The biochemistry of the renin-angiotensin system and its role in hypertension

STUDIES ON EXPERIMENTAL HYPERTENSION

1934 • 2,092 citations

THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

1956 • 994 citations

Niere und Kreislauf¹

1898 • 761 citations

Angiotensin I converting enzyme.

1975 • 566 citations

Conversion of Angiotensin I to Angiotensin II

1967 • 526 citations

Hypotensive Agents and Pressor Substances

1960 • 523 citations

Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom

1971 • 480 citations

A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR

1940 • 427 citations

THE EXISTENCE OF TWO FORMS OF HYPERTENSIN

1954 • 426 citations

Concentrations of angiotensin-converting enzyme in tissues of the rat

1971 • 415 citations

The substance causing renal hypertension

1940 • 360 citations

Hypertension of Renal Origin: Evidence for Two Different Mechanisms

1971 • 338 citations

THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE

1957 • 320 citations

Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II)

1975 • 300 citations

Role of the Pressor Action of Angiotensin IIin Experimental Hypertension

1971 • 297 citations

Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats

1973 • 288 citations

THE RENAL ORIGIN OF HYPERTENSION

1947 • 270 citations

Pulmonary angiotensin-converting enzyme. Structural and catalytic properties.

1975 • 263 citations

Hydrolysis of Bradykinin by Angiotensin-Converting Enzyme

1974 • 221 citations

Isolation and characterization of renin-like enzymes from mouse submaxillary glands

1972 • 215 citations

THE DISAPPEARANCE OF BRADYKININ AND ELEDOISIN IN THE CIRCULATION AND VASCULAR BEDS OF THE CAT

1967 • 212 citations

Angiotensins I and II, active and inactive renin, renin substrate, renin activity, and angiotensinase in human liquor amnii and plasma

1975 • 201 citations

Activation of renin in human amniotic fluid by low pH.

1971 • 197 citations

THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN THE CONTROL OF ALDOSTERONE SECRETION*

1962 • 191 citations

THE EFFECTS OF INTRAVENOUS INFUSIONS OF VALINE-5 ANGIOTENSIN II AND OTHER PRESSOR AGENTS ON URINARY ELECTROLYTES AND CORTICOSTEROIDS, INCLUDING ALDOSTERONE*

1961 • 182 citations

THE EFFECT OF THE HEPTAPEPTIDE (2-8) AND HEXAPEPTIDE (3-8) FRAGMENTS OF ANGIOTENSIN II ON ALDOSTERONE SECRETION¹

1971 • 169 citations

THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS

1964 • 159 citations

Synthesis of a Biologically Active Octapeptide Similar to Natural Isoleucine Angiotonin Octapeptide¹

1957 • 150 citations

Synthesis and Pharmacology of the Octapeptide Angiotonin

1957 • 146 citations

THE AMINO ACID COMPOSITION OF HYPERTENSIN II AND ITS BIOCHEMICAL RELATIONSHIP TO HYPERTENSIN I

1956 • 143 citations

The activation of renin in human amniotic fluid by proteolytic enzymes

1972 • 142 citations

Occurrence of Big Renin in Human Plasma, Amniotic Fluid and Kidney Extracts

1975 • 141 citations

THE PURIFICATION OF HYPERTENSIN I

1954 • 137 citations

KINETICS OF THE REACTION OF RENIN WITH NINE SYNTHETIC PEPTIDE SUBSTRATES

1968 • 136 citations

Synthese eines hochwirksamen Hypertensin II‐amids (<scp>L</scp>‐Asparaginyl‐<scp>L</scp>‐arginyl‐<scp>L</scp>‐valyl‐<scp>L</scp>‐tyrosyl‐<scp>L</scp>‐isoleucyl‐<scp>L</scp>‐histidyl‐<scp>L</scp>‐prolyl‐<scp>L</scp>‐phenylalanin)

1957 • 132 citations

Isolation of pure and stable renin from hog kidney

1975 • 127 citations

Inhibition of Angiotensin Conversion in Experimental Renovascular Hypertension

1972 • 127 citations

Increased Renin Activity after Cold Storage of Human Plasma

1973 • 124 citations

A Protein-Bound Form of Porcine Renal Renin

1974 • 122 citations

Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.

1975 • 118 citations

POTENTIAL SCREENING TEST FOR DETECTION OF OVERACTIVITY OF RENIN-ANGIOTENSIN SYSTEM

1971 • 112 citations

Angiotensin II- and Angiotensin III-Induced Aldosterone Release in vivo in the Rat

1974 • 108 citations

BIG RENIN: A POSSIBLE PROHORMONE IN KIDNEY AND PLASMA OF A PATIENT WITH WILMS' TUMOR¹

1974 • 108 citations

THE ASSAY OF HYPERTENSIN FROM THE ARTERIAL BLOOD OF NORMOTENSIVE AND HYPERTENSIVE HUMAN BEINGS

1952 • 108 citations

PRODUCTION OF ANTIRENIN TO HOMOLOGOUS RENIN AND ITS EFFECT ON EXPERIMENTAL RENAL HYPERTENSION

1964 • 106 citations

A renin inhibitor from rabbit kidney: conversion of a large inactive renin to a smaller active enzyme.

1975 • 101 citations

THE PURIFICATION AND PARTIAL CHARACTERIZATION OF SEVERAL FORMS OF HOG RENIN SUBSTRATE

1963 • 101 citations

Some Properties of Angiotensin Converting Enzyme in the Lung in vivo

1970 • 101 citations

Antibodies to Renin as Proof of the Pathogenesis of Sustained Renal Hypertension

1958 • 99 citations

Converting enzyme content of different tissues of the rat

1969 • 98 citations

Differentiation Between Two Forms of Angiotonin by Means of Spirally Cut Strips of Rabbit Aorta

1957 • 96 citations

Pseudorenin: A NEW ANGIOTENSIN-FORMING ENZYME

1969 • 93 citations

Biochemical Properties of Big Renin Extracted from Human Plasma

1975 • 88 citations

Isolation and purification of hog renin

1953 • 87 citations

Renal-Clip Hypertension in Rabbits Immunized Against Angiotensin II

1970 • 86 citations

"Prorenin" in human plasma?

1975 • 83 citations

Synthesis of some analogs of angiotensin II as specific antagonists of the parent hormone

1972 • 76 citations

Studies on angiotensinogen formation in a liver perfusion system.

1972 • 75 citations

THE SYNTHESIS OF A TETRADECAPEPTIDE RENIN SUBSTRATE

1958 • 74 citations

Angiotensin-Converting Enzyme from Rabbit Pulmonary Particles

1974 • 72 citations

The isolation of a hypertensin

1956 • 72 citations

The Activation of a Possible Zymogen of Renin in Rabbit Kidney

1973 • 66 citations

Purification of Hog Renin. Properties of Purified Hog Renin

1972 • 65 citations

Studies on Renin Antibodies

1958 • 64 citations

Effects of the Nonapeptide SQ 20881 on Blood Pressure of Rats with Experimental Renovascular Hypertension

1973 • 64 citations

Studies on the role of angiotensin in experimental renovascular hypertension: an immunologic approach

1969 • 61 citations

Role of the Renin-Angiotensin System In the Pathogenesis of Severe Hypertension in Rats

1971 • 61 citations

THE NATURE OF RENIN ACTIVATOR

1943 • 60 citations

THE ORIGIN OF RENIN-ACTIVATOR

1941 • 57 citations

AMINO ACID COMPOSITION AND ELECTROPHORETIC PROPERTIES OF HYPERTENSIN I

1955 • 54 citations

Studies on the preparation and properties of renin.

1967 • 49 citations

Renal Hypertension in Rabbits Immunized with Angiotensin - II

1970 • 44 citations

Des-1-Asp-angiotensin II. Possible intrarenal role in homeostasis in the dog.

1975 • 44 citations

Biological significance of renin angiotensin immunization.

1970 • 44 citations

The Isolation of Hypertensin from the Circulating Blood of Normal Dogs with Experimental Renal Hypertension by Dialysis in an Artificial Kidney

1951 • 43 citations

Pepstatin Inhibition of Human Renin

1974 • 42 citations

Isolation and amino acid composition of human angiotensin I

1967 • 41 citations

Treatment and prophylaxis of experimental renal hypertension with renin.

1953 • 40 citations

Converting Enzyme in Vitro Measurement and Properties

1974 • 38 citations

Renin in Experimental Renal Hypertension in Monkeys

1963 • 34 citations

Renovascular Hypertension in Rats Immunized with Angiotensin II

1972 • 34 citations

THE PURIFICATION OF HOG RENIN SUBSTRATE

1954 • 31 citations

Studies on the partial isolation of human renin

1970 • 30 citations

Partial purification of a high molecular weight renin from hog kidney.

1976 • 29 citations

ROLE OF THE RENIN‐SYSTEM IN NORMO‐ AND HYPERTENSION

1973 • 28 citations

The Fate of Angiotensin I

1974 • 26 citations

Role of angiotensin II in experimental renal hypertension in the rabbit

1975 • 25 citations

Chronic one-kidney hypertension in rabbits. I. Treatment with kidney extracts.

1975 • 23 citations

The effect of intravenous antirenin injection on chronic experimental and acute renin-induced hypertension in dogs.

1970 • 23 citations

Purification of human renin.

1970 • 22 citations

Purification of hog renin by affinity chromatography using the synthetic competitive inhibitor [d-Leu6]octapeptide

1975 • 22 citations

Renin and Antirenin in Treatment of Long Term Experimental Renal Hypertension in the Dog.

1955 • 21 citations

Partial Separation of an Oxytocic Principle from Preparations of Angiotonin

1956 • 19 citations

The Role of the Renin-Angiotensin System in Experimental Renal Hypertension in Dogs

1974 • 18 citations

Effects of ganglionic blocking agents, pressor and depressor drugs on renal hypertension

1959 • 17 citations

On the structure of renin substrate

1971 • 15 citations

Multiple Forms of Human Kidney Renin

1972 • 12 citations

Immunogenicity and Antigenicity of Angiotensin I and II

1974 • 10 citations

Deleted Work

1955 • 0 citations