Systemic Lupus Erythematosus: Insights from Animal Models

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1979 • 907 citations

Etiopathogenesis of Murine SLE¹

1981 • 517 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

1982 • 421 citations

In situ immune complex formation and glomerular injury

1980 • 378 citations

Role of nutrition in immunologic function.

1980 • 375 citations

Mode of Inheritance of Decreased C3b Receptors on Erythrocytes of Patients with Systemic Lupus Erythematosus

1982 • 334 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

Dietary enrichment with the polyunsaturated fatty acid eicosapentaenoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice.

1981 • 328 citations

B-Lymphocyte Alloantigens Associated with Systemic Lupus Erythematosus

1978 • 293 citations

Autoimmunity - A Perspective

1983 • 260 citations

Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene.

1981 • 237 citations

Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus.

1978 • 236 citations

STUDIES IN FAMILIAL SYSTEMIC LUPUS ERYTHEMATOSUS

1976 • 233 citations

X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.

1975 • 200 citations

Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: inhibitory effect of endotoxin.

1982 • 193 citations

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

1983 • 188 citations

Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus.

1980 • 167 citations

Influence of dietary restriction on immunologic function and renal disease in (NZB × NZW) F ₁ mice

1978 • 167 citations

Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis

1982 • 162 citations

Effects of dietary enrichment with eicosapentaenoic acid upon autoimmune nephritis in female NZBXNZW/F₁ MICE

1983 • 159 citations

Immunoglobulin G Fc Receptor-Mediated Clearance in Autoimmune Diseases

1983 • 158 citations

(NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction.

1981 • 157 citations

Heterogeneity of immunoregulatory T-cell subsets in systemic lupus erythematosus

1982 • 155 citations

Prostaglandin e₁ treatment of NZB/NZW F₁ hybrid MICE

1977 • 132 citations

Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content.

1982 • 126 citations

Antibodies to alpha-interferon in a patient with systemic lupus erythematosus.

1982 • 121 citations

Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus.

1981 • 120 citations

Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype.

1981 • 116 citations

Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.

1982 • 113 citations

Reaction of systemic lupus erythematosus antinative DNA antibodies with native DNA fragments from 20 to 1,200 base pairs.

1980 • 107 citations

Estrogen metabolism in systemic lupus erythematosus. Patients and family members

1982 • 103 citations

The clearance and localization of nucleic acids by New Zealand and normal mice.

1972 • 98 citations

Association of systemic lupus erythematosus and sle-like syndromes with hereditary and acquired complement deficiency states

1978 • 94 citations

Genetic studies in NZB mice. I. Spontaneous autoantibody production.

1978 • 94 citations

Kinetics and mechanisms for removal of circulating single-stranded DNA in mice.

1978 • 93 citations

A cell-mediated reaction against glomerular-bound immune complexes.

1979 • 87 citations

Genetic factors predisposing to autoimmune diseases

1982 • 82 citations

T cell abnormalities in NZB mice occur independently of autoantibody production.

1981 • 77 citations

Dietary fat affects immune response, production of antiviral factors, and immune complex disease in NZB/NZW mice.

1982 • 76 citations

Familial systemic lupus erythematosus in males

1983 • 75 citations

Studies of congenic MRL-Ipr/Ipr.xid mice.

1983 • 72 citations

Suppression of autoimmune hemolytic anemia in New Zealand (NZB) mice by syngeneic young thymocytes

1975 • 69 citations

Clearance of circulating DNA-anti-DNA immune complexes in mice.

1982 • 66 citations

Circulating anti-DNA-rheumatoid factor complexes in mice

1980 • 66 citations

Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus

1982 • 64 citations

Studies of reticuloendothelial function in the mouse with model immune complexes. II. Serum clearance, tissue uptake, and reticuloendothelial saturation in NZB/W mice.

1979 • 63 citations

In vitro correction of the interleukin 2 defect of autoimmune mice

1983 • 60 citations

Abnormalities in clonable B lymphocytes and myeloid progenitors in autoimmune NZB mice.

1979 • 59 citations

Spontaneous T-cell lymphokine production and enhanced macrophage la expression and tumoricidal acitivity in MRL-Ipr mice

1982 • 57 citations

Low-calorie diet selectively reduces expression of retroviral envelope glycoprotein gp70 in sera of NZB x NZW F1 hybrid mice.

1981 • 52 citations

Prostaglandins, immune responses, and murine lupus

1982 • 51 citations

Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance.

1982 • 50 citations

Reduction of circulating immune complexes by calorie restriction in (NZB × NZW) F1 mice

1980 • 46 citations

Age-dependent deficiency of B lymphocyte lineage precursors in NZB mice.

1982 • 45 citations

Studies of immune functions of patients with systemic lupus erythematosus

1980 • 45 citations

Transplantation of autoimmune potential. IV. Reversal of the NZB autoimmune syndrome by bone marrow transplantation.

1979 • 44 citations

Clearance of sensitized erythrocytes in NZB/NZW mice Effects of castration and sex hormone treatment

1981 • 43 citations

Accumulation of guanine-cytosine-enriched low M.W. DNA fragments in lymphocytes of patients with systemic lupus erythematosus.

1983 • 43 citations

Evidence for abnormalities in separate lymphocyte populations in NZB mice.

1980 • 42 citations

Effect of diet on survival and nephropathy of hybrid mice

1973 • 42 citations

Studies of peritoneal macrophage function in mice with systemic lupus erythematosus: Depressed phagocytosis of opsonized sheep erythrocytes in vitro

1983 • 42 citations

Effect of Thymidine Suiciding on Colony Formation in Vitro by Mouse Hematopoietic Cells

1972 • 40 citations

Defective regulation of B lymphocyte colony formation in patients with systemic lupus erythematosus.

1982 • 40 citations

The xid gene controls Ia.W39-associated immune response gene function.

1981 • 39 citations

Evidence for thymic regulation of autoimmunity in BXSB mice: acceleration of disease by neonatal thymectomy.

1983 • 37 citations

An abnormality of immune complex kinetics in murine lupus.

1981 • 37 citations

Nutritional factors and autoimmunity. III. Zinc deprivation versus restricted food intake in MRL/1 mice--the distinction between interacting dietary influences.

1982 • 35 citations

Studies of defective tolerance induction in NZB mice. Evidence for a marrow pre-T cell defect.

1982 • 32 citations

TRANSPLANTATION OF AUTOIMMUNE POTENTIAL

1975 • 31 citations

Cellular Regulation of Gamma Interferon Production: Lyt Phenotype of the Suppressor Cell

1982 • 31 citations

Interleukins and lymphocyte activation.

1982 • 31 citations

Antibodies to bovine gamma globulin (BGG) and the occurrence of a BGG-like substance in systemic lupus erythematosus sera

1972 • 29 citations

Decreased capacity to solubilize immune complexes in sera from patients with systemic lupus erythematosus

1981 • 28 citations

Hepatitis B virus surface antigen in glomerular immune complex deposits of patients with systemic lupus erythematosus

1982 • 27 citations

Family studies of B lymphocyte alloantigens in systemic lupus erythematosus.

1982 • 26 citations

NZB cells actively interfere with the establishment of tolerance to BGG in radiation chimeras.

1983 • 25 citations