Thrombotic thrombocytopenic purpura: recognition and management

Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis

2004 • 2,504 citations

Comparison of Plasma Exchange with Plasma Infusion in the Treatment of Thrombotic Thrombocytopenic Purpura

1991 • 1,836 citations

Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura

1998 • 1,749 citations

von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome

1998 • 1,630 citations

Improved Survival in Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome

1991 • 838 citations

ADAMTS13 activity in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients

2003 • 675 citations

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

2008 • 565 citations

Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura

2001 • 553 citations

From the bench to the bedside: ways to improve rituximab efficacy

2004 • 527 citations

Thrombotic Thrombocytopenic Purpura

2006 • 456 citations

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura

2004 • 445 citations

Blood and Marrow Transplant Clinical Trials Network Toxicity Committee Consensus Summary: Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation

2005 • 440 citations

Specific von Willebrand factor–cleaving protease in thrombotic microangiopathies: a study of 111 cases

2001 • 391 citations

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

2003 • 382 citations

Regional UK TTP Registry: correlation with laboratory ADAMTS 13 analysis and clinical features

2008 • 350 citations

ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases

2005 • 298 citations

Prognostic value of anti-ADAMTS13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS13 activity

2006 • 277 citations

Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases

2005 • 273 citations

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

2008 • 259 citations

Nonneutralizing IgM and IgG antibodies to von Willebrand factor–cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura

2003 • 221 citations

Severe ADAMTS13 Deficiency in Adult Idiopathic Thrombotic Microangiopathies Defines a Subset of Patients Characterized by Various Autoimmune Manifestations, Lower Platelet Count, and Mild Renal Involvement

2004 • 197 citations

Advances in the Pathogenesis, Diagnosis, and Treatment of Thrombotic Thrombocytopenic Purpura

2003 • 188 citations

Quinine-Associated Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome: Frequency, Clinical Features, and Long-Term Outcomes

2001 • 162 citations

High incidence of relapses in thrombotic thrombocytopenic purpura

1987 • 160 citations

United States thrombotic thrombocytopenic purpura apheresis study group (US TTP ASG): Multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange

1998 • 158 citations

Management Of Thrombotic Thrombocytopenic Purpura

2000 • 158 citations

von Willebrand factor cleaving protease (ADAMTS‐13) and ADAMTS‐13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura

2004 • 154 citations

Predicting response to plasma exchange in patients with thrombotic thrombocytopenic purpura with measurement of vWF‐cleaving protease activity

2002 • 139 citations

Cryoprecipitate poor plasma does not improve early response in primary adult thrombotic thrombocytopenic purpura (TTP)

2001 • 133 citations

Drug-Induced Thrombotic Microangiopathy

2005 • 133 citations

Disseminated Malignancy Misdiagnosed as Thrombotic Thrombocytopenic Purpura: A Report of 10 Patients and a Systematic Review of Published Cases

2007 • 130 citations

Cellular source of serum lactate dehydrogenase elevation in patients with thrombotic thrombocytopenic purpura

1998 • 124 citations

Rituximab Therapy for Refractory Thrombotic Thrombocytopenic Purpura

2002 • 121 citations

Rituximab for chronic recurring thrombotic thrombocytopenic purpura: a case report and review of the literature

2004 • 121 citations

Prognostic value of inhibitory anti‐ADAMTS13 antibodies in adult‐acquired thrombotic thrombocytopenic purpura

2005 • 115 citations

The Japanese experience with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome

2004 • 113 citations

Rituximab therapy for thrombotic thrombocytopenic purpura: A proposed study of the Transfusion Medicine/Hemostasis Clinical Trials Network with a systematic review of rituximab therapy for immune‐mediated disorders

2006 • 113 citations

Antiplatelet agents in thrombotic thrombocytopenic purpura (TTP). Results of a randomized multicenter trial by the Italian Cooperative Group for TTP.

1997 • 110 citations

ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor‐cleaving protease activity by recombinant human ADAMTS13

2003 • 104 citations

HIV‐Associated Thrombotic Microangiopathy in the Era of Highly Active Antiretroviral Therapy: An Observational Study

2004 • 99 citations

Splenectomy Done during Hematologic Remission To Prevent Relapse in Patients with Thrombotic Thrombocytopenic Purpura

1996 • 98 citations

A randomized, controlled Phase III trial of therapeutic plasma exchange with fresh‐frozen plasma (FFP) prepared with amotosalen and ultraviolet A light compared to untreated FFP in thrombotic thrombocytopenic purpura

2006 • 95 citations

Severe deficiency of VWF‐cleaving protease (ADAMTS13) activity defines a distinct population of thrombotic microangiopathy patients

2004 • 90 citations

The course of ADAMTS‐13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine

2005 • 90 citations

Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura

2003 • 89 citations

Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies

2009 • 88 citations

Response to plasma exchange and splenectomy in thrombotic thrombocytopenic purpura. A 10-year experience at a single institution.

1992 • 84 citations

Cancer Awareness in Atypical Thrombotic Microangiopathies

2009 • 84 citations

An evaluation of ciclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpura

2006 • 75 citations

Two Mechanistic Pathways for Thienopyridine-Associated Thrombotic Thrombocytopenic Purpura

2007 • 75 citations

Identification of novel mutations in ADAMTS13 in an adult patient with congenital thrombotic thrombocytopenic purpura

2004 • 73 citations

Thrombotic thrombocytopenic purpura in patients with retroviral infection is highly responsive to plasma infusion therapy

2005 • 72 citations

Thrombotic Microangiopathies: Towards a Pathophysiology-Based Classification

2009 • 70 citations

Combination vincristine and plasma exchange as initial therapy in patients with thrombotic thrombocytopenic purpura: one institution's experience and review of the literature

2004 • 69 citations

Comparison and stability of ADAMTS13 activity in therapeutic plasma products

2006 • 66 citations

Response to Plasma Exchange and Splenectomy in Thrombotic Thrombocytopenic Purpura

1992 • 63 citations

TTP and ADAMTS13: When Is Testing Appropriate?

2007 • 62 citations

Adult hemolytic-uremic syndrome

1980 • 60 citations

Treatment of thrombotic thrombocytopenic purpura

2006 • 59 citations

Sporadic bloody diarrhoea‐associated thrombotic thrombocytopenic purpura‐haemolytic uraemic syndrome: an adult and paediatric comparison

2008 • 57 citations

Cardiogenic shock complicates successful treatment of refractory thrombotic thrombocytopenia purpura with rituximab

2005 • 49 citations

Thrombotic Microangiopathy in Transplantation and Malignancy

2005 • 45 citations

Lessons learned from the Oklahoma Thrombotic Thrombocytopenic Purpura‐Hemolytic Uremic Syndrome Registry

2008 • 44 citations

[Treatment of thrombotic thrombopenic purpura. Results of a multicenter randomized clinical study].

1991 • 42 citations

Adult Hemolytic-Uremic Syndrome

1995 • 39 citations

Vincristine as salvage treatment for refractory thrombotic thrombocytopenic purpura

1999 • 36 citations

Management of a patient with HIV infection‐induced anemia and thrombocytopenia who presented with thrombotic thrombocytopenic purpura

2002 • 31 citations

The Management of Thrombotic Thrombocytopenic Purpura in 2005

2005 • 31 citations

Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy

2009 • 25 citations

Frequency and significance of schistocytes in TTP/HUS patients at the discontinuation of plasma exchange therapy

2004 • 23 citations

A Canadian phase II study evaluating the efficacy of rituximab in the management of patients with relapsed/refractory thrombotic thrombocytopenic purpura

2009 • 23 citations

Patterns of Platelet Response in Idiopathic TTP/HUS: Frequency of Declining Platelet Counts With Plasma Exchange and the Recognition and Significance of a Pseudo Refractory State

2006 • 6 citations

Selective inactivation of Von Willebrand factor binding to glycoprotein IIb/IIIa and to inhibitor monoclonal antibody 9 by site-directed mutagenesis

2001 • 6 citations