetylcholine sensitivity of cerebellar neurones in the cat

1966 • 134 citations

THE EFFECT OF TERTIARY AND QUATERNARY ATROPINE ON CORTICAL ACETYLCHOLINE OUTPUT AND ON THE ELECTROENCEPHALOGRAM IN CATS

1964 • 133 citations

The release of acetylcholine and of 3‐hydroxytyramine from the caudate nucleus

1964 • 132 citations

Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the cat

1971 • 126 citations

Effects of ethanol and pentobarbital on release of acetylcholine from cerebral cortex slices.

1967 • 114 citations

EFFECTS OF ANESTHETICS AND CONVULSANTS ON ACETYLCHOLINE CONTENT OF BRAIN

1950 • 112 citations

Effects of nicotine on electrocortical activity and acetylcholine release from the cat cerebral cortex

1969 • 112 citations

ACETYLCHOLINE METABOLISM AT NERVE-ENDINGS

1957 • 109 citations

SYNTHESIS AND STORAGE OF ACETYLCHOLINE IN NERVOUS TISSUE

1963 • 109 citations

CONTROL OF ACETYLCHOLINE SYNTHESIS?THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

1969 • 104 citations

The release of acetylcholine from perfused sympathetic ganglia and skeletal muscles

1956 • 104 citations

Effect of psychoactive drugs on the output of acetylcholine from the cerebral cortex of the cat

1968 • 103 citations

The central release of acetylcholine during consciousness and after brain lesions

1967 • 100 citations

The central release of acetylcholine during stimulation of the visual pathway

1966 • 100 citations

Stimulation by atropine of acetylcholine release and synthesis in cortical slices from rat brain

1970 • 98 citations

THE INFLUENCE OF CENTRALLY ACTING CHOLINOLYTIC DRUGS ON BRAIN ACETYLCHOLINE LEVELS

1964 • 96 citations

Observations bearing on synaptic transmission by acetylcholine in the spinal cord

1941 • 96 citations

The cerebral acetylcholine release in conscious rabbits with semi-permanently implanted epidural cups

1968 • 94 citations

Effects of Morphine and its Antagonists on Release of Cerebral Cortical Acetylcholine

1970 • 92 citations

The influence of atropine on the release and uptake of acetylcholine by the isolated cerebral cortex of the rat

1966 • 92 citations

Biochemistry of simple neuronal models

1970 • 91 citations

The effect of topically applied atropine on resting and evoked cortical acetylcholine release

1969 • 90 citations

Relationship between acetylcholine content and release in the cat's cerebral cortex

1970 • 89 citations

A Pharmacological Approach to the Brain from its Inner and Outer Surface

1964 • 89 citations

Amnesic properties of scopolamine and brain acetylcholine in the rat

1965 • 89 citations

Cholinergic mechanisms in the cerebellar cortex

1968 • 88 citations

PERFUSION OF CEREBRAL VENTRICLES: EFFECTS OF DRUGS ON OUTFLOW FROM THE CISTERNA AND THE AQUEDUCT

1958 • 84 citations

Acetylcholine Release From the Cerebral and Cerebellar Cortices : Its Role in Cortical Arousal

1965 • 84 citations

Central cholinergic pathways.

1969 • 78 citations

Methods for perfusing different parts of the cat's cerebral ventricles with drugs

1964 • 73 citations

The effect of lithium on acetylcholine release and synthesis

1972 • 72 citations

SYNAPTIC TRANSMISSION

1970 • 70 citations

Stimulus-induced Release of Substances from Olfactory Bulb using the Push–Pull Cannula

1968 • 67 citations

The effects of chlorpromazine and ethanol on in vivo release of acetylcholine from the cerebral cortex

1971 • 65 citations

Inhibition by morphine of the release of [14C]acetylcholine from rat brain cortex slices

1969 • 63 citations

Investigations into the release of acetylcholine from the cerebral cortex of the cat: Effects of amphetamine, of scopolamine and of septal lesions

1972 • 59 citations

Effect of Calcium Ions on the Release of Acetylcholine from the Cerebral Cortex

1967 • 58 citations

THE ORIGIN OF THE ACETYLCHOLINE RELEASED FROM THE SURFACE OF THE CORTEX

1972 • 58 citations

The effect of central stimulant drugs on acetylcholine release from rat cerebral cortex

1968 • 57 citations

ACETYLCHOLINE‐SENSITIVITY OF THALAMIC NEURONES: ITS RELATIONSHIP TO SYNAPTIC TRANSMISSION

1968 • 56 citations

Substances with acetylcholine activity in normal rat brain

1962 • 54 citations

The Morphinized–Eserinized Leech Muscle for the Assay of Acetylcholine

1958 • 54 citations

The influence of drugs on the uptake of acetylcholine by slices of rat cerebral cortex

1969 • 52 citations

INFLUENCE OF ANTIMUSCARINIC SUBSTANCES ON IN VITRO SYNTHESIS OF ACETYLCHOLINE BY RAT CEREBRAL CORTEX

1968 • 49 citations

Effect of hyoscine on the output of acetylcholine into perfused cerebral ventricles of cats.

1965 • 49 citations

Effect of angiotensin and atropine on the spontaneous release of acetylcholine from cat cerebral cortex

1970 • 48 citations

DISTRIBUTION OF ACETYLCHOLINE IN THE BRAIN DURING VARIOUS STATES OF ACTIVITY

1963 • 48 citations

A Pharmacological Approach to the Brain from its Inner and Outer Surface.

1963 • 47 citations

Hypercapnia and acetylcholine release from the cerebral cortex and medulla

1966 • 47 citations

INVESTIGATIONS INTO THE ACETYLCHOLINE OUTPUT FROM THE CEREBRAL CORTEX OF THE CAT IN THE PRESENCE OF HYOSCINE

1967 • 47 citations

Brain acetylcholine levels in rats with septal lesions

1971 • 45 citations

The effect of leptazol and strychnine on the acetylcholine release from the cat brain.

1965 • 43 citations

The characteristics of acetylcholine release mechanisms in the auditory cortex

1969 • 43 citations

Changes in the acetylcholine content in the rat brain after lesions of the septum, fimbria and hippocampus

1973 • 42 citations

Zwei neue pharmakologisch aktive Polypeptide in einem Substanz P-haltigen Hirnextrakt

1961 • 42 citations

Chemistry and Brain Development

1971 • 41 citations

Uptake of acetylcholine in rat brain cortex slices

1969 • 41 citations

Assay of Acetylcholine on the Rat Blood Pressure

1958 • 40 citations

MODEL EXPERIMENTS WITH GADDUM'S PUSH-PULL CANNULAS

1967 • 39 citations

CHOLINERGIC TRANSMISSION IN THE FROG SPINAL CORD

1962 • 38 citations

EXPERIMENTS WITH PERFUSED FROG'S SPINAL CORD

1956 • 38 citations

The spontaneous release of 5-hydroxytryptamine and acetylcholine within the diencephalon of the unanaesthetized rhesus monkey

1970 • 38 citations

Effects of some anticholinergic drugs on cortical acetylcholine release and motor activity in rats

1972 • 37 citations

The origin of acetylcholine appearing in the effluent of perfused cerebral ventricles of the cat

1964 • 36 citations

Distribution of acetylcholine in the normal and denervated pigeon ciliary ganglion

1973 • 35 citations

Estimation of the acetylcholine content of rat brain by gas chromatography.

1965 • 34 citations

Effects of various psychotomimetic agents on the eeg and acetylcholine release from the cerebral cortex of brainstem transected cats

1972 • 33 citations

The release of acetylcholine from the spinal cord of the cat by antidromic stimulation of motor nerves

1966 • 33 citations

Nature of Acetylcholine-like Activity released from Brain in vivo

1963 • 33 citations

Relationship between acetylcholine synthesis and its concentration in rat cerebral cortex

1969 • 32 citations

Acetylcholine release from the feline thalamus

1968 • 27 citations

Acetylcholine and 5-hydroxytryptamine levels of the lateral geniculate bodies and superior colliculus of cats after visual deafferentation

1967 • 26 citations

Neurohumoral Mechanisms in the Brain Slice

1971 • 24 citations

Effect of Lithium Ions on the Release of Acetylcholine from the Cerebral Cortex

1971 • 22 citations

THE ABSENCE OF 'SURPLUS' ACETYLCHOLINE FORMATION IN PRISMS PREPARED FROM RAT CEREBRAL CORTEX

1972 • 21 citations

Gas chromatographic evaluation of the effects of some muscarinic and antimuscarinic drugs on acetylcholine levels in rat brain

1970 • 21 citations

The uptake of pentazocine into brain

1971 • 21 citations

The release of acetylcholine and 5-hydroxytryptamine from the mesencephalon of the unanesthetized rhesus monkey

1970 • 21 citations

Identity with authentic acetylcholine of acetycholine-like activity in extracts of rat brain

1963 • 20 citations

INTRACEREBRAL RELEASE OF NEUROHUMORS IN UNANESTHETIZED MONKEYS.

1964 • 18 citations

Chromatographic behaviour of acetylcholine in brain extracts

1963 • 17 citations

Cholinergic neurotransmission in the central nervous system.

1972 • 17 citations

The excitation of central cholinergic mechanisms by stimulation of the auditory pathway

1968 • 16 citations

Scopolamine induced changes of brain acetylcholine and EEG pattern in cats with complete pontine transection.

1966 • 15 citations

Effect of photic stimulation on acetylcholine release from cat cerebral cortex

1972 • 14 citations

Effect of atropine on acetylcholine release from cerebral cortical slices stimulated at different frequencies.

1971 • 12 citations

The Role of Release of Acetylcholine in the Gut-Contracting Action of a Brain Polypeptide

1966 • 11 citations

Validity of a Method measuring Transmitter Release from the Central Nervous System

1968 • 11 citations

Concentration and seasonal variations of acetylcholine in sleep and waking dialysates

1972 • 10 citations

Der Acetylcholingehalt des Gehirns nach Verabreichung von Chloropromazin

1957 • 10 citations

Effect of adrenergic blockers on spontaneous and stimulated acetylcholine output from the cerebral cortex of the cat

1970 • 10 citations

MEASUREMENT OF THE RATE OF ACETYLCHOLINE DIFFUSION THROUGH A BRAIN SLICE AND ITS SIGNIFICANCE IN STUDIES OF THE CELLULAR DISTRIBUTION OF ACETYLCHOLINESTERASE

1971 • 10 citations

Correlation between the Electrical Activity and Acetylcholine Release from the Cerebral Cortex and Medulla during Hypercapnia

1971 • 7 citations

Acetylcholine release into the perfused intermeningeal spaces of the cat spinal cord

1971 • 6 citations

Drugs Interfering with Central Cholinergic Mechanisms

1971 • 6 citations

Confirmation of acetylcholine in perfusates of the stimulated vagus nerve by pyrolysis gas chromatography

1970 • 4 citations

Influence of intracarotid infusions of hexamethonium on acetylcholine release from perfused cerebral ventricles in anaesthetized dogs.

1970 • 4 citations

The Effect of Atropine on the Metabolism of Acetylcholine in the Cerebral Cortex

1972 • 3 citations