Insulin Receptor: Role in the Resistance of Human Obesity to Insulin

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity

1968 • 587 citations

FOREARM METABOLISM IN OBESITY AND ITS RESPONSE TO INTRA-ARTERIAL INSULIN. CHARACTERIZATION OF INSULIN RESISTANCE AND EVIDENCE FOR ADAPTIVE HYPERINSULINISM*

1962 • 499 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

1971 • 443 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULIN

1969 • 381 citations

A procedure for measurement of distribution spaces in isolated fat cells

1972 • 366 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Morphological changes in the adipocyte during fat deposition and mobilization

1967 • 238 citations

Experimental obesity in man.

1968 • 227 citations

Necrosis of the Anterior Pituitary and Zona Glomerulosa of the Adrenal

1964 • 170 citations

Emergence of Insulin Receptors on Human Lymphocytes During In Vitro Transformation

1972 • 153 citations

Lipolysis and lipogenesis from glucose in human fat cells of different sizes

1970 • 146 citations

Insulin Receptors in Human Circulating Lymphocytes: Application to the Study of Insulin Resistance in Man*

1973 • 139 citations

Effect of cell size on lipid synthesis by human adipose tissue in vitro

1971 • 128 citations

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

1972 • 122 citations

Insulin Binding to Isolated Human Adipocytes

1974 • 106 citations

Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance

1973 • 99 citations

Insulin Insensitivity of Large Fat Cells

1972 • 95 citations

Insulin Secretion in Relation to Adipose Tissue in Men

1971 • 91 citations

Glucose Metabolism and the Response to Insulin by Human Adipose Tissue in Spontaneous and Experimental Obesity

1974 • 87 citations

Triglyceride Synthesis in Human Subcutaneous Adipose Tissue Cells of Different Size

1970 • 85 citations

The Composition and Metabolism in Vitro of Adipose Tissue Fat Cells of Different Sizes

1972 • 81 citations

Direct measurements of sugar uptake in small and large adipocytes from young and adult rats

1974 • 78 citations

Lipolytic response and adenyl cyclase activity of rat adipocytes as related to cell size

1971 • 74 citations

Effect of Weight Reduction on in Vitro Adipose Tissue Lipolysis and Cellularity in Obese Adolescents and Adults

1972 • 69 citations

Insulin Receptor of Fat Cells in Insulin-Resistant Metabolic States

1972 • 62 citations

Measurement of Subcutaneous Fat Cells from Obese Patients

1970 • 61 citations

Studies on Adipose Tissue from Obese Patients with or without Diabetes Mellitus

1966 • 58 citations

Speculations on the Action of Insulin, With a Note on Other Hypoglycemic Agents

1957 • 44 citations

Regulation of Rat Hexokinase Isoenzymes: I. Assay and Effect of Age, Fasting and Refeeding

1973 • 37 citations

Effect of Obesity on Insulin Sensitivity of Human Adipose Tissue

1972 • 26 citations

Glucose Metabolism and Responsiveness to Bovine Insulin by Adipose Tissue from Three Mammalian Species

1972 • 17 citations