Construction of Skin Equivalents for Gene Therapy of Recessive Dystrophic Epidermolysis Bullosa

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

1999 • 2,179 citations

p63 identifies keratinocyte stem cells

2001 • 1,339 citations

Three clonal types of keratinocyte with different capacities for multiplication.

1987 • 1,271 citations

Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma

1975 • 1,113 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Revised classification system for inherited epidermolysis bullosa

2000 • 399 citations

THE CONTROL OF EPIDERMAL STEM CELLS (HOLOCLONES) IN THE TREATMENT OF MASSIVE FULL-THICKNESS BURNS WITH AUTOLOGOUS KERATINOCYTES CULTURED ON FIBRIN1

1999 • 356 citations

LONG-TERM REGENERATION OF HUMAN EPIDERMIS ON THIRD DEGREE BURNS TRANSPLANTED WITH AUTOLOGOUS CULTURED EPITHELIUM GROWN ON A FIBRIN MATRIX1,2

2000 • 335 citations

Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa

1993 • 266 citations

Multicentre experience in the treatment of burns with autologous and allogenic cultured epithelium, fresh or preserved in a frozen state

1989 • 257 citations

Stable nonviral genetic correction of inherited human skin disease

2002 • 249 citations

Development of lentiviral vectors for gene therapy for human diseases

2000 • 241 citations

Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy.

1996 • 227 citations

A missense mutation in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa

1993 • 199 citations

Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa

2002 • 195 citations

Evidence for keratinocyte stem cells in vitro : Long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes

1998 • 192 citations

Clonal analysis of stably transduced human epidermal stem cells in culture.

1996 • 163 citations

Characterization of 18 New Mutations in COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Provides Evidence for Distinct Molecular Mechanisms Underlying Defective Anchoring Fibril Formation

1997 • 159 citations

Monoclonal antibody GB3 defines a widespread defect of several basement membranes and a keratinocyte dysfunction in patients with lethal junctional epidermolysis bullosa.

1991 • 157 citations

Epidermolysis bullosa and cancer

2002 • 155 citations

Two Forms of Collagen XVII in Keratinocytes

1998 • 152 citations

Extensive tissue-regenerative capacity of neonatal human keratinocyte stem cells and their progeny

2004 • 151 citations

Extensive tissue-regenerative capacity of neonatal human keratinocyte stem cells and their progeny

2004 • 151 citations

A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors

2001 • 149 citations

Immunohistochemical and mutation analyses demonstrate that procollagen VII is processed to collagen VII through removal of the NC-2 domain.

1995 • 140 citations

EVIDENCE THAT HUMAN ORAL EPITHELIUM RECONSTITUTED IN VITRO AND TRANSPLANTED ONTO PATIENTS WITH DEFECTS IN THE ORAL MUCOSA RETAINS PROPERTIES OF THE ORIGINAL DONOR SITE1

1990 • 134 citations

Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue

2003 • 132 citations

Corrective Transduction of Human Epidermal Stem Cells in Laminin-5-Dependent Junctional Epidermolysis Bullosa

1998 • 124 citations

Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue

2003 • 121 citations

Fresh versus cryopreserved cultured allografts for the treatment of chronic skin ulcers

1990 • 115 citations

Treatment of Posterior Hypospadias by the Autologous Graft of Cultured Urethral Epithelium

1990 • 112 citations

Biology of anchoring fibrils: lessons from dystrophic epidermolysis bullosa

1999 • 104 citations

New Techniques for the Grafting of Cultured Human Epidermal Cells onto Athymic Animals

1988 • 100 citations

A Preclinical Model for the Analysis of Genetically Modified Human SkinIn Vivo

2002 • 98 citations

The LG3 Module of Laminin-5 Harbors a Binding Site for Integrin α3β1 That Promotes Cell Adhesion, Spreading, and Migration

2001 • 98 citations

Revised classification system for inherited epidermolysis bullosa: Report of the Second International Consensus Meeting on diagnosis and classification of epidermolysis bullosa

2000 • 88 citations

Corrective gene transfer of keratinocytes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia

1998 • 87 citations

Genetic correction of canine dystrophic epidermolysis bullosa mediated by retroviral vectors

2003 • 87 citations

Collagen fibril network and elastic system remodeling in a reconstructed skin transplanted on nude mice

2001 • 87 citations

Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skininvitro

2001 • 79 citations

Genetic Basis of Dominantly Inherited Transient Bullous Dermolysis of the Newborn: A Splice Site Mutation in the Type VII Collagen Gene

1997 • 70 citations

Quantitative Protein Precipitation from Guanidine Hydrochloride-Containing Solutions by Sodium Deoxycholate/Trichloroacetic Acid

1999 • 59 citations

A Microinjected COL7A1-PAC Vector Restores Synthesis of Intact Procollagen VII in a Dystrophic Epidermolysis Bullosa Keratinocyte Cell Line

2002 • 56 citations

Toward Epidermal Stem Cell-Mediatedex VivoGene Therapy of Junctional Epidermolysis Bullosa

2000 • 52 citations

Expression of Rho GTPases using retroviral vectors

2000 • 49 citations

Replication of Lengthened Moloney Murine Leukemia Virus Genomes Is Impaired at Multiple Stages

2000 • 43 citations

Assessment of optimal transduction of primary human skin keratinocytes by viral vectors

2005 • 28 citations

Proteolytic Processing of the Laminin α3 G Domain Mediates Assembly of Hemidesmosomes but Has No Role on Keratinocyte Migration

2005 • 27 citations

Hemidesmosome assembly assessed by expression of a wild-type integrin beta 4 cDNA in junctional epidermolysis bullosa keratinocytes.

1997 • 24 citations

HIV-based vectors: getting the best out of the worst

2000 • 10 citations

The Virtue of Tolerance

2003 • 2 citations