Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage

Evidence for Early Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS) and Other Human Immunodeficiency Virus (HIV) Infections

1987 • 573 citations

Dendritic injury is a pathological substrate for human immunodeficiency virus—related cognitive disorders

1997 • 470 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood‐brain barrier

1993 • 333 citations

Clinical‐neuropathologic correlation in HIV‐associated dementia

1993 • 325 citations

HIV‐Associated Disease of the Nervous System: Review of Nomenclature and Proposal for Neuropathology‐Based Terminology

1991 • 323 citations

Brain pathology induced by infection with the human immunodeficiency virus (HIV)

1987 • 315 citations

Evidence of apoptotic cell death in HIV encephalitis.

1995 • 297 citations

Blood‐brain barrier abnormalities in acquired immunodeficiency syndrome: Immunohistochemical localization of serum proteins in postmortem brain

1992 • 275 citations

Neuropathology of Early HIV‐1 Infection

1996 • 263 citations

Distribution of Brain HIV Load in AIDS

1998 • 252 citations

Neuronal apoptosis in HIV infection in adults

1995 • 244 citations

Apoptosis induced by HIV-1 infection of the central nervous system.

1996 • 230 citations

Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

1994 • 230 citations

Delayed Transneuronal Death of Substantia Nigra Neurons Prevented by γ-Aminobutyric Acid Agonist

1987 • 221 citations

Apoptotic neurons in brains from paediatric patients with HIV‐I encephalitis and progressive encephalopathy

1995 • 220 citations

Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia

1998 • 189 citations

Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS.

1998 • 175 citations

A Review of Neuronal Damage in Human Immunodeficiency Virus Infection

1993 • 169 citations

Early Brain Changes in HIV Infection

1992 • 167 citations

Quantitation of human immunodeficiency virus in brains of demented and nondemented patients with acquired immunodeficiency syndrome

1996 • 120 citations

Accumulation of β‐amyloid precursor protein in HIV encephalitis: Relationship with neuropsychological abnormalities

1997 • 112 citations

Axotomy-induced apoptosis in adult rat primary sensory neurons.

1997 • 100 citations

Immunohistochemical Changes and PCR Detection of HIV Provirus DNA in Brains of Asymptomatic HIV-Positive Patients

1994 • 94 citations

HIV‐1‐associated cognitive/motor complex

1993 • 92 citations

Axonal Damage Revealed by Accumulation of β-APP in HIV-positive Individuals without AIDS

1997 • 90 citations

Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study

1993 • 88 citations

Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia

1994 • 85 citations

Cerebral white matter damage in HIV infection demonstrated using β-amyloid precursor protein immunoreactivity

1997 • 80 citations

Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patients

1996 • 70 citations

AIDS Dementia Complex and HIV‐1 Infection: A View From the Clinic

1991 • 68 citations

Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy

1991 • 67 citations

Investigation on the expression of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1-positive patients

1996 • 59 citations

Effect of Postmortem Interval on In Situ End-Labeling of DNA Oligonucleosomes

1995 • 57 citations

The effects of formalin fixation on the detection of apoptosis in human brain by in situ end-labelling of DNA

1995 • 48 citations

Multifocal necrotizing leukoencephalopathy with pontine predilection in immunosuppressed patients: A clinicopathologic review of 16 cases

1993 • 43 citations

Assessment of neuronal density in the putamen in human immunodeficiency virus (HIV) infection. Application of stereology and spatial analysis of quadrats

1995 • 42 citations

Human immunodeficiency virus type 1 DNA and RNA load in brains of demented and nondemented patients with acquired immunodeficiency syndrome

1997 • 33 citations

Acute, relapsing brain oedema with diffuse blood–brain barrier alteration and axonal damage in the acquired immunodeficiency syndrome

1998 • 31 citations

DNA breaks detected by in situ end‐labelling in dorsal root ganglia of patients with AIDS

1998 • 27 citations

[Early cerebral lesions in HIV infection. Postmortem radio-pathologic correlations in non-AIDS asymptomatic seropositive patients].

1995 • 12 citations

The effects of formalin fixation on the detection of apoptosis in human brain byin situ end-labelling of DNA

1995 • 2 citations

New mechanisms of neurodegeneration in HIV encephalitis: microglial associated neurotrophic dysfunction

1998 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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